The shortened replicative life span of prohibitin mutants of yeast appears to be due to defective mitochondrial segregation in old mother cells

Piper, Peter W.; Jones, Gary W.; Bringloe, David; Harris, Nicholas; MacLean, Morag; Mollapour, Mehdi

doi:10.1046/j.1474-9728.2002.00018.x

Cited by 71 publications

(59 citation statements)

References 51 publications

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“…Furthermore, additional roles of cell growth regulators will probably emerge in screens for ostensibly unrelated phenotypes. In one example, recent systematic screens also suggest that TOR and Sch9 activities limit yeast replicative capacity and survival [31 ,32], at least in rich medium [33]. Our appreciation of the global growth regulatory network and its connections to various cellular subsystems will continue to evolve with new systematic datasets.…”

Section: Yeast Rises To the Size Challenge Againmentioning

confidence: 98%

Size control goes global

Cook

Tyers

2007

Current Opinion in Biotechnology

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Section: Yeast Rises To the Size Challenge Againmentioning

confidence: 98%

Size control goes global

Cook

Tyers

2007

Current Opinion in Biotechnology

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“…Mitochondrial damage has also been taken into account as a potential course of yeast replicative aging (Jazwinski 2000;Piper et al 2002) but divergent results of studies of rho o mutants (Kaeberlein et al 2005a, b) do not allow for drawing unequivocal conclusions concerning the role of mitochondria as a factor limiting the ability of yeast cells to reproduce.…”

Section: Introductionmentioning

confidence: 98%

Cell volume as a factor limiting the replicative lifespan of the yeast Saccharomyces cerevisiae

et al. 2008

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The number of cell divisions of the yeast Saccharomyces cerevisiae is limited, referred to as "replicative lifespan" of this organism and believed to be due to aging mechanisms similar to those of mammalian cells. We demonstrate, using three pairs of isogenic yeast strains (standard and a mutant deficient in an antioxidant defense protein) that although the lifespan differs significantly, the final volume attained after the last division is similar within each pair of strains. In a population, cells cease to bud after various number of cell cycles but attaining a similar final volume. These results indicate that the increase in the mother cell volume, intrinsic to the asymmetric cell division in S. cerevisiae, may be the main mechanism limiting the reproductive capacity of in this organism.

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“…alter mitochondrial morphology in aged cells (34). Further, in C. elegans, knockdown of PHB proteins induces abnormal mitochondrial morphology (17).…”

Section: Mitochondrial Functions Of Phb2mentioning

confidence: 99%

Mitochondrial Functions and Estrogen Receptor-dependent Nuclear Translocation of Pleiotropic Human Prohibitin 2

Kasashima

Ohta

Kagawa

et al. 2006

Journal of Biological Chemistry

190

215

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Proteins with multiple cellular functions provide biological diversity to eukaryotic cells. In the current studies, we identified the mitochondrial functions of human prohibitin 2 (PHB2), which was initially identified as a repressor of estrogen-dependent transcriptional activity. The mitochondrial complex of PHB2 consists of PHB1, voltage-dependent anion channel 2, adenine nucleotide translocator 2, and the anti-apoptotic Hax-1, which is a novel binding partner for PHB2. RNA interference-mediated knockdown of PHB2 in HeLa cells resulted in caspase-dependent apoptosis through down-regulation of Hax-1 and fragmentation of mitochondria. We also found that, although PHB2 is predominantly expressed in the mitochondria of HeLa cells, it translocates to nucleus in the presence of estrogen receptor ␣ and estradiol. Here, we first demonstrated the roles of mammalian PHB2 in mitochondria and the molecular mechanism of its nuclear targeting and showed that PHB2 is a possible molecule directly coupling nuclear-mitochondrial interaction.

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The shortened replicative life span of prohibitin mutants of yeast appears to be due to defective mitochondrial segregation in old mother cells

Abstract: Summary

Cited by 71 publications

References 51 publications

Size control goes global

Size control goes global

Cell volume as a factor limiting the replicative lifespan of the yeast Saccharomyces cerevisiae

Mitochondrial Functions and Estrogen Receptor-dependent Nuclear Translocation of Pleiotropic Human Prohibitin 2

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