The short-term effect of smoking on fetal ECG

Péterfi, István; Kellényi, L; Péterfi, Lehel; Szilágyi, András

doi:10.1080/14767058.2017.1390560

Cited by 7 publications

(6 citation statements)

References 12 publications

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“…Consistent with the initial report, the current reanalysis of this data set showed larger values of the category lAMP. -Acute maternal cigarette smoking reduced fetal HRV (Graca et al, 1991;Peterfi et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Heart rate variability categories of fluctuation amplitude and complexity: diagnostic markers of fetal development and its disturbances

et al. 2019

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Fetal development and its disturbances have been reported to be associated with a multiplicity of HRV indices. Furthermore, these HRV indices change with maturation. We propose the abstraction of HRV categories defined by short-and long-term fluctuation amplitude, complexity, and pattern indices that cover all relevant aspects of maturational age, behavioral influences and a series of pathological disturbances. The study data are provided by multiple centers. Our approach is an important step towards the goal of a standardized diagnostic tool for early identification of fetal developmental disturbances with respect to the reduction of serious complications in the later life.

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Section: Discussionmentioning

confidence: 99%

Heart rate variability categories of fluctuation amplitude and complexity: diagnostic markers of fetal development and its disturbances

et al. 2019

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“…Studies reporting the effects of PTE on HR and HRV have also demonstrated mixed results. Prior studies have either reported an increase in fetal HR from acute exposure to maternal smoking ( Quigley et al, 1979 ; Kelly et al, 1984 ; Péterfi et al, 2019 ) or no statistically significant difference in fetal HR after acute exposure to maternal smoking ( Barrett et al, 1981 ; Goodman et al, 1984 ; Oncken et al, 2002 ). Additionally, prior studies have reported decreased HRV in response to acute maternal smoking ( Eriksen et al, 1984 ; Goodman et al, 1984 ; Péterfi et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

“…Prior studies have either reported an increase in fetal HR from acute exposure to maternal smoking ( Quigley et al, 1979 ; Kelly et al, 1984 ; Péterfi et al, 2019 ) or no statistically significant difference in fetal HR after acute exposure to maternal smoking ( Barrett et al, 1981 ; Goodman et al, 1984 ; Oncken et al, 2002 ). Additionally, prior studies have reported decreased HRV in response to acute maternal smoking ( Eriksen et al, 1984 ; Goodman et al, 1984 ; Péterfi et al, 2019 ). Investigations of fetal HR and HRV in chronic maternal smokers reported decreased baseline fetal HR compared to controls and reduced HRV ( Kapaya et al, 2014 ; Spyridou et al, 2017 ; Zeskind and Gingras, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of Prenatal Exposure to Alcohol and Smoking on Fetal Heart Rate and Movement Regulation

Lucchini¹,

Shuffrey²,

Nugent³

et al. 2021

Front. Physiol.

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Negative associations of prenatal tobacco and alcohol exposure (PTE and PAE) on birth outcomes and childhood development have been well documented, but less is known about underlying mechanisms. A possible pathway for the adverse fetal outcomes associated with PTE and PAE is the alteration of fetal autonomic nervous system development. This study assessed PTE and PAE effects on measures of fetal autonomic regulation, as quantified by heart rate (HR), heart rate variability (SD-HR), movement, and HR-movement coupling in a population of fetuses at ≥ 34 weeks gestational age. Participants are a subset of the Safe Passage Study, a prospective cohort study that enrolled pregnant women from clinical sites in Cape Town, South Africa, and the Northern Plains region, United States. PAE was defined by six levels: no alcohol, low quit early, high quit early, low continuous, moderate continuous, and high continuous; while PTE by 4 levels: no smoking, quit early, low continuous, and moderate/high continuous. Linear regression analyses of autonomic measures were employed controlling for fetal sex, gestational age at assessment, site, maternal education, household crowding, and depression. Analyses were also stratified by sleep state (1F and 2F) and site (South Africa, N = 4025, Northern Plains, N = 2466). The final sample included 6491 maternal-fetal-dyad assessed in the third trimester [35.21 ± 1.26 (mean ± SD) weeks gestation]. PTE was associated with a decrease in mean HR in state 2F, in a dose dependent fashion, only for fetuses of mothers who continued smoking after the first trimester. In state 1F, there was a significant increase in mean HR in fetuses whose mother quit during the first trimester. This effect was driven by the Norther Plains cohort. PTE was also associated with a significant reduction in fetal movement in the most highly exposed group. In South Africa a significant increase in mean HR both for the high quit early and the high continuous group was observed. In conclusion, this investigation addresses a critical knowledge gap regarding the relationship between PTE and PAE and fetal autonomic regulation. We believe these results can contribute to elucidating mechanisms underlying risk for adverse outcomes.

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“…Measures of change in fetal autonomic system (ANS) activity, which is modulated by fetal behavioral state, serve as a practical and non-invasive index for assessment of fetal brain functional development. These measures have also been implemented to study the impact of maternal clinical disorders, exposures, or other occurrences during gestation such as maternal depression (13), maternal stress (14), maternal smoking (15–19), maternal alcohol consumption (20–23), and the effect of aerobic exercise on the developing fetus (24). Measures of HR, HRV, and movement vary significantly by fetal behavioral state (25, 26), therefore accounting for state is imperative for the identification of potential developmental abnormalities.…”

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confidence: 99%

Fetal heart rate, heart rate variability, and heart rate/movement coupling in the Safe Passage Study

Shuffrey

et al. 2019

J Perinatol

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Structured Abstract Objective: To determine normative values for heart rate patterns in healthy fetuses. Methods: This research is from the Safe Passage Study conducted by the Prenatal Alcohol and SIDS and Stillbirth (PASS) Network. A standardized protocol assessed fetal heart rate (FHR), heart rate variability (HRV), and movement from 1,655 fetuses at three time points during gestation (20–24 weeks, 28–32 weeks, 34–38 weeks gestation). Results: FHR decreased while HRV increased over gestation. At the latter two ages, males had significantly lower FHR than females while there were no sex differences in FHR at 20–24 weeks. When accounting for fetal state during late gestation (34–28 weeks), we found that males had significantly lower FHR than females in the active fetal state only. Conclusion: Results demonstrate significant state, gestational age, and sex related changes in cardiac activity, somatic activity, and autonomic function as the fetus approaches birth.

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The short-term effect of smoking on fetal ECG

Cited by 7 publications

References 12 publications

Heart rate variability categories of fluctuation amplitude and complexity: diagnostic markers of fetal development and its disturbances

Heart rate variability categories of fluctuation amplitude and complexity: diagnostic markers of fetal development and its disturbances

Effects of Prenatal Exposure to Alcohol and Smoking on Fetal Heart Rate and Movement Regulation

Fetal heart rate, heart rate variability, and heart rate/movement coupling in the Safe Passage Study

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