The side effects of phototherapy for neonatal jaundice: what do we know? What should we do?

Xiong, Tao; Qu, Yi; Cambier, Stephanie; Mu, Dezhi

doi:10.1007/s00431-011-1454-1

Cited by 115 publications

(86 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, after correcting for congenital and chromosomal abnormalities, the associations were no longer statistically significant [17,18]. Additionally, previous studies could not find an association between phototherapy and skin cancer [16,19]. Phototherapy does seem to be associated with the development of allergic diseases [20].…”

Section: Intensive Phototherapymentioning

confidence: 87%

See 1 more Smart Citation

Neonatal management and outcome in alloimmune hemolytic disease

Ree

Smits-Wintjens

Bom

et al. 2017

Expert Review of Hematology

103

View full text Add to dashboard Cite

Introduction: Hemolytic disease of the fetus and newborn (HDFN) occurs when fetal and neonatal erythroid cells are destroyed by maternal erythrocyte alloantibodies, it leads to anemia and hydrops in the fetus, and hyperbilirubinemia and kernicterus in the newborn. Postnatal care consists of intensive phototherapy and exchange transfusions to treat severe hyperbilirubinemia and top-up transfusions to treat early and late anemia. Other postnatal complications have been reported such as thrombocytopenia, iron overload and cholestasis requiring specific management. Areas covered: This review focusses on the current neonatal management and outcome of hemolytic disease and discusses postnatal treatment options as well as literature on long-term neurodevelopmental outcome. Expert commentary: Despite major advances in neonatal management, multiple issues have to be addressed to optimize postnatal management and completely eradicate kernicterus. Except for strict adherence to guidelines, improvement could be achieved by clarifying the epidemiology and pathophysiology of HDFN. Several pharmacotherapeutic agents should be further researched as alternative treatment options in hyperbilirubinemia, including immunoglobulins, albumin, phenobarbital, metalloporphyrins, zinc, clofibrate and prebiotics. Larger trials are warranted to evaluate EPO, folate and vitamin E in neonates. Long-term follow-up studies are needed in HDFN, especially on thrombocytopenia, iron overload and cholestasis.ARTICLE HISTORY

show abstract

Section: Intensive Phototherapymentioning

confidence: 87%

“…Phototherapy is generally considered a safe procedure and reports of significant toxicity are exceptionally rare and mostly limited to case reports [10,16]. Recently, two studies were published on a possible link between phototherapy and development of cancer.…”

Section: Intensive Phototherapymentioning

confidence: 99%

Neonatal management and outcome in alloimmune hemolytic disease

Ree

Smits-Wintjens

Bom

et al. 2017

Expert Review of Hematology

103

View full text Add to dashboard Cite

show abstract

“…Adverse effects such as water loss, skin rash, and retinal damage were not serious and preventable [15]. Although unresolved, an association between neonatal phototherapy and skin cancer/other cancer was reported [8,9].…”

Section: Discussionmentioning

confidence: 99%

Neonatal Phototherapy: A Novel Therapy to Prevent Allergic Skin Disease for At Least 5 Years

2018

Neonatology

View full text Add to dashboard Cite

Background: Preventing the development of allergic skin disease in children is the best way to treat the disease. Objectives: Ultraviolet (UV)-free blue light phototherapy has been reported to treat atopic eczema. We evaluated the effect of neonatal phototherapy on allergic skin disease in children. Methods: We randomly recruited 117,041 children from an insurance research database. Those with neonatal jaundice and receiving neonatal phototherapy were classified as the icteric-phototherapy group (n = 4,744), those with neonatal jaundice and not receiving phototherapy were classified as the icteric-non-phototherapy group (n = 5,003), and those without jaundice were classified as the non-icteric group (n = 107,294). We reviewed claims from birth to age 5 years. The prevalence of atopic dermatitis (AD), clinical visit times, and topical prescriptions for allergic skin disease at different ages were compared among groups. Results: AD prevalence was lower in the icteric-phototherapy group than in the icteric-non-phototherapy group. Moreover, clinical visit times for allergic skin disease were lower at age 1–4 years, and topical agent prescription for allergic skin disease were lower at age 1–5 years, in the icteric-phototherapy group than in the icteric-non-phototherapy group. The decreased use of topical agents could reach 64.29%. The 5-year complications of skin disease and cancer in the phototherapy group were not higher. Conclusions: To our knowledge, this is the first study to report on the effect of UV-free blue light therapy on allergic skin disease in newborns. Blue light therapy in newborns may be a novel method to efficiently prevent allergic skin disease for at least 5 years.

show abstract

“…Untreated severe unconjugated hyperbilirubinemia is potentially neurotoxic. 4,5 Hypocalcemia is one of the lesser known but potential adverse effect of phototherapy. Neonatal hypocalcemia is defined as total serum calcium concentration of <7 mg/dl.…”

Section: Introductionmentioning

confidence: 99%

Effect of phototherapy on serum calcium level in term newborns

Rozario

Pillai

Ranamol

2017

Int J Contemp Pediatr

View full text Add to dashboard Cite

Background: Hyperbilirubinemia is one of the most prevalent problems in neonates. Jaundice is observed during first week of life in approximately 60% of term neonates and 80 % of preterm neonates. Phototherapy is one of the routine methods for management of hyperbilirubinemia. The aim of this study is to assess the effect of phototherapy on serum calcium level in term newborns with neonatal hyperbilirubinemia who undergo phototherapy and to find out the association between effect of phototherapy on serum calcium level and birth weight, postnatalage, type of feeding and blood group incompatibility.Methods: 100 newborns with neonatal hyperbilirubinemia admitted in newborn nursery were selected for the study. Serum calcium estimation was done before phototherapy. All newborns were subjected to double surface phototherapy. After 48 hours of phototherapy serum calcium was estimated and compared with earlier value.Results: Out of 100 newborns studied 67 babies had a decrease in serum calcium level after 48 hrs of phototherapy. And this reduction in calcium level was found to be statistically significant (p value <0.001). Only 3 babies developed hypocalcemia (serum calcium <7 mg/dl). None of them were symptomatic. There was no significant association between reduction in serum calcium level and birth weight, postnatalage, type of feeding and blood group incompatability.Conclusions: There is signiticant reduction in serum calcium level after phototherapy but risk of hypocalcemia is low in healthy full-term neonates. No significant association was found between reduction in serum calcium level and birth weight, postnatal age,type of feed, and blood group incompatibility.

show abstract

The side effects of phototherapy for neonatal jaundice: what do we know? What should we do?

Cited by 115 publications

References 88 publications

Neonatal management and outcome in alloimmune hemolytic disease

Neonatal management and outcome in alloimmune hemolytic disease

Neonatal Phototherapy: A Novel Therapy to Prevent Allergic Skin Disease for At Least 5 Years

Effect of phototherapy on serum calcium level in term newborns

Contact Info

Product

Resources

About