The serum profile of adipokines in naïve patients with diabetes mellitus type 2 and obesity

Luis, Daniel Antonio de; Aller, R.; Izaola, Olatz; Ovalle, Hilda Fernández

doi:10.1002/jcla.20493

Cited by 3 publications

(3 citation statements)

References 24 publications

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“…However, IL-6 is also a proinflammatory factor and, when overexpressed, can lead to a variety of diseases. Significantly elevated IL-6 levels were detected in the serum of rheumatoid arthritis, diabetes, acute pancreatitis, HIV, and cancer patients [13–16]. …”

Section: Discussionmentioning

confidence: 99%

Expression Level of IL-6 Secreted by Bone Marrow Stromal Cells in Mice with Aplastic Anemia

Chen

Xie

et al. 2013

ISRN Hematology

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Parasecretion of the hematopoietic cytokines is considered as one of the mechanisms account for bone marrow hematopoiesis disorder. In this study, the level of IL-6 secreted by bone marrow stromal cells from a mouse model of aplastic anemia was analyzed. The aplastic anemia mouse model was established with cyclophosphamide in combination with chloramphenicol and 60Coγ radiation. The impairment of bone marrow hematopoiesis induced by irradiation and chemotherapeutic drugs was subsequently characterized by peripheral blood cell count, pathomorphological changes, and apoptosis rate. Furthermore, the in vitro proliferation of bone marrow stromal cells (BMSC) and the IL-6 secretion levels of BMSC were analyzed. In our model of aplastic anemia, the number of peripheral blood cells and bone marrow cells (BMC) were notably decreased, and the apoptosis rate of BMC increased. Furthermore, the proliferation of BMSC was obviously impeded while the IL-6 secretion levels of BMSC significantly increased. The findings of our study suggested that the IL-6 secretion level may be enhanced to some extent by the induction of aplastic anemia caused by irradiation and chemotherapeutic drugs and that the abnormal level of IL-6 might probably interfere with the stability of the bone marrow hematopoietic microenvironment.

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Section: Discussionmentioning

confidence: 99%

Expression Level of IL-6 Secreted by Bone Marrow Stromal Cells in Mice with Aplastic Anemia

Chen

Xie

et al. 2013

ISRN Hematology

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“…19 Much of the prior knowledge relating these mediators to clinical parameters is based on serum samples. 20–22 Our findings add to the growing pool of knowledge about adipose as a distinct tissue type and specifically to adipose in patients with advanced medical conditions such as diabetes and peripheral vascular disease necessitating major amputation.…”

Section: Discussionmentioning

confidence: 74%

Inflammatory “Adiposopathy” in Major Amputation Patients

Mauro

Nguyen

et al. 2013

Annals of Vascular Surgery

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Background Much ado has been made about obesity’s health impact, largely founded on simple patient weight and circulating adipose-derived mediator levels. Paradoxically, a “healthy obese” state exists, but substantial knowledge gaps also exist regarding human adipose-phenotype determinants. Surgical major amputation (AMP) patients are the “sickest-of-the-sick”. Conversely, elective knee-replacement (TKR) is reserved for patients who expect continued health and longevity. To delineate human adipose biology variability and clinical determinants, we studied fresh subcutaneous adipose from AMP patients, using TKR patients as controls. We hypothesized that AMP patients would display a pro-inflammatory adipokine signature, and that certain clinical conditions (diabetes, hypertension, hyperlipidemia, high BMI, uremia) would independently drive elevated adipose inflammation. Methods AMP (n=29) and TKR (n=20) adipose and clinical data were collected prospectively, and protein was isolated and analyzed for eight adipose-related mediators. Statistical analyses included Wilcoxon-rank sum, Fischer’s exact and multiple linear-regression modeling of clinical parameter predictors of mediator expression. Results IL-6, IL-8, leptin, resistin, and PAI-1 were differentially expressed (up to 200-fold) between AMP/TKR cohorts. Key clinical parameters which associated with protein levels of adipose-phenotype included age, sex, hypertension, hyperlipidemia, congestive heart failure, cerebrovascular disease, renal disease, and warfarin, statin, and insulin use, with simple BMI failing to be predictive. Conclusions AMP-patients display adiposopathy, with a pro-inflammatory adipose-phenotypic signature compared to TKR-controls. BMI fails to predict phenotype, yet other clinical conditions such as age, hyperlipidemia, and renal insufficiency do drive adipokine expression. Understanding human adipose-phenotypic determinants stands as a fundamental priority when future studies dissect the interplay between adipose biology and surgical diseases/outcomes.

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“…Its employ has autocrine, endocrine, and paracrine functions on the rest of the organs through the secretion of a wide variety of enzymes, growth factors, hormones, and cytokines, which induce the activation of specific receptors localized on cell membranes, cell proliferation, and differentiation functions. As known, cytokines that are involved in modulating physiological responses in charge of adipose tissue are called adipocytokines [9,11], so leptin, adiponectin, and tumor necrosis factor alpha (TNFα) are called some of the most important adipocytokines [12,13]. When there is a positive energy balance, the energy surplus accumulates in the subcutaneous adipose tissue.…”

Section: Adipose Tissue and The "Lipoinflammation" Conceptmentioning

confidence: 99%

Can Periodontal Disease Be Considered Linked to Obesity and Lipoinflammation? Mechanisms Involved in the Pathogenesis Occurrence

Nicolin

Costantinides

Vettori

et al. 2020

Clinic Rev Bone Miner Metab

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Obesity is a systemic disease, associated with an increased risk of cardiovascular disorders, type 2 diabetes, cancer, asthma, and osteoarthritis. Overweight and obesity have been suggested to be associated with periodontitis as published in studies and narrative summaries. Obesity and periodontal diseases are very prevalent in the world, and both can lead to severe chronic health conditions and impair people's life quality. Knowledge of how immune mechanisms and inflammatory responses are regulated is critical for understanding the pathogenesis of complex diseases, such as periodontitis. In conditions of overweight, it has been demonstrated that approximately 70-80% of individuals present an adipose tissue turnover that is both structurally and functionally causing of the systemic inflammatory reaction. The objective of this review is to explore the influence of lipoinflammation. The effects of lipoinflammation and obesity on development of periodontal disease are reported together with the exploration of the mechanisms of interaction between these two diseases.

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The serum profile of adipokines in naïve patients with diabetes mellitus type 2 and obesity

Abstract: Serum profile of adipokines is associated with different risk factors in diabetic obese patients.

Cited by 3 publications

References 24 publications

Expression Level of IL-6 Secreted by Bone Marrow Stromal Cells in Mice with Aplastic Anemia

Expression Level of IL-6 Secreted by Bone Marrow Stromal Cells in Mice with Aplastic Anemia

Inflammatory “Adiposopathy” in Major Amputation Patients

Can Periodontal Disease Be Considered Linked to Obesity and Lipoinflammation? Mechanisms Involved in the Pathogenesis Occurrence

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