The Short-Term Effect of Nifedipine Tocolysis on Placental, Fetal Cerebral, and Atrioventricular Doppler Waveforms

Effects of betamethasone on fetoplacental and maternal hemodynamics in preterm pregnancies

“…In the present study, all patients received only a loading dose of nifedipine within 1 hour without a maintenance dose owing to the cessation of uterine contractions. Moreover, the peak plasma concentration of nifedipine is reached after 1 hour and its half‐life is approximately 3 hours, whereas the highest serum concentration of betamethasone is seen 36 hours after the first dose and betamethasone continues to be effective for to 5–7 days in pregnant women . In addition, all women in the present study received the second betamethasone dose 24 hours after the first dose.…”

“…Several studies have investigated the possible effects of nifedipine on fetomaternal blood flow . Two previous studies reported that nifedipine does not cause a significant change in uteroplacental and fetal Doppler parameters.…”

Major Sacrococcygeal Teratoma in an Extreme Premature Infant: A Multidisciplinary Approach

“…Animal studies suggest that administration of a calcium channel blocker may impair uterine blood flow, potentially resulting in altering the hemodynamic situation of the fetus and increasing cardiac failure. However, in human studies no apparent reduction in uteroplacental blood flow was detected and no adverse effects were noted in the fetus or newborn [14,15] .…”

Uteroplacental Blood Flow

“…48 Nifedipine is now considered the drug of choice for short-term tocolysis in preterm labor by many authorities. This drug has been studied in humans with Doppler estimation of effects on uteroplacental blood flow and no significant changes were noted following nifedipine loading of up to 40 mg. 49 β-Adrenergic Blocking Drugs. Maternally administered esmolol produces β-adrenergic blockade and hypoxemia in fetal sheep, although the effect on uteroplacental blood flow was not measured.…”