The short vitamin D receptor is associated with increased risk for generalized aggressive periodontitis

Park, Kyung Sook; Nam, Jung Hyun; Choi, Jeomil

doi:10.1111/j.1600-051x.2006.00944.x

Cited by 49 publications

(54 citation statements)

References 32 publications

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“…This data was confirmed by the study of Naito and could be explained by the fact that ff genotype seems to be responsible for an increased bone re-absorption and an enhanced inflammatory response (37,41). On the contrary, the study of Li and co-authors highlights as the Chinese patients showing the F allele have an increased risk of developing generalized aggressive periodontitis (42).…”

Section: Fokimentioning

confidence: 66%

Vitamin D: relevance in dental practice

Martelli¹

2014

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SummaryObjective. The potential role of VDR gene variations in modulating periodontal susceptibility have been a subject of scientific investigations. The aim of this paper is to perform a literature review of the potential correlation between Vitamin D Receptor (VDR) gene polymorphisms and periodontal disease. Materials and methods. A PubMed literature search was made using "vitamin d receptor polymorphisms periodontal disease" as keys words. Only clinical studies in "Humans" as species and "English" as language were considered. Titles and abstracts of all identified records were examined to determine if the candidate articles contained sufficient information on the association of the VDR polymorphisms and the risk of development periodontal disease. Conclusions. Vitamin D may affect the risk of developing periodontal disease via an effect on bone mineral density or via immunomodulatory effects. There are scientific evidences about the correlation between some VDR polymorphisms, periodontitis and bone metabolism. The use of new simple and economics diagnostic techniques of genetic screening, allows to the dental specialists to identify periodontal patients with possible decreased bone mineral density. The complete acquisition of awareness by dentists of the strong relationship between skeletal bone density with periodontal health and osteointegrated implant success, could open a new therapeutic approach for periodontists with an important role in the early detection of osteoporosis and a better patient compliance of the periodontal therapy.

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Section: Fokimentioning

confidence: 66%

Vitamin D: relevance in dental practice

Martelli¹

2014

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“…In line, Naito et al (2007) reported that heterozygous Ff individuals had a lower risk of severe chronic periodontitis than individuals without the F allele (Naito et al, 2007). On the contrary, Li et al (2008) reported that F allele increased the susceptibility of aggressive periodontitis in Chinese (Li et al, 2008) and Park, Nam, and Choi (2006) reported that CC genotype associated with increased risk for generalized aggressive periodontitis in Koreans (Park et al, 2006). However, several studies have also reported no association between rs2228570 and periodontis (Wang, Zhang, & Chen, 2015; Wang et al, 2009; El Jilani et al, 2015; Tachi et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Inflammatory mediator polymorphisms associate with initial periodontitis in adolescents

Heikkinen

Kettunen

Kovanen

et al. 2016

Clinical & Exp Dental Res

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Several studies have addressed cytokine gene polymorphisms and their possible associations with periodontitis. We examined the association between salivary anti‐ and pro‐inflammatory mediator polymorphisms and initial periodontitis in Finnish adolescents, taking into account the effect of smoking. Salivary samples of 93 clinically examined adolescents from Eastern Finland were analyzed. Their oral health and smoking habits were recorded. Periodontal probing depth (PPD), and bleeding on probing (BOP) at four sites per tooth, root calculus (RC), and visible plaque index (VPI) were recorded from the index teeth. Salivary MMP‐8 median values were assessed. The sites with ≥4 mm PD were categorized as follows: PPD1 = one or more ≥4 mm pocket, PPD2 = two or more ≥4 mm pockets, and PPD3 = three or more ≥4 mm pockets. Genomic DNA was extracted from 300 μl of the saliva samples by genomic QIAamp® DNA Blood Mini Kit and genotyped for polymorphisms. Genetic variants for genotyping were selected from the following genes of interest: S100A8, FCGR2A, FCGR2B, IL10, MMP8, MMP3, MMP13, VDR, TLR4, MMP2, MPO, ELANE, IL1A, IL1B, IL1RN, CD28, MMP9, DDX39B, NFKBIL1, LTA, TNF, SOD2, IL6, TLR4, TIMP1, and SYN1. After false discovery rate control (FDR), polymorphisms in MMP3 (rs679620, rs520540, rs639752), CD28 (rs3116496), and VDR (rs2228570) associated (FDR q < 0.05) with deepened periodontal pockets. Smoking did not affect the results. Genetic polymorphisms of pro‐inflammatory mediators MMP3, CD28, and VDR seem to link to initial periodontitis.

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“…The known influence of VDR on the immune response [6,7,8] may have contributed to or even accounted for the impact of the VDR rs2228570 polymorphism on allergy. Previous observations revealed an influence of the FokI VDR polymorphism on prevalance and/or clinical course of asthma [27,28], immune type 1 diabetes [77], multiple sclerosis [31], systemic lupus erythematosus [78], graft rejection [79], ulcerative colitis [40], aggressive periodontitis [30] and dengue hemorrhagic fever [80]. …”

Section: Discussionmentioning

confidence: 99%

“…Polymorphisms of VDR have been reported to be associated with bone mineral density [23] diabetes mellitus [24,25], hypertension [26], asthma [27,28], periodontitis [29,30], risk of multiple sclerosis [31,32] and malignancy [33,34,35,36,37,38]. On the other hand, several studies failed to report an impact of VDR polymorphisms on multiple sclerosis [39], inflammatory bowel disease [40], coronary artery disease [41] or malignancy [42,43,44].…”

Section: Introductionmentioning

confidence: 99%

Impact of Vitamin D Receptor VDR rs2228570 Polymorphism in Oldest Old

Glocke

Läng

Schaeffeler

et al. 2013

Kidney Blood Press Res

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Background: Calcitriol, a key player in the regulation of mineral metabolism, influences, directly or by increasing plasma Ca²⁺ and phosphate levels, a multitude of physiological functions, such as bone mineralization, cell proliferation, immune response, carbohydrate metabolism, blood pressure, platelet reactivity, gastric acid secretion, cognitive function and mood. Calcitriol is mainly effective by stimulation of the Vitamin D receptor VDR. The responsiveness of VDR may be affected by gene variants, such as the FokI polymorphism (rs2228570). The GG gene variant is expected to be more active than the GA or AA gene variant. The present study explored the impact of VDR rs2228570 on survival and health of oldest old individuals (> 90 years). Methods: 101 individuals > 90 years were examined and genotyped. As a result, the prevalence of GG, GA & AA was 36 (10 ♂, 26♀), 52 (24 ♂, 28♀) and 13 (4 ♂, 9♀), respectively, a prevalence not significantly different from the frequency in public available dbSNP and a population (n = 208) of young volunteers (average age 49 years). Results: As compared to carriers of GG, carriers of AA and/or GA displayed significantly (p<0.05) lower diastolic blood pressure (significant only in ♂), higher instrumental activity of daily life (IADL) score and more frequent hospital visits (significant only in ♂), significantly lower prevalence of depression (significant in ♀+♂), renal disease (significant only in ♀), allergy, peptic ulcer and urolithiasis (significant only in ♂), as well as significantly higher prevalence of transitoric ischemic attacks. In a younger population a German version of the NEO-FFI, allowing reliable and valid assessment of personality, revealed decreased neuroticism (significant only in ♂) and increased extraversion in AA carriers. Conclusion: The Vitamin D receptor gene variant VDR rs2228570 has only little impact on life span but may affect a variety of pathophysiologically relevant functions including mood.

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The short vitamin D receptor is associated with increased risk for generalized aggressive periodontitis

Abstract: These results demonstrate that the short VDR (27823C/C) protein may influence GAP susceptibility.

Cited by 49 publications

References 32 publications

Vitamin D: relevance in dental practice

Vitamin D: relevance in dental practice

Inflammatory mediator polymorphisms associate with initial periodontitis in adolescents

Impact of Vitamin D Receptor VDR rs2228570 Polymorphism in Oldest Old

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The short vitamin D receptor is associated with increased risk for generalized aggressive periodontitis

Abstract: These results demonstrate that the short VDR (27823*C/*C) protein may influence GAP susceptibility.

Cited by 49 publications

References 32 publications

Vitamin D: relevance in dental practice

Vitamin D: relevance in dental practice

Inflammatory mediator polymorphisms associate with initial periodontitis in adolescents

Impact of Vitamin D Receptor VDR rs2228570 Polymorphism in Oldest Old

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Abstract: These results demonstrate that the short VDR (27823C/C) protein may influence GAP susceptibility.