The Seveso accident: A look at 40 years of health research and beyond

Eskenazi, Brenda; Warner, Malcolm; Brambilla, Paolo; Signorini, Stefano; Ames, Jennifer; Mocarelli, Paolo

doi:10.1016/j.envint.2018.08.051

Cited by 114 publications

(76 citation statements)

References 86 publications

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“…Previously, 24 µg/kg BW of TCDF has been validated with allometric calculations to represent a dose of 3000 ng/kg in humans, in mice [9]. Moreover, 3000 ng/kg represented the exposure level of the Seveso, Italy 2,4,5-trichlorophenol reactor accident, where human exposures were reported to be between 2.5 and 56,000 ng/kg in blood [22]. Liquid chromatography coupled with mass spectrometry (LCMS), endotoxin assays, 16S rRNA gene amplicon sequencing, pathway enrichment analysis, and bacterial metatranscriptomics were used to investigate and validate TCDF modulation of the intestinal microbiome composition and function.…”

Section: Introductionmentioning

confidence: 99%

Metatranscriptomic Analysis of the Mouse Gut Microbiome Response to the Persistent Organic Pollutant 2,3,7,8-Tetrachlorodibenzofuran

et al. 2019

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Persistent organic pollutants (POPs) are important environmental chemicals and continued study of their mechanism of action remains a high priority.POPs, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 2,3,7,8-tetrachlorodibenzofuran (TCDF), and polychlorinated biphenyls (PCBs), are widespread environmental contaminants that are agonists for the aryl hydrocarbon receptor (AHR). Activation of the AHR modulates the gut microbiome community structure and function, host immunity, and the host metabolome. In the current study, male C57BL6/J mice were exposed, via the diet, to 5 µg/kg body weight (BW) TCDF or 24 µg/kg BW of TCDF every day for 5 days. The functional and structural changes imparted by TCDF exposure to the gut microbiome and host metabolome were explored via 16S rRNA gene amplicon sequencing, metabolomics, and bacterial metatranscriptomics. Significant changes included increases in lipopolysaccharide (LPS) biosynthesis gene expression after exposure to 24 µg/kg BW of TCDF. Increases in LPS biosynthesis were confirmed with metabolomics and LPS assays using serum obtained from TCDF-treated mice. Significant increases in gene expression within aspartate and glutamate metabolism were noted after exposure to 24 µg/kg BW of TCDF. Together, these results suggest that after exposure to 24 µg/kg BW of TCDF, the gut microbiome increases the production of LPS and glutamate to promote localized gut inflammation, potentially using glutamate as a stress response.

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Section: Introductionmentioning

confidence: 99%

Metatranscriptomic Analysis of the Mouse Gut Microbiome Response to the Persistent Organic Pollutant 2,3,7,8-Tetrachlorodibenzofuran

et al. 2019

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“…Although naturally occurring in trace amounts, DLCs are primarily of anthropogenic origin and are now widely distributed in environments worldwide as a result of improper disposal and environmental transport. The health consequences of DLC exposure can be severe, including cancer, developmental defects and cardiovascular disease, and can have devastating effects in wildlife (Cook et al, 2003) and humans (Eskenazi et al, 2018). These devastating risks make DLCs among the most widely studied toxicants.…”

Section: Natural and Synthetic Toxicants: Arsenic And Dioxin As Exampmentioning

confidence: 99%

Casting a wide net: use of diverse model organisms to advance toxicology

Hahn

Sadler

2020

Disease Models &Amp; Mechanisms

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Toxicologythe study of how chemicals interact with biological systemshas clear relevance to human health and disease. Persistent exposure to natural and synthetic chemicals is an unavoidable part of living on our planet; yet, we understand very little about the effects of exposure to the vast majority of chemicals. While epidemiological studies can provide strong statistical inference linking chemical exposure to disease, research in model systems is essential to elucidate the mechanisms of action and to predict outcomes. Most research in toxicology utilizes a handful of mammalian models that represent a few distinct branches of the evolutionary tree. This narrow focus constrains the understanding of chemical-induced disease processes and systems that have evolved in response to exposures. We advocate for casting a wider net in environmental toxicology research to utilize diverse model systems, including zebrafish, and perform more mechanistic studies of cellular responses to chemical exposures to shift the perception of toxicology as an applied science to that of a basic science. This more-inclusive perspective will enrich the field and should remain central to research on chemical-induced disease.

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“…Эти вещества являются причиной таких патологий, как болезнь Дауна, волчья пасть, заячья губа, нарушение развития конечностей. Среди отдаленных последствий действия ДиФ наблюдаются онкологические заболевания [9,15]. Время полу выведения из организма диоксинов составляет от 1,5 до 16 лет в зависимости от токсичности вещества.…”

Section: диоксины и фураны: характеристика и воздействие на окружающуunclassified

Dioxins and furans in zinc-containing metallurgical dust: behavior and formation processes

Simonyan

Демидова

2019

Izv. vysš. učebn. zaved., Čern. metall.

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The use of galvanized scrap as a charge material for electric steel-smelting production leads to the formation of metallurgical dust suitable for the extraction of non-ferrous metals. The issues related to the behavior of chlorine and its compounds in zinc and lead containing EAF-dust is not sufficiently studied. Current research exhibits the danger of chlorine and its compounds in charge and, consequently, in emissions of EAF. Chlorine and its compounds are considered to be the main components associated with the formation of highly toxic organic substances – dioxins and furans (D&F). D&F enter the environment not only in gaseous form, but also in the form of compounds adsorbed on the surface of dust particles. According to various data, D&F concentration is 5-500 ng / kg of dust and depends on the technological parameters of melting. Analysis of the formation processes of D&F in EAF and their behavior in the captured dust is given. It was found that at the studied chlorine content of 1.3% in EAF-dust from the charge materials, 99.9% of chlorine form relatively safe compounds, mainly chlorides, and a small amount goes to the formation of D&F. The amount of D&F adsorbed on the surface of captured dust particles was 474 ng / kg of dust. As strong toxicants, D&F increase the hazard category of dust from the 4th to the 3rd and above that must be considered at dust usage. In addition, the transport of D&F in the environment is due to solid particles that absorb poisons on their surface. Therefore, EAF dust, with D&F adsorbed on its surface, can provoke their entry into organisms. The ways of reducing D&F emission in the production of EAF-steel and the resource-saving and environmentally safe technologies of dust processing are considered. In particular, the possibility of using lime milk for the off-gases irrigation in the EAF gas flue was analyzed and it was shown that it allows to reduce the D&F content to acceptable limits. The efficiency of the proposed activities was evaluated.

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The Seveso accident: A look at 40 years of health research and beyond

Cited by 114 publications

References 86 publications

Metatranscriptomic Analysis of the Mouse Gut Microbiome Response to the Persistent Organic Pollutant 2,3,7,8-Tetrachlorodibenzofuran

Metatranscriptomic Analysis of the Mouse Gut Microbiome Response to the Persistent Organic Pollutant 2,3,7,8-Tetrachlorodibenzofuran

Casting a wide net: use of diverse model organisms to advance toxicology

Dioxins and furans in zinc-containing metallurgical dust: behavior and formation processes

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The Seveso accident: A look at 40 years of health research and beyond

Cited by 114 publications

References 86 publications

Metatranscriptomic Analysis of the Mouse Gut Microbiome Response to the Persistent Organic Pollutant 2,3,7,8-Tetrachlorodibenzofuran

Metatranscriptomic Analysis of the Mouse Gut Microbiome Response to the Persistent Organic Pollutant 2,3,7,8-Tetrachlorodibenzofuran

Casting a wide net: use of diverse model organisms to advance toxicology

Dioxins and furans in zinc-containing metallurgical dust: behavior and formation processes

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The Seveso accident: A look at 40 years of health research and beyond