The significance of anti-HLA antibody presence in children who lost the transplanted kidney due to vascular thrombosis

Piątosa, Barbara; Grenda, Ryszard; Rubik, Jacek; Prokurat, Sylwester

doi:10.1016/s0041-1345(01)02854-8

Cited by 2 publications

(2 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In their study, patients without donor‐specific HLA‐Ab had good graft outcomes, while the presence of pre‐ and post‐Tx donor‐specific HLA‐Ab, especially if directed against HLA class I, was associated with worse graft survival. Piatosa et al (39) described the association of HLA‐Ab with vascular thrombosis in pediatric renal allografts.…”

Section: Clinical Significance Of Hla‐abmentioning

confidence: 99%

Anti‐HLA alloantibodies in pediatric solid organ transplantation

Girnita

Webber

Zeevi

2006

Pediatric Transplantation

View full text Add to dashboard Cite

An increasing number of studies demonstrate the clinical impact of preformed and de novo anti-human leucocyte antigen alloantibody (HLA-Ab) in solid organ transplantation (Tx). The screening of HLA-Ab in candidates and transplant recipients has evolved over time, with continuous improvement in the sensitivity and specificity of assays for HLA-Ab detection. Furthermore, histologic markers of complement activation pathways are currently implemented in the diagnosis of antibody-mediated rejection (AMR). Therapeutic strategies, including depletion of HLA-Ab and B cells, have allowed Tx across antibody barriers, or have rescued patients with AMR. The purpose of the present review is to summarize the state-of-the-art of HLA-Ab detection, clinical significance and therapeutic strategies in pediatric solid organ Tx.

show abstract

Section: Clinical Significance Of Hla‐abmentioning

confidence: 99%

Anti‐HLA alloantibodies in pediatric solid organ transplantation

Girnita

Webber

Zeevi

2006

Pediatric Transplantation

View full text Add to dashboard Cite

show abstract

“…Theoretically, more concerning is the development of de novo donor‐specific anti‐HLA antibodies (DSA). In pediatric kidney transplant recipients, the development of DSA has been associated with long‐term renal allograft attrition . In adult heart transplant recipients, DSA posttransplant have been associated with increased rejection, development of coronary allograft vasculopathy (CAV) and decreased patient survival .…”

Section: Introductionmentioning

confidence: 99%

Development and Impact of De Novo Anti-HLA Antibodies in Pediatric Heart Transplant Recipients

Chen

Manlhiot

Conway

et al. 2015

American Journal of Transplantation

View full text Add to dashboard Cite

There is increasing evidence that de novo anti‐HLA antibodies, more specifically de novo donor‐specific antibodies (DSA) following solid organ transplantation may be associated with negative outcomes including rejection in the first year and graft loss. Limited data are available in pediatric heart transplant recipients. We sought to prospectively determine the incidence, class and early impact of de novo anti‐HLA antibodies in a cohort of pediatric heart transplant recipients. Serial panel reactive antibody testing posttransplant was performed in 25 patients (14 males) transplanted between January 2008 and June 2010. Five patients were sensitized pretransplant; all patients had negative direct crossmatch. Seventy‐two percent developed de novo anti‐HLA antibodies at a median of 2.6 weeks (IQR 1.2 weeks to 6.2 months) posttransplant; 67% of these were DSA. The majority of recipients in our cohort developed de novo anti‐HLA antibodies within the first year posttransplant, with two‐thirds being donor‐specific. Acute cellular rejection, though frequent, was not different in patients with antibody development regardless of class or specificity, and there was no antibody‐mediated rejection, graft loss or early cardiac allograft vasculopathy.

show abstract

The significance of anti-HLA antibody presence in children who lost the transplanted kidney due to vascular thrombosis

Cited by 2 publications

References 3 publications

Anti‐HLA alloantibodies in pediatric solid organ transplantation

Anti‐HLA alloantibodies in pediatric solid organ transplantation

Development and Impact of De Novo Anti-HLA Antibodies in Pediatric Heart Transplant Recipients

Contact Info

Product

Resources

About