1957
DOI: 10.1093/ajcp/28.5.469
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The Significance of Blood Group Conflicts and Aberrant Salivary Secretion in Spontaneous Abortion

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Cited by 17 publications
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“…Saliva group inhibiton studies of Ax, A2, B and H were performed as previously described [7]. Emphasis was placed upon the accurate detection of At and A2 secretion ability and for this test a constant source of A2 and A2 cells was used and a preliminary titration of the anti-A serum was made to select the proper dilution to be used with each cell.…”
Section: Case Materials and Methodsmentioning
confidence: 99%
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“…Saliva group inhibiton studies of Ax, A2, B and H were performed as previously described [7]. Emphasis was placed upon the accurate detection of At and A2 secretion ability and for this test a constant source of A2 and A2 cells was used and a preliminary titration of the anti-A serum was made to select the proper dilution to be used with each cell.…”
Section: Case Materials and Methodsmentioning
confidence: 99%
“…Thus, a group A individual who secretes will inhibit anti-A serum. Group AB persons would therefore possess both substances and presumably their salivas would inhibit both anti-A and anti-B serums to approximately an equal titer.Our study of blood group secretion patterns in control families and those who have had several abortions [7] has led us to a critical quantitative analysis of those who belong to blood groups A2 and A2B. The results of these tests have varied widely with the expected behavior of secretion of A substance, while the B substance has exhibited a much greater stability.…”
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confidence: 99%
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“…This finding would appear to confer some advantage upon the secretor fetuses in heterospecific pregnancies. McNeil et al [1957] found that among couples in which the wife had suffered two or more spontaneous abortions: (a) immune antibodies in the ABO system were usually present in the wife; (b) mother, father, or both were generally aber rant secretors (defined as persons of group A or B who secrete only one blood group factor rather than the expected two) ; (c) the matings were generally incompatible in the ABO system ; (d) mothers in the aborter group tended to be, if not aberrant secretors, then weak secretors or nonsecretors. F reda [1958] pointed out th at the in compatible nonsecretor fetus of a m other with immune ABO anti bodies would have less protection against these m aternal antibodies.…”
mentioning
confidence: 99%