The shrunken pore syndrome is associated with declined right ventricular systolic function in a heart failure population – the HARVEST study

Abstract

The shrunken pore syndrome is associated with declined right ventricular systolic function in a heart failure population -the HARVEST study Christensson, Anders; Grubb, Anders; Molvin, John; Holm, Hannes; Gränsbo, Klas; Tasevska-Dinevska, Gordana; Bachus, Erasmus; Jujic, Amra; Magnusson, Martin Christensson, A., Grubb, A., Molvin, J., Holm, H., GRÄNSBO, K. L. A. S., Tasevska-Dinevska, G., ... Magnusson, M. (2016). The shrunken pore syndrome is associated with declined right ventricular systolic function in a heart failure population -the HARVEST study. Scandinavian Journal of Clinical & Laboratory Investigation, 76(7), 568-574. DOI: 10.1080DOI: 10. /00365513.2016 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal 1The Shrunken pore syndrome is associated with declined right ventricular systolic function in a heart failure population -the HARVEST study AbstractThe close relationship between heart and kidney diseases was studied with respect to the "Shrunken pore syndrome" that is characterized by a difference in renal filtration between cystatin C and creatinine. Patients were retrieved from the HeARt and brain failure inVESTigation trail (HARVEST) which is an ongoing study undertaken in individuals hospitalized for the diagnosis of heart failure. Ninety-five of 116 patients who underwent transthoracic echocardiograms (TTE) were eligible for this study. We In conclusion, heart failure patients with the "Shrunken pore syndrome" are at increased risk of having RV systolic dysfunction whilst heart failure patients without "Shrunken pore syndrome" seem protected. These findings may indicate common pathophysiological events in the kidneys and the heart explaining the observed increased risk of mortality in subjects with the "Shrunken pore syndrome".3

Cardiovascular biomarkers predict post‐discharge re‐hospitalization risk and mortality among Swedish heart failure patients

“…A total of 90 patients were re-hospitalized (median followup time, 5 months; IQR [1][2][3][4][5][6][7][8][9][10][11][12]) because of cardiac causes. The most common cardiac causes of re-hospitalization were HF (n = 79) followed by cardiac arrhythmia (n = 10) and myocardial infarction (n = 1).…”

“…The HeARt and Brain Failure inVESTigation project in Malmö, Sweden (HARVEST-Malmö), is an ongoing study undertaken in patients hospitalized for HF (ICD-10: I50-) in Skåne University Hospital, Malmö. 4,5 The inclusion criteria for the HARVEST study are admission to the Department of Cardiology or Internal Medicine for treatment of newly diagnosed or exacerbated HF. The only exclusion criterion is the inability to give informed consent.…”

The mortality increase in cardiac surgery patients associated with shrunken pore syndrome correlates with the eGFRcystatin C/eGFRcreatinine-ratio

“…Instead, different cut-off levels should be applied to the two equation pairs, and the best trade-off between sensitivity and specificity yields higher cut-off levels. Also, SPS has been associated with other conditions such as right ventricular dysfunction in heart failure [8], and different cut-off levels could apply to this and other conditions.…”

“…SPS has been shown to be a risk factor for early and midterm mortality (2-5 years) independent of eGFR [2][3][4]. The condition was originally presumed to be present in late pregnancy and particularly in pre-eclampsia [5][6][7], but was later found to be present in all patient populations studied [2][3][4]8]. In the first study showing that SPS was a risk factor for mortality, the value of the eGFR cystatin C /eGFR creatinine -ratio used to identify SPS was set to 0.6 [1].…”

Autonomic dysfunction is associated with cardiac remodelling in heart failure patients

“…The Heart and Brain Failure Investigation (HARVEST) study is an ongoing study undertaken in patients hospitalized for the diagnosis of HF in the city of Malmö, Sweden. 13 The inclusion criteria for the HARVEST study are admission to the department of internal medicine or cardiology for treatment of newly diagnosed or exacerbated chronic HF. The only exclusion criterion is the inability to deliver oral or written consent.…”