The sign of leser-trélat: think in the adenocarcinoma of the lung

Asri, Hanane; Soualhi, M.

doi:10.11604/pamj.2018.30.270.16337

Cited by 10 publications

(14 citation statements)

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“…The Leser–Trélat sign is characterized by the sudden appearance of multiple (often pruritic) SKs in association with an underlying malignancy. A great number of tumors, such as lung cancer, esophageal carcinoma, nasopharyngeal carcinoma, mycosis fungoides, Sézary syndrome, and plasmacytoma, have been described in association with this paraneoplastic disorder 36– 41 . Tumor screening is recommended in case of abrupt development of multiple pruritic SKs.…”

Section: Pathogenesismentioning

confidence: 99%

Recent advances in managing and understanding seborrheic keratosis

Wollina

2019

F1000Res

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Seborrheic keratosis (SK) is a common benign epidermal tumor with predominance in adult patients. Whereas common SKs are more frequent in Caucasians, dermatosis papulosa nigra is more prevalent in patients with a Fitzpatrick skin type of at least 3. There seems to be a link between extrinsic skin aging and the occurrence of SK. Mutations of fibroblast growth factor receptor 3 and other signaling molecules are a frequent finding in SK lesions. However, this does not translate into any malignant potential. Viral infections are particularly common in genital lesions, although their pathogenetic relevance for SK is questionable. Different histologic and clinical subtypes have been identified. The great variability of SKs raises some difficulties in diagnosis. Dermoscopy is the preferred non-invasive diagnostic method, in particular to differentiate pigmented SKs from other pigment tumors, including cutaneous melanoma. Eruptive SKs can be a paraneoplastic condition known as the Leser–Trélat sign. New targeted cancer treatments can cause a pseudo-Leser–Trélat sign. The treatment in practice is mainly minor surgery, including cryosurgery, shave excisions, and laser-assisted removal. The medical approaches have only limited effects. Recently, two formulations for topical therapy have been evaluated: a product with 40% hydrogen peroxide (HP40) and an aqueous nitric–zinc complex. Based on clinical trials, HP40 seems to be a promising alternative to surgery, in particular for facial lesions.

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Section: Pathogenesismentioning

confidence: 99%

Recent advances in managing and understanding seborrheic keratosis

Wollina

2019

F1000Res

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“…The exact underlying pathogenesis remains unknown. More recent observations have shown a correlation between the release of TGF-alpha and EGF from malignant cells and the rapid proliferation of keratinocytes in the lesional syndrome [7].…”

Section: Sirmentioning

confidence: 97%

“…A careful search for an underlying malignancy should be undertaken. A physical examination with a complete blood count, serum biochemistry, chest X-ray, mammogram, Pap smear, PSA screening, upper GI endoscopy, and colonoscopy is required during this examination [5][6][7].…”

Section: Case Lettermentioning

confidence: 99%

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Leser–Trélat syndrome: What does it hide?

Dassouli¹,

Douhi²,

Tahri³

et al. 2022

Our Dermatol Online

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Sir, Seborrheic keratoses (SKs) are common, benign, non-melanocytic epidermal tumors [1]. Still, they may be suspicious of other, more serious underlying conditions. Leser–Trélat syndrome may be considered a paraneoplastic condition characterized by the sudden onset of multiple SKs [2]. Herein, we report two cases of malignancy revealed by eruptive KS. The first case, an 83-year-old male with no notable pathological history, presented for two years with rapidly evolving lesions of the trunk over a six-month period. The patient also noticed for three months melena with transit disorders, justifying a consultation in which the diagnosis of sigmoid tumor was reached and the patient was referred for surgery. A clinical examination revealed multiple, sessile, exophytic tumors of round or oval appearance, 1 to 3 cm in diameter, well-delimited. The surface of the lesions was verrucous, brownish-black, with numerous, black, keratotic plugs (Fig. 1a). A dermoscopic examination revealed a cerebral appearance with pseudocysts and pseudocomedones (Fig. 1b). The diagnosis of seborrheic keratosis was thus reached.

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“…More than 50% of associated malignancies are adenocarcinomas, especially those of the stomach, colon, rectum, and breast, 1 although this sign has also been reported in other malignancies, including lung cancer. 2 The association of the Leser-Trélat sign with malignancy is debatable, with suggestions that the sign may exist independent of an underlying occult malignancy or may be associated with nonmalignant conditions such as benign neoplasms, pregnancy, or human immunodeficiency virus infection. 3,4 The exact pathogenesis of the Leser-Trélat sign is unclear.…”

Section: ■ Eruptive Seborrheic Keratosismentioning

confidence: 99%

Eruptive seborrheic keratosis: A perilous clue

Kaushik

Daroach

et al. 2021

CCJM

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Eruptive seborrheic keratosis: A perilous clueA 51-year-old man presented with a 1-month history of multiple eruptive seborrheic keratoses on his back and a single painless nodule on his chest. He reported occasional dry cough and loss of appetite over the past 3 months, but he did not seek medical care for them. He had no history of fever, weight loss, night sweats, or gastrointestinal complaints.The physical examination revealed an erythematous nodule measuring 3 cm by 3 cm in the right midaxillary line (Figure 1). The nodule was fi rm, mobile, and nontender on palpation, and it had a normal temperature. Also noted were multiple seborrheic keratoses of various sizes arranged in a "Christmas tree" pattern on his back (Figure 2). The rest of the examination was unremarkable.A punch biopsy was taken from the nodule. The histopathology report described an THE CLINICAL PICTURE

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The sign of leser-trélat: think in the adenocarcinoma of the lung

Cited by 10 publications

References 0 publications

Recent advances in managing and understanding seborrheic keratosis

Recent advances in managing and understanding seborrheic keratosis

Leser–Trélat syndrome: What does it hide?

Eruptive seborrheic keratosis: A perilous clue

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