The Significance of Electrocardiographic Changes Produced by Thioridazine

Wendkos, Martin H.

doi:10.1002/j.1552-4604.1964.tb00210.x

Cited by 28 publications

(5 citation statements)

References 6 publications

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“…Moreover, thioridazine appears to have a relatively greater effect on QTc than most other antipsychotics, both in clinical use (43) and in overdose (54). Other cardiac effects associated with thioridazine include T‐wave changes (55), which are plasma level‐dependent (56), and U‐wave formation (57). Both phenomena suggest a drug‐induced effect on repolarization.…”

Section: Qt Changes and Antipsychoticsmentioning

confidence: 99%

Antipsychotics and QT prolongation

Taylor

2003

Acta Psychiatr Scand

146

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Available data do not allow assessment of relative or absolute risk of dysrhythmia or sudden death engendered by antipsychotics but caution is advised. Risk of dysrhythmia can very probably be reduced by careful prescribing of antipsychotics in low doses in simple drug regimens which avoid metabolic interactions. Electrocardiographic monitoring may also help to reduce risk but review by specialist cardiologist may be necessary.

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Section: Qt Changes and Antipsychoticsmentioning

confidence: 99%

Antipsychotics and QT prolongation

Taylor

2003

Acta Psychiatr Scand

146

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“…Comment E.C.G. changes reported in patients taking more than 200 mg of thioridazine daily include abnormal Q-T intervals, U waves, and T wave changes (Kelly, et al, 1963;Wendkoss, 1964;Huston and Bell, 1966;Alexander, et al, 1967). Fatal ventricular fibrillation has occurred in patients taking over 2 g of the drug daily (Giles and Modlin, 1968;Shoonmaker et al, 1966).…”

Section: Casementioning

confidence: 99%

Epidermal necrolysis from clothing impregnated with paraffin.

Barnes¹,

Wilkinson²

1973

BMJ

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Toxic epidermal necrolysis was first described by Lyell (1956) in Great Britain and Lang and Walker (1956) in South Africa. The explosive nature of the eruption, which often occurs in young subjects, and the characteristic "sliding away" of the epidermis over a red and sharply demarcated base usually allow easy recognition.In a review of 128 cases Lyell (1967) found staphylococci (particularly of phage type 71) and drugs responsible for just over half the cases in children under 10 years of age. Drugs were responsible for most cases in early adult life. In his "miscellaneous" group-occurring at all ages-he mentioned "poisons" as a cause in five cases. One of these was due to externally encountered paraffin (kerosene) in an epileptic. The following case history draws attention to this cause of an acute necrolytic eruption which may occur more often than is apparent from the sparse records. Case HistoryA 12-year-old boy was brought to the casualty department of Wycombe General Hospital on a Sunday morning in February 1972, having developed a rash of rather startling appearance on the second day of a camping weekend. The eruption was characteristically that of toxic epidermal necrolysis and he was admitted to the dermatology ward. On examination he was found to be a cheerful and obviously healthy boy. Temperature and pulse rate were normal and his only complaint was of pain, discomfort, and limitation of movement associated with the eruption. This consisted of an extensive area of intensely erythematous skin over which the epidermis had either become detached or could be detached by slight movement of the fingers. At the lower level of epidermal loosening there was a collection of apparently purulent fluid. The eruption, involving an area of about 150 cm2, extended upwards on each side of the chest to include the axillary folds and the inner aspects of the upper arms as far as the antecubital fossae. The axillary apices were spared. Two smaller patches were present on the front of the neck. There were no mucosal lesions and the rest of the skin was clear. Progress was uneventful with bland treatment and he was discharged a week later. A nasal swab grew Staphylococcus aureus, phage type 55. Swabs from the throat and the purulent skin sac were sterile.On the day after admission a fuller history was obtained from his parents who confirmed the absence of any preceding illness, medicines, or drugs. The boy had left for a weekend camping expedition with other members of a club on the Friday night. The clothes he carried in his knapsack had been packed in a polyethylene bag, separate from other camping equipment, which included a plastic one-litre bottle containing paraffin (kerosene). The first day passed without incident and the boy noticed the rash only on waking on the Sunday morning. He had slept in pyjamas over which he wore a heavy sweater, the weather being somewhat cold. It is probable that he had not replaced his clothes in the polyethylene bag on the Saturday morning and it is certain that they came in contac...

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“…3). This observation was particularly significant since earlier studies had demonstrated that these 3 substances were unable to abolish the T‐wave abnormalities characteristic of abnormal ventricular repolarization due to cardiac pathology or quinidine therapy (5). The procedures adopted in connection with the use of these 3 compounds were simple and the results could be determined within twenty to ninety minutes, depending upon the agent being employed.…”

Section: Benign Myocardial Aberration In Thioridazine‐treated Subjectsmentioning

confidence: 99%

“…The procedures adopted in connection with the use of these 3 compounds were simple and the results could be determined within twenty to ninety minutes, depending upon the agent being employed. The technical details of the method have already been described elsewhere (5, 6).…”

Section: Benign Myocardial Aberration In Thioridazine‐treated Subjectsmentioning

confidence: 99%

The Significance of Electrocardiographic Changes Produced by Thioridazine

Cited by 28 publications

References 6 publications

Antipsychotics and QT prolongation

Antipsychotics and QT prolongation

Epidermal necrolysis from clothing impregnated with paraffin.

Cardiac Changes Related to Phenothiazine Therapy, With Special Reference to Thioridazine*

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