In order to investigate the coupling coordination relationship between urban economic upgrading and labor employment, a computational model based on GTAP is proposed in the research. The main content is that based on the basic principle of GTAP model, the sum calculation of regions and departments is selected, the time cost is introduced into the GTAP model, the relevant research on the employment of labor population is conducted, and the results such as the impact of labor quality improvement on China's industry is finally obtained.The experimental results show that, based on the calculation of GTAP model, the decrease of unskilled labor force and the increase of skilled labor force will lead to the decrease of the output of unskilled intensive industry by 0.80%, the increase of the output of skilled labor intensive industry by 0.24%, and the increase of the output of capital intensive industry and service industry by 0.29% and 0.20% respectively. But the output of agriculture, food