The Sex-Specific Detrimental Effect of Diabetes and Gender-Related Factors on Pre-admission Medication Adherence Among Patients Hospitalized for Ischemic Heart Disease: Insights From EVA Study

Raparelli, Valeria; Proietti, Marco; Romiti, Giulio Francesco; Lenzi, Andrea; Basili, Stefania

doi:10.3389/fendo.2019.00107

Cited by 7 publications

(7 citation statements)

References 45 publications

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“…Biological sex and gender-related (i.e., psycho-socio-cultural) factors play an important role as health determinants. Despite their importance, however, both aspects are generally overlooked and underreported [11][12][13][14][15][16]. Specifically, gender represents a complex construct, which includes the behavioral, cultural, environmental, and social characteristics of the individual [11,17].…”

Section: Introductionmentioning

confidence: 99%

Gender-Related Determinants of Adherence to the Mediterranean Diet in Adults with Ischemic Heart Disease

et al. 2020

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Background: The reasons behind low adherence to the Mediterranean diet (Med-diet) are still not entirely known. We aimed to evaluate the effect of biological (i.e., sex-related) and psycho-socio-cultural (i.e., gender-related) factors on Med-diet adherence. Methods: Baseline Med-diet adherence was measured using a self-administered questionnaire among adults with ischemic heart disease (IHD) from the EVA (Endocrine Vascular Disease Approach) study. A multivariable analysis was performed to estimate the effect of sex- and gender-related factors (i.e., identity, roles, relations, and institutionalized gender) on low adherence. Results: Among 366 participants (66 ± 11 years, 31% women), 81 (22%) adults with low adherence demonstrated higher rates of diabetes, no smoking habit, lower male BSRI (Bem Sex Role Inventory) (median (IQR) 4.8 (4.1 to 5.5) vs. 5.1 (4.5 to 5.6) and p = 0.048), and higher Perceived Stress Scale 10 items (PSS-10) (median (IQR) 19 (11 to 23) vs. 15 (11 to 20) and p = 0.07) scores than those with medium-high adherence. In the multivariable analysis, only active smoking (odds ratio, OR = 2.10, 95% confidence interval, CI 1.14 to 3.85 and p = 0.017), PPS-10 (OR = 1.04, 95% CI 1.00 to 1.08, and p = 0.038) and male BSRI scores (OR = 0.70, 95% CI 0.52 to 0.95, and p = 0.021) were independently associated with low adherence. Conclusions: Male personality traits and perceived stress (i.e., gender identity) were associated with low Med-diet adherence regardless of the sex, age, and comorbidities. Therefore, gender-sensitive interventions should be explored to improve adherence in IHD.

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Section: Introductionmentioning

confidence: 99%

Gender-Related Determinants of Adherence to the Mediterranean Diet in Adults with Ischemic Heart Disease

et al. 2020

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“…In the future, more studies are required to investigate the underlying physiological changes in women with AMI. In addition, the literature indicates that women have poorer medication adherence after MI than men, 23 and similar findings have been reported in the medical treatment of hyperlipidemia 24 and diabetes mellitus 25 . On the assessment and treatment of cardiovascular risk factors, compared with men, women, especially younger women, reported receiving less according to the guideline‐recommend management 24,26 .…”

Section: Discussionmentioning

confidence: 58%

“…In addition, the literature indicates that women have poorer medication adherence after MI than men, 23 and similar findings have been reported in the medical treatment of hyperlipidemia 24 and diabetes mellitus. 25 On the assessment and treatment of cardiovascular risk factors, compared with men, women, especially younger women, reported receiving less according to the guideline-recommend management. 24,26 Therefore, the underestimation and even improper treatment of women's CV risk might be another underlying reason for the poor long-term prognosis of women with AMI.…”

Section: Characteristicsmentioning

confidence: 99%

Sex differences in long‐term cardiovascular outcomes among patients with acute myocardial infarction: A population‐based retrospective cohort study

Chang

Lin

Chen

et al. 2021

Int. J. Clin. Pract.

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Background: Whether a sex difference exists in long-term cardiovascular (CV) outcomes after acute myocardial infarction (AMI) is worth exploration. This study is sought to investigate the relationships among sex, age, and the long-term prognosis after AMI. Methods: This population-based retrospective cohort study used Taiwan's NationalHealth Insurance Research Database to investigate the sex differences in in-hospital and long-term CV outcomes in patients with AMI. We enrolled patients who were first diagnosed with AMI from January 1, 2000 to December 31, 2013. The outcomes of interest included all-cause mortality, CV death, non-fatal stroke, non-fatal heart failure, and AMI recurrence during hospitalization and 5-year follow up. The CV outcomes were also analyzed by age stratification.Results: Overall, 201 921 patients with AMI were analyzed; 68.72% were men and 31.28% were women, with mean ages of 65.34 ± 14.12 and 73.05 ± 12.22 years, respectively. Major adverse cardiac events during hospitalization and up to 5 years were consistently greater in women than in men. Multivariable regression analysis revealed no sex difference existed in long-term all-cause and CV mortality. Men of all age groups consistently showed higher risk of both short-and long-term recurrence of AMI. Nonetheless, the female sex still independently predicted increased risk of non-fatal stroke and heart failure from hospitalization until 3-year follow up. Conclusion:Women with AMI had poorer short-term and long-term outcomes. The sex differences in long-term all-cause and CV death disappear after multivariate analysis. Nonetheless, female AMI patients independently predicted higher risk of stroke and heart failure from hospitalization until a 3-year follow-up. To better understand the pathophysiology of female patients with AMI and develop more effective management, more studies in this field are necessary in the future. | INTRODUC TI ONAcute myocardial infarction (AMI) is one of the most dangerous cardiovascular (CV) diseases, and its long-term prognosis is usually poor.In recent years, with the development of research on and treatment of atherosclerotic CV disease, the death rate of myocardial infarction (MI) at the acute phase has decreased significantly. 1 Because women have traditionally been thought to have less CV disease compared with men, whether a sex difference exists in the prognosis of patients with MI in the acute and long-term stages has always How to cite this article: Chang S-S, Lin S-Y, Lai J-N, et al. Sex differences in long-term cardiovascular outcomes among patients with acute myocardial infarction: A populationbased retrospective cohort study. Int J Clin Pract.

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“…In another study, the results showed that there were no differences in sex between medium-high-compliant and low-compliant subjects. The sex-stratified analysis demonstrated that low-compliant men were more likely to be employed ( 30 ). In another study, no significant sex differences were observed ( 31 , 32 ).…”

Section: Discussionmentioning

confidence: 99%

Timely referral to health centers for the prevention of cardiovascular diseases: IraPEN national program

Hadavandsiri,

Khalili,

Mahdavi

et al. 2023

Front. Public Health

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IntroductionThe IraPEN program is an adapted version of the WHO-PEN program designed to prevent four major non-communicable diseases in Iran. This study aimed to determine the rate of compliance and related factors among individuals participating in the IraPEN program for the prevention of cardiovascular disease.MethodIn this study, compliance was defined as timely referral to the health center as scheduled, and the researchers approached four pilot sites of IraPEN from March 2016 to March 2018. Sex-stratified logistic regressions were applied to investigate factors related to compliance. However, it is important to note that in this study, compliance was defined as compliance to revisit, not compliance to taking prescribed medications or behavioral lifestyle changes.ResultsThe total compliance rate, including timely compliance and early and late compliance, was 16.5% in men and 23.3% in women. The study found that cardiovascular risk factors such as diabetes, hypertension, hypercholesterolemia, and being underweight were associated with lower compliance. The higher calculated risk of CVD was associated with higher compliance, but after adjusting for cardiovascular risk factors, high-risk individuals showed lower compliance. There was negligible interaction between sex and other factors for compliance.ConclusionThe compliance rate with scheduled programs for cardiovascular preventive strategies was very low, and high-risk individuals were less compliant, regardless of their high level of risk factors. The study recommends further training to increase awareness and knowledge regarding the IraPEN program and the prevention of non-communicable diseases among high-risk populations.

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The Sex-Specific Detrimental Effect of Diabetes and Gender-Related Factors on Pre-admission Medication Adherence Among Patients Hospitalized for Ischemic Heart Disease: Insights From EVA Study

Cited by 7 publications

References 45 publications

Gender-Related Determinants of Adherence to the Mediterranean Diet in Adults with Ischemic Heart Disease

Gender-Related Determinants of Adherence to the Mediterranean Diet in Adults with Ischemic Heart Disease

Sex differences in long‐term cardiovascular outcomes among patients with acute myocardial infarction: A population‐based retrospective cohort study

Timely referral to health centers for the prevention of cardiovascular diseases: IraPEN national program

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