The Serum YKL-40 Level is Associated with Vascular Injury and Predicts Proteinuria in Nephrotic Syndrome Patients

Koçyiğit, İsmail; Güngör, Özkan; Doğan, Ender; Karadavut, Serhat; Karakükçü, Çiğdem; Örsçelik, Özcan; Ünal, Aydın; Doğan, Ali; Sipahioğlu, Murat Hayri; Tokgöz, Bülent; Oymak, Oktay

doi:10.5551/jat.26385

Cited by 9 publications

(6 citation statements)

References 29 publications

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“…The relationship between nephrotic syndrome itself and YKL-40 protein is also very close. YKL-40 can be used as a predictor of urinary protein levels in patients with nephrotic syndrome [25]. In our results, we had found significant correlation between max-CIMT and YKL-40 ( P <0.05).…”

Section: Discussionsupporting

confidence: 55%

Plasm YKL-40 Levels Are Associated with Hypertension in Patients with Obstructive Sleep Apnea

Chen

Qin

et al. 2019

BioMed Research International

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Background. Obstructive sleep apnea (OSA) is a common disease. It can cause many serious complications. OSA may increase the risk of hypertension. However, the exact mechanism of OSA causing hypertension is not fully understood. YKL-40/chitinase-3-like protein-1 plays an important role in vascular injury, repair, and generation. We sought to explore the role of YKL-40 in endothelial dysfunction and hypertension in OSA patients. Methods. All subjects were examined by polysomnography (PSG) and the expression of YKL-40 in the plasm of the subjects was measured by luminex. Carotid intima-media thickness (CIMT) was measured by B-mode ultrasound. Results. According to the conditions of OSA and hypertension, we studied four groups of 157 subjects, including OSA group (OSA, N=77), OSA with hypertension group (OSA+HT, N=37), hypertension group (HT, N=20), and healthly group (Con, N=23). YKL-40 levels were significantly elevated in OSA, OSA+HT, and HT group compared to Con groups. We used the ROC to predict the sensitivity and specificity of YKL-40 in all OSA patients or all hyperpietic patients. For OSA patients, the AUC of YKL-40 is 0.807 (95% confidence interval 0.725–0.888; p<0.01). For hyperpietic patients, the AUC of YKL-40 is 0.656 (95% confidence interval 0.570–0.742, p=0.01). There was a significant correlation between the parameter of OSA and hypertension and YKL-40 (P<0.05) and a significant correlation between Max-CIMT and YKL-40 (P<0.05). Conclusion. Elevated circulating levels of YKL-40 are associated with hypertension in OSA patients. The specificity of YKL-40 suggests that it could be a potential biomarker for OSA and hypertension.

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Section: Discussionsupporting

confidence: 55%

Plasm YKL-40 Levels Are Associated with Hypertension in Patients with Obstructive Sleep Apnea

Chen

Qin

et al. 2019

BioMed Research International

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“… 234 In nephrotic syndrome patients the serum CHI3L1 level is associated with endothelial dysfunction and increased arterial stiffness and may be an indicator of the level of proteinuria in this patient population. 235 …”

Section: Chi3l1 In Urinary Diseasesmentioning

confidence: 99%

Chitinase-3 like-protein-1 function and its role in diseases

Zhao

et al. 2020

Sig Transduct Target Ther

326

265

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Non-enzymatic chitinase-3 like-protein-1 (CHI3L1) belongs to glycoside hydrolase family 18. It binds to chitin, heparin, and hyaluronic acid, and is regulated by extracellular matrix changes, cytokines, growth factors, drugs, and stress. CHI3L1 is synthesized and secreted by a multitude of cells including macrophages, neutrophils, synoviocytes, chondrocytes, fibroblast-like cells, smooth muscle cells, and tumor cells. It plays a major role in tissue injury, inflammation, tissue repair, and remodeling responses. CHI3L1 has been strongly associated with diseases including asthma, arthritis, sepsis, diabetes, liver fibrosis, and coronary artery disease. Moreover, following its initial identification in the culture supernatant of the MG63 osteosarcoma cell line, CHI3L1 has been shown to be overexpressed in a wealth of both human cancers and animal tumor models. To date, interleukin-13 receptor subunit alpha-2, transmembrane protein 219, galectin-3, chemo-attractant receptor-homologous 2, and CD44 have been identified as CHI3L1 receptors. CHI3L1 signaling plays a critical role in cancer cell growth, proliferation, invasion, metastasis, angiogenesis, activation of tumor-associated macrophages, and Th2 polarization of CD4+ T cells. Interestingly, CHI3L1-based targeted therapy has been increasingly applied to the treatment of tumors including glioma and colon cancer as well as rheumatoid arthritis. This review summarizes the potential roles and mechanisms of CHI3L1 in oncogenesis and disease pathogenesis, then posits investigational strategies for targeted therapies.

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“…Furthermore, it has been shown that NS is associated with endothelial dysfunction [4], and as the disease enters remission, endothelial injury improves [5]. Additionally, increased oxidative stress is associated with glomerular injury, resulting in chronic renal injury [6,7]. Researchers all over the world have focused on discovering reproducible, simple, fast, and low-cost biomarkers to evaluate endothelial dysfunction and to determine inflammatory status and oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

The Role of Monocyte to High-Density Lipoprotein Cholesterol Ratio in Predicting the Severity of Proteinuria and Renal Dysfunction in Primary Nephrotic Syndrome

Aydin¹,

Eynel²,

Oruç³

et al. 2021

Cureus

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Introduction: Monocyte to high-density lipoprotein (HDL) cholesterol ratio (MHR) has emerged as a novel marker of endothelial injury, inflammation, and oxidative stress. This study aimed to investigate the effect of MHR on primary nephrotic syndrome (NS) and its relationship with the severity of proteinuria.Methods: This study enrolled 161 patients newly diagnosed with primary NS and 100 healthy individuals. Demographic characteristics of the patients, primary NS diagnosis, basal laboratory parameters, the amount of 24-hour urinary protein excretion, and MHR were recorded. The groups were compared regarding these parameters.Results: MHR was significantly higher in patients with primary NS compared with the healthy group (12.89 ± 4.86 and 9.71 ± 2.30, respectively; p < 0.001). There was no difference between the groups in terms of age and sex. The amount of protein in the 24-hour urine in patients with a diagnosis of primary NS was 6.91 ± 3.73 g/day. The correlation analysis showed a positive correlation between MHR and the amount of proteinuria (r = 0.519, p < 0.001) and creatinine level (r = 0.167, p = 0.034). The multivariate regression analysis found that the severity of proteinuria was independently correlated to MHR (p < 0.001). According to the receiver operating characteristic curve analysis, the optimal cut-off level for MHR in NS was 10.08 (area under the curve of 0.704, sensitivity of 68%, and a specificity of 62%). Conclusion:Our study is the first to compare the severity of proteinuria and renal functions with MHR in patients with primary NS. We believe that MHR can be used as a biomarker to determine inflammation, endothelial injury, and the level of oxidative stress, and may be useful to predict prognosis in patients with primary NS.

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The Serum YKL-40 Level is Associated with Vascular Injury and Predicts Proteinuria in Nephrotic Syndrome Patients

Cited by 9 publications

References 29 publications

Plasm YKL-40 Levels Are Associated with Hypertension in Patients with Obstructive Sleep Apnea

Plasm YKL-40 Levels Are Associated with Hypertension in Patients with Obstructive Sleep Apnea

Chitinase-3 like-protein-1 function and its role in diseases

The Role of Monocyte to High-Density Lipoprotein Cholesterol Ratio in Predicting the Severity of Proteinuria and Renal Dysfunction in Primary Nephrotic Syndrome

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