The significance of autoantibodies against oxidatively modified low-density lipoprotein (LDL) in patients with psoriasis

Örem, Asım; Çimşit, Gülseren; Örem, Cihan; Vanizor, Birgül

doi:10.1016/s0009-8981(99)00062-5

Cited by 36 publications

(31 citation statements)

References 24 publications

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“…Elevated levels of anti-oxLDL antibodies were found in patients with autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, and APS, 16,26,30,[72][73][74][75][76][77][78][79][80][81][82][83][84] as well as in other conditions such as diabetes mellitus, 71 uremia, 77 chronic periaortitis, hepatocellular carcinoma, ␤-thalassemia, psoriasis, and preeclampsia and eclampsia (Table 2).…”

Section: Pathogenic Role Of Anti-oxldl Antibodies In Humansmentioning

confidence: 99%

Are Anti–Oxidized Low-Density Lipoprotein Antibodies Pathogenic or Protective?

et al. 2004

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Section: Pathogenic Role Of Anti-oxldl Antibodies In Humansmentioning

confidence: 99%

Are Anti–Oxidized Low-Density Lipoprotein Antibodies Pathogenic or Protective?

et al. 2004

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“…In these regard, antibodies recognizing oxidized LDL is reported to correlate with disease severity. 6,22 Interestingly, macrophages activated by engulfing LDL immune complexes release large quantities of tumor necrosis factor (TNF-α) and IL-1β. 23 Cytokine driven inflammation and tissue destruction is a common theme of chronic inflammatory disease.…”

Section: Resultsmentioning

confidence: 99%

Dyslipidemia in psoriasis: as a risk for cardiovascular disease

Dsouza

Kuruville

2013

Int J Res Med Sci

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INTRODUCTIONPsoriasis is a common chronic recurrent inflammatory skin disorder characterized by hyperproliferation and reduced differentiation of keratinocytes. It is a life long chronic inflammatory condition affecting approximately 2% of general population.1 The etiology is still unknown, while genetic, metabolic and immunological mechanism has been implicated. Psoriasis has been associated with an increased morbidity and mortality from high frequency of cardiovascular events. This seems to be related to the severity of psoriasis, considering that it occurs much more frequently in patients presenting with large areas of body affected with psoriatic lesions. However, the pathogenesis of atherothrombotic events in psoriasis patients remains to be recognized. Multiple factors including abnormal lipids and lipoprotein profiles and risk factors such as hypertension, obesity, diabetes mellitus have been associated with psoriasis.3 Several reports suggests that psoriatic patients have proatherogenic lipid profile including increased levels of serum triglycerides, LDL-cholesterol, VLDL-cholesterol and low HDL-cholesterol levels. However, studies are ABSTRACT Background: Psoriasis is a common and recurrent proliferative inflammatory skin disease that has been associated with abnormal plasma lipid metabolism and with high frequency of cardiovascular morbidity and mortality. The prevalence seems to be related to the severity of psoriasis, as it occurs more frequently in patients presenting with large areas of the body affected with lesions. The aim of our work was to evaluate the development of dyslipidemia in psoriasis, and to look for a correlation between their levels and severity of diseases in which the risk factors and secondary causes of hyperlipidemia were excluded. Methods: We evaluated the fasting lipid profile in twenty-four patients with mild to moderate psoriasis and twentyfour age and gender matched healthy subjects as the control group. Results: Patients presented risk changes in lipid profile, serum total cholesterol (p<0.001), triglyceride (p<0.01), LDL-cholesterol (p<0.001), VLDL-cholesterol (p<0.01) and TC/HDL ratio (p<0.01) were found to be significantly higher than in control group. No significant statistical difference was observed between HDL levels of the two groups. Significant positive correlation in total cholesterol and LDL-cholesterol was found between mild and moderate psoriasis (PASI score) as compared with controls. Conclusion: Our data suggest that psoriasis patients must be considered as a group at high risk for cardiovascular, since psoriasis per se seems to be associated with risk changes in the lipid profile. We conclude that psoriatic patients should be evaluated and followed up for the risk of hyperlipidemia and cardiovascular diseases.

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“…The raise observed in the present studies, in psoriasis patients, in plasma lipid profile parameters, specifically, the TC and the TAG is in agreement with earlier workers. [6][7][8]10,11,[14][15][16][17][18][32][33][34][35] The raised plasma levels of lipid parameters in psoriasis may be due to psoriasis-induced inflammation which leads to an increased systemic synthesis of lipids, cholesterol and triacylglycerols because of inflammatory triggered production of cell signalling compounds including the cytokins and the other factors which tends to stimulate the systemic lipid synthesis by inducing Sterol Response Element Binding Protein (SREBP) genes as well as by inducing the genes responsible for HMG CoA reductase enzyme production there by enhancing lipid and cholesterol synthesis, which is essential for the supply of extra lipids and other lipid parameters required for the psoriatic plaque formation. 36,37 The various lipid transporting protein and related apoproteins synthesis may also boosted in order to transport these lipid components.…”

Section: Discussionmentioning

confidence: 99%

Inter relationship of plasma lipid profile parameters with plasma uric acid levels in psoriasis

2018

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Background: Psoriasis is a chronic immune mediated skin disease accompanied with disturbances in systemic lipid turnover. Hyperuricemia has been frequently observed as an additional complication in psoriasis. The relationship between the raised plasma lipid parameters and the uric acid levels in psoriasis need to be ascertained. A study was undertaken to assess the possible relationship of plasma lipid parameters with plasma uric acid levels in psoriasis and to relate any such relationship to psoriasis disease severity.Methods: Non arthritic psoriasis patients were randomly selected and were grouped into mild (Group 1), moderate (Group 2) as well as severe (Group 3) based on their PASI scores. Plasma lipid parameters and uric acid levels were assessed in these patients.Results: The results show a significant (p<0.001) parallel raise in plasma uric acid levels along with plasma lipid parameters with the severity of disease in these patients.Conclusions: A plasma uric acid level along with plasma total cholesterol and triacylglycerol levels fetch much information on the severity of psoriasis disease.

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The significance of autoantibodies against oxidatively modified low-density lipoprotein (LDL) in patients with psoriasis

Cited by 36 publications

References 24 publications

Are Anti–Oxidized Low-Density Lipoprotein Antibodies Pathogenic or Protective?

Are Anti–Oxidized Low-Density Lipoprotein Antibodies Pathogenic or Protective?

Dyslipidemia in psoriasis: as a risk for cardiovascular disease

Inter relationship of plasma lipid profile parameters with plasma uric acid levels in psoriasis

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