The “short-term” iron rhythm

Werkman, H.P.T.; Trubels, J.M.F.; Schretlen, E. D. A. M.

doi:10.1016/0009-8981(74)90352-0

Cited by 9 publications

(1 citation statement)

References 3 publications

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“…38,39 Limitations with the TSAT lie mainly in the variability in serum iron, which can vary in an individual by as much as 40% within a single day. 40,41 This is a result of the diurnal variation seen with measuring serum iron, which leads to higher TSAT percentages in the morning and lower values in the evening. 38 Other limitations of the TSAT test are recognized during periods of acute and chronic inflammation in which it is decreased; however, marrow dysfunction due to ethanol ingestion, chemotherapy, or a megaloblastic process may actually lead to an increase in TSAT percentage.…”

Section: Transferrin Saturationmentioning

confidence: 99%

Intravenous Iron Therapy: A Summary of Treatment Options and Review of Guidelines

Silverstein

Gilreath

Rodgers

2008

Journal of Pharmacy Practice

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Iron replacement for iron-deficiency anemia has historically been accomplished with the use of oral iron therapy. Although oral iron is appropriate for most iron-deficiency anemia patients, many patients do not respond to or may be intolerant of oral iron, or may experience bleeding of sufficient magnitude to require higher iron doses than that achievable with oral iron. Intravenous iron therapy is a useful option for these latter patients. Three intravenous iron products are recommended: low-molecular weight iron dextran (INFeD), ferric gluconate (Ferrlecit), and iron sucrose (Venofer). These intravenous iron products have superior safety profiles compared to high-molecular weight iron dextran. The Food and Drug Administration's approval of erythropoietic-stimulating agents to treat certain types of anemia has increased usage of intravenous iron for functional iron deficiency. This review summarizes the current status of intravenous iron products and discusses their advantages and disadvantages in treating both absolute and functional iron deficiency.

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Section: Transferrin Saturationmentioning

confidence: 99%