The Short-Chain Fatty Acid Propionate Inhibits Adipogenic Differentiation of Human Chorion-Derived Mesenchymal Stem Cells Through the Free Fatty Acid Receptor 2

Iván, Judit; Major, E; Sipos, Áron; Kovács, Katalin; Horváth, Dorottya; Tamás, István; Bay, Péter; Dombrádi, Viktor; Lontay, Beáta

doi:10.1089/scd.2017.0035

Cited by 48 publications

(40 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, oral administration of SCFAs (acetic acid, propionic acid, and butyric acid) decreases the concentration of triglyceride (TG) and could attenuate the fat deposition of pigs [76]. In addition, evidence in mouse and human also demonstrates that SCFAs modulate adipogenesis and attenuate lipolysis [77][78][79][80][81][82][83]. Therefore, SCFAs regulate energy metabolism via activating their receptors on adipocytes, which may produce adipokines such as leptin to participate in the development of CVDs.…”

Section: Scfas and Adipose Tissuementioning

confidence: 99%

Short-chain fatty acid, acylation and cardiovascular diseases

2020

View full text Add to dashboard Cite

Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. Metabolic dysfunction is a fundamental core mechanism underlying CVDs. Previous studies generally focused on the roles of long-chain fatty acids (LCFAs) in CVDs. However, a growing body of study has implied that short-chain fatty acids (SCFAs: namely propionate, malonate, butyrate, 2-hydroxyisobutyrate (2-HIBA), β-hydroxybutyrate, crotonate, succinate, and glutarate) and their cognate acylations (propionylation, malonylation, butyrylation, 2-hydroxyisobutyrylation, β-hydroxybutyrylation, crotonylation, succinylation, and glutarylation) participate in CVDs. Here, we attempt to provide an overview landscape of the metabolic pattern of SCFAs in CVDs. Especially, we would focus on the SCFAs and newly identified acylations and their roles in CVDs, including atherosclerosis, hypertension, and heart failure. Clinical Science (2020) 134 657-676 https://doi.org/10.1042/CS20200128 cofactors in certain protein acylations, such as propionylation [14], malonylation [15], butyrylation [14], 2-hydroxyisobutyrylation [16], β-hydroxybutyrylation [17], crotonylation [18], succinylation [19], and glutarylation [20]. These discoveries give us a deeper understanding of PTM. Among PTMs, protein acetylation is the earliest discovered and most studied. Similar to protein acetylation, various studies have shown that these newly discovered PTMs are also involved in physiological and pathophysiological processes, including cardiovascular homeostasis.Here in this review, we will summarize SCFAs, protein acylations, and their emerging roles in CVDs, including atherosclerosis, hypertension, and heart failure. The metabolic pattern and FAs in CVDsThe heart is an 'omnivore' , using FAs, glucose, lactate, ketone bodies, and amino acids as metabolic substrates [5,6]. The substrates utilized by the embryonic heart are significantly different from those used by the adult heart. The embryonic heart depends primarily on glycolysis as well as lactate oxidation to produce energy [21]. The newborn and adult heart shift toward the remarkable utilization of FAs to meet cardiac energy demand [5,9]. In failing hearts, a decrease in FA oxidation and an increase in glycolysis are critically involved in cardiac dysfunction [22]. As thus, the metabolic pattern is essential for maintaining cardiac and vascular functions.Diabetes, hypertension, and obesity contribute to heart failure syndrome. Accumulating evidence suggests that hypertension, ischemic hearts, and heart failure induce a shift in substrate toward the remarkable utilization of glucose to generate energy. Despite this shift, the FA oxidation remains to make much energy for the diseased heart [23]. Since FAs are the predominant substrates for cardiomyocytes, alterations in FA metabolism have been implicated as causal in cardiac diseases. FAs within cells and in the circulation are critically involved in cardiometabolic diseases. CVDs are closely associated with lifestyle and metabolic status, which affect circul...

show abstract

Section: Scfas and Adipose Tissuementioning

confidence: 99%

Short-chain fatty acid, acylation and cardiovascular diseases

2020

View full text Add to dashboard Cite

show abstract

“…The fermentation of nondigestible carbohydrates is beneficial for the host due to the generation of short-chain fatty acids (SCFAs), such as acetate, butyrate, formate, lactate, and propionate. SCFAs are novel potential targets for the management of obesity, metabolic disorders, and lipomas, due to their ability to influence adipocyte differentiation [60]. SCFAs have known anti-inflammatory, antiproliferative, and antineoplastic effects.…”

Section: Bacterial Metabolites In Carcinogenesismentioning

confidence: 99%

The Microbiome as a Component of the Tumor Microenvironment

Kovàcs

Mikó

Ujlaki

et al. 2020

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

show abstract

“…14,15 As a result, more damaged mitochondria results along with an accumulation of ROS and imbalance between glycolysis and OXPHOS, eventually erroneous differentiation and proliferation of stem cells and in turn depletion of stem cell. 16 Evidence in support of this notion comes from old HSCs ex- 19 In line with butyrate, another SFCA propionate also demonstrates the inhibitory effect on the differentiation capacity of human chorion-derived mesenchymal stem cells (sMSCs) 20 . Reducing the differentiation capacity of stem cells is a requisite hallmark of ageing.…”

Section: Host Microbiome and Metabolic Changes In Stem Cell Ageingmentioning

confidence: 96%

Save your gut save your age: The role of the microbiome in stem cell ageing

Tan

Wei

Chen

et al. 2019

J Cellular Molecular Medi

View full text Add to dashboard Cite

The tremendous importance of microbiota in microbial homoeostasis, alterations in metabolism and both innate and adaptive immune systems has been well established. A growing body of evidence support that dysbiosis or compositional changes in gut microbiota is linked to the ageing of stem cells in terms of dysregulations of metabolism, aberrant activation of the immune system as well as promoting epigenetic instability of stem cell. In this concise review, we elucidate recent emerging topics on microbiotic alterations and underlying mechanisms in stem cell ageing.

show abstract

The Short-Chain Fatty Acid Propionate Inhibits Adipogenic Differentiation of Human Chorion-Derived Mesenchymal Stem Cells Through the Free Fatty Acid Receptor 2

Cited by 48 publications

References 43 publications

Short-chain fatty acid, acylation and cardiovascular diseases

Short-chain fatty acid, acylation and cardiovascular diseases

The Microbiome as a Component of the Tumor Microenvironment

Save your gut save your age: The role of the microbiome in stem cell ageing

Contact Info

Product

Resources

About