The short-term effect of fatty acids on glucagon secretion is influenced by their chain length, spatial configuration, and degree of unsaturation: studies in vitro

Hong, Jing; Abudula, Reziwanggu; Chen, Jianguo; Jeppesen, Per Bendix; Dyrskog, Stig; Xiao, Jianzhong; Colombo, Michele; Hermansen, Kjeld

doi:10.1016/j.metabol.2005.04.022

Cited by 37 publications

(36 citation statements)

References 47 publications

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“…Bollheimer et al demonstrated that both acute palmitate and oleate stimulation resulted in increased glucagon secretion from isolated rat islets [7], and the same result was seen in mouse islets treated with palmitate [9]. A recent thorough investigation revealed that glucagon secretion from isolated mouse islets was enhanced by a spectrum of medium to long chain FFAs [8]. However, the mechanism behind the glucagonotropic actions of FFAs has still not been elucidated.…”

Section: Discussionmentioning

confidence: 99%

“…Although FFAs are vital components involved in the regulation of many metabolic processes, the activation of GPR40 seems to be of great importance for acute insulin secretion. FFAs have been shown to acutely stimulate glucagon secretion [7][8][9],but the mechanisms behind this are not fully understood. In the present work we studied the role of GPR40 in FFA induced glucagon secretion.…”

Section: Introductionmentioning

confidence: 99%

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GPR40 is expressed in glucagon producing cells and affects glucagon secretion

Flodgren

Olde

Meidute-Abaraviciene

et al. 2007

Biochemical and Biophysical Research Communications

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

GPR40 is expressed in glucagon producing cells and affects glucagon secretion

Flodgren

Olde

Meidute-Abaraviciene

et al. 2007

Biochemical and Biophysical Research Communications

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“…While initial studies suggested an inhibitory effect on glucagon secretion (Andrews et al 1975), more recent investigations have indicated that short-term exposure to fatty acids stimulates the release of this hormone (Bollheimer et al 2004, Olofsson et al 2004, Hong et al 2005. The short-term stimulatory action depends on the chain length, spatial configuration and degree of saturation of the fatty acid (Hong et al 2005). The action of palmitate has been studied in mice at the cell level.…”

Section: Regulation Of Glucagon Secretion By Fatty Acids and Amino Acidsmentioning

confidence: 99%

Physiology of the pancreatic α-cell and glucagon secretion: role in glucose homeostasis and diabetes

Quesada¹,

Tudurí²,

Ripoll³

et al. 2008

Journal of Endocrinology

337

330

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The secretion of glucagon by pancreatic a-cells plays a critical role in the regulation of glycaemia. This hormone counteracts hypoglycaemia and opposes insulin actions by stimulating hepatic glucose synthesis and mobilization, thereby increasing blood glucose concentrations. During the last decade, knowledge of a-cell physiology has greatly improved, especially concerning molecular and cellular mechanisms. In this review, we have addressed recent findings on a-cell physiology and the regulation of ion channels, electrical activity, calcium signals and glucagon release. Our focus in this review has been the multiple control levels that modulate glucagon secretion from glucose and nutrients to paracrine and neural inputs. Additionally, we have described the glucagon actions on glycaemia and energy metabolism, and discussed their involvement in the pathophysiology of diabetes. Finally, some of the present approaches for diabetes therapy related to a-cell function are also discussed in this review. A better understanding of the a-cell physiology is necessary for an integral comprehension of the regulation of glucose homeostasis and the development of diabetes.

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“…On the other hand, it has been reported that FFAs stimulated glucagon secretion, leading to a possible a-cells dysfunction with an increased glucagon secretion in type 2 diabetes (Bollheimer et al 2004, Hong et al 2005, Fujiwara et al 2007. It is known now that FFAs not only are the fuel for cell metabolism but also function as extracellular messengers to activate intracellular signal pathways through membrane receptors such as GPR40 (Salehi et al 2005, Meidute Abaraviciene et al 2008.…”

Section: Introductionmentioning

confidence: 99%

Acute stimulation of glucagon secretion by linoleic acid results from GPR40 activation and [Ca2+]i increase in pancreatic islet α-cells

Wang

Zhao

Gui³

et al. 2011

Journal of Endocrinology

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The role of free fatty acids (FFAs) in glucagon secretion has not been well established, and the involvement of FFA receptor GPR40 and its downstream signaling pathways in regulating glucagon secretion are rarely demonstrated. In this study, it was found that linoleic acid (LA) acutely stimulated glucagon secretion from primary cultured rat pancreatic islets. LA at 20 and 40 mmol/l dose-dependently increased glucagon secretion both at 3 mmol/l glucose and at 15 mmol/l glucose, although 15 mmol/l glucose reduced basal glucagon levels. LA induced an increase in cytoplasmic free calcium concentrations (

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The short-term effect of fatty acids on glucagon secretion is influenced by their chain length, spatial configuration, and degree of unsaturation: studies in vitro

Cited by 37 publications

References 47 publications

GPR40 is expressed in glucagon producing cells and affects glucagon secretion

GPR40 is expressed in glucagon producing cells and affects glucagon secretion

Physiology of the pancreatic α-cell and glucagon secretion: role in glucose homeostasis and diabetes

Acute stimulation of glucagon secretion by linoleic acid results from GPR40 activation and [Ca2+]i increase in pancreatic islet α-cells

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