The short synacthen test: Variations in methodology and protocols in KSA

Butt, Muhammad Imran; Alzuhayri, Nouf; Riazuddin, Muhammad; Bakhsh, Abdulmohsen Mohammed Khalid

doi:10.1016/j.jtumed.2022.01.010

Cited by 1 publication

(1 citation statement)

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“…The assays of baseline cortisol were the most frequent measurements (90%), followed by adrenocorticotropic hormone (ACTH) measurements (78%) whereas only 75% of clinicians assessed the hormones at 30 or 60 minutes, respectively; 93% of them considered the level of plasma cortisol of 550 nmol/L as the normal cutoff. 35 The other survey (among 221 practitioners in pediatric endocrinology) showed that 85% of them used high-dose SST for the diagnosis of AD, but with heterogeneous interpretations of the assays. 36 …”

Section: Resultsmentioning

confidence: 99%

Addison’s Disease: Diagnosis and Management Strategies

Cârșote¹,

Nistor²

2023

IJGM

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We aim to overview Addison’s disease (AD) with regard to current diagnosis and management. This is a narrative review of full-length articles published in English between January 2022 and December 2022 (including online ahead of print versions) in PubMed-indexed journals. We included original studies in living humans regardless of the level of statistical significance starting from the key search terms “Addison’s disease” or “primary adrenal insufficiency” in title or abstract. We excluded articles with secondary adrenal insufficiency. Briefly, 199 and 355 papers, respectively were identified; we manually checked each of them, excluded the duplicates, and then selected 129 based on their clinical relevance in order to address our 1-year analysis. We organized the data in different subsections covering all published aspects on the subject of AD. To our knowledge, this is the largest AD retrospective from 2022 on published data. A massive role of genetic diagnosis especially in pediatric cases is highlighted; the importance of both pediatric and adult awareness remains since unusual presentations continue to be described. COVID-19 infection is a strong player amid this third year of pandemic although we still not do have large cohorts in this particular matter as seen, for instance, in thyroid anomalies. In our opinion, the most important topic for research is immune checkpoint inhibitors, which cause a large panel of endocrine side effects, AD being one of them.

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Section: Resultsmentioning

confidence: 99%