“…Modern 3D computer-assisted surgery (3D CAS), which combines 3D printing technology with 3D imaging techniques, has undergone remarkable developments in the past decades. As shown in Figure 2 , several protocols are essential to 3D CAS: 1) information acquisition, 2) planning, 3) virtual operation, 4) 3D printing, and 5) surgery and postoperative analysis ( Troulis et al, 2002 ; Prevost et al, 2019 ; Mian et al, 2022 ). Although potential errors occur in the fabrication of customized barrier membranes after tomography data acquisition, image processing, and 3D fabrication ( Tian et al, 2021 ), technological developments in rapid prototyping systems have considerably contributed to the accurate and detailed replication of craniofacial devices ( Sharma et al, 2021 ).…”