The severity of COVID‐19 among pregnant women and the risk of adverse maternal outcomes

Samadi, Parisa; Alipour, Zahra; Ghaedrahmati, Maryam; Ahangari, Roghaye

doi:10.1002/ijgo.13700

Cited by 30 publications

(41 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similarly, high rates of cesarean delivery, around 50% and above, have been described in both high-income countries and LMICs in many large studies of women admitted with SAR-CoV-2 infection. 9,[12][13][14] Of concern is the high mortality rate in the present cohort, in particular among those admitted primarily due to clinical SARS-CoV-2 illness. Mortality rates in the present cohort are higher than those identified in the UKOSS study, 12 which was based on the same protocol and focused on hospitalized women but predominantly in a high-income setting.…”

Section: Discussionmentioning

confidence: 90%

Maternal characteristics and pregnancy outcomes of hospitalized pregnant women with SARS‐CoV‐2 infection in South Africa: An International Network of Obstetric Survey Systems‐based cohort study

Budhram

Vannevel

Botha

et al. 2021

Intl J Gynecology & Obste

View full text Add to dashboard Cite

Objective: To describe risk factors and outcomes of pregnant women infected with SARS-CoV-2 admitted to South African healthcare facilities. Methods:A population-based cohort study was conducted utilizing an amended International Obstetric Surveillance System protocol. Data on pregnant women with SARS-CoV-2 infection, hospitalized between April 14, 2020, and November 24, 2020, were analyzed.Results: A total of 36 hospitals submitted data on 673 infected hospitalized pregnant women; 217 (32.2%) were admitted for COVID-19 illness and 456 for other indications. There were 39 deaths with a case fatality rate of 6.3%: 32 (14.7%) deaths occurred in women admitted for COVID-19 illness compared to 7 (1.8%) in women admitted for other indications. Of the women, 106 (15.9%) required critical care.Maternal tuberculosis, but not HIV co-infection or other co-morbidities, was associated with admission for COVID-19 illness. Rates of cesarean delivery did not differ significantly between women admitted for COVID-19 and those admitted for other indications. There were 179 (35.4%) preterm births, 25 (4.7%) stillbirths, 12 (2.3%) neonatal deaths, and 162 (30.8%) neonatal admissions. Neonatal outcomes did not differ significantly from those of infected women admitted for other indications. Conclusion:The maternal mortality rate was high among women admitted with SARS-CoV-2 infection and higher in women admitted primarily for COVID-19 illness with tuberculosis being the only co-morbidity associated with admission.

show abstract

Section: Discussionmentioning

confidence: 90%

Maternal characteristics and pregnancy outcomes of hospitalized pregnant women with SARS‐CoV‐2 infection in South Africa: An International Network of Obstetric Survey Systems‐based cohort study

Budhram

Vannevel

Botha

et al. 2021

Intl J Gynecology & Obste

View full text Add to dashboard Cite

show abstract

“…Moreover, our study reported a significant association between parity (being multigravida) and developing adverse obstetric outcomes of COVID-19, which confirms Samadi et al . observations 18 . Nevertheless, results from a previous systematic analysis contradicted this finding 36 .…”

Section: Discussionmentioning

confidence: 90%

“…Overall, incidence rates of the abovementioned outcomes were significantly high among patients with severe clinical manifestation compared to those with uncomplicated course of the disease. Similarly, several studies indicated an increased risk of adverse obstetric and neonatal outcomes among pregnant women with severe COVID-19 17 , 18 .…”

Section: Discussionmentioning

confidence: 97%

Investigating the association between severity of COVID-19 infection during pregnancy and neonatal outcomes

Dileep¹,

ZainAlAbdin

AbuRuz

2022

Sci Rep

View full text Add to dashboard Cite

Pregnant women with COVID-19 require special attention and care, since the infection does not only affect the mother, but also her neonate and adversely affects pregnancy outcomes. The main goal of this retrospective cohort study is to investigate association between the maternal COVID-19 severity and risk of developing adverse neonatal outcomes. Patients were stratified into asymptomatic/mild and moderate to severe COVID-19. The following neonatal outcomes were assessed: gestational age at the time of delivery, birth weight, neonatal infection, neonatal intensive care unit (NICU) admission. The average age of patients was 28.5 ± 1.4 years old and majority were multigravida (74.0%, n = 148). Of total 200 pregnant women with COVID-19, 26.5% (n = 53) had moderate/severe disease and presented with higher incidence of preterm delivery and low birth weight (88.7%, n = 47; p < 0.001). In addition, more than half of the newborns delivered by mothers with severe disease were infected by SARS-COV-2 (58.5%, n = 31) and majority were admitted to the NICU (95.0%, n = 52). Based on the multivariate logistic regression analysis, pregnant women with moderate to severe COVID-19 were at much higher risk of preterm delivery, lower birth weight, neonatal infection, as well as neonatal ICU admission (p < 0.001). In addition, multigravida women were at higher risk for preterm delivery and lower birth weight (p = 0.017 and p = 0.02; respectively). Appropriate protective measures and early detection of suspected COVID-19 should be addressed for more favorable obstetric outcomes.

show abstract

“…Of the infected pregnant women presenting with COVID-19 symptoms, about 80–85% experienced mild-to-moderate illness such as fever, sore throat, cough, loss of taste and smell, headache, fatigue, and shortness of breath ( 8 , 10 – 13 ). Approximately 15–20% of infected pregnant women have severe or critical conditions requiring hospitalization, mechanical ventilation, and intensive medical care ( 1 , 8 , 10 – 13 ).…”

Section: Introductionmentioning

confidence: 99%

A Micro-Level Analysis of Physiological Responses to COVID-19: Continuous Monitoring of Pregnant Women in California

Jimah

Kehoe

Borg

et al. 2022

Front. Public Health

View full text Add to dashboard Cite

Continuous monitoring of perinatal women in a descriptive case study allowed us the opportunity to examine the time during which the COVID-19 infection led to physiological changes in two low-income pregnant women. An important component of this study was the use of a wearable sensor device, the Oura ring, to monitor and record vital physiological parameters during sleep. Two women in their second and third trimesters, respectively, were selected based on a positive COVID-19 diagnosis. Both women were tested using the polymerase chain reaction method to confirm the presence of the virus during which time we were able to collect these physiological data. In both cases, we observed 3–6 days of peak physiological changes in resting heart rate (HR), heart rate variability (HRV), and respiratory rate (RR), as well as sleep surrounding the onset of COVID-19 symptoms. The pregnant woman in her third trimester showed a significant increase in resting HR (p = 0.006) and RR (p = 0.048), and a significant decrease in HRV (p = 0.027) and deep sleep duration (p = 0.029). She reported experiencing moderate COVID-19 symptoms and did not require hospitalization. At 38 weeks of gestation, she had a normal delivery and gave birth to a healthy infant. The participant in her second trimester showed similar physiological changes during the 3-day peak period. Importantly, these changes appeared to return to the pre-peak levels. Common symptoms reported by both cases included loss of smell and nasal congestion, with one losing her sense of taste. Results suggest the potential to use the changes in cardiorespiratory responses and sleep for real-time monitoring of health and well-being during pregnancy.

show abstract

The severity of COVID‐19 among pregnant women and the risk of adverse maternal outcomes

Cited by 30 publications

References 17 publications

Maternal characteristics and pregnancy outcomes of hospitalized pregnant women with SARS‐CoV‐2 infection in South Africa: An International Network of Obstetric Survey Systems‐based cohort study

Maternal characteristics and pregnancy outcomes of hospitalized pregnant women with SARS‐CoV‐2 infection in South Africa: An International Network of Obstetric Survey Systems‐based cohort study

Investigating the association between severity of COVID-19 infection during pregnancy and neonatal outcomes

A Micro-Level Analysis of Physiological Responses to COVID-19: Continuous Monitoring of Pregnant Women in California

Contact Info

Product

Resources

About