The Significance of Fever in Neoplastic Disease

Browder, Ann A.

doi:10.7326/0003-4819-55-6-932

Cited by 66 publications

(24 citation statements)

References 19 publications

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“…Neoplastic fever, which is defined as fever caused by cancer itself, has been shown to be the most common cause of fever of unknown origin in cancer patients, particularly lymphoma and leukemia patients (13,14,17). Neoplastic fever is relatively rare in patients with bone and soft tissue sarcomas, with only few cases reported to date (18)(19)(20)22).…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, neoplastic fever occurred in 11 of 195 patients with bone and soft tissue sarcomas (5.5%). Browder et al (17) reported that 30% of cancer patients develop fever, and that in 5% of the patients, the fever has no explanation other than paraneoplastic syndrome. Thus, neoplastic fever should be considered when all other possible causes of fever are excluded.…”

Section: Discussionmentioning

confidence: 99%

“…If all the potential causes of fever are excluded, the possibility of neoplastic fever should be considered (13,15,16). Neoplastic fever is a paraneoplastic syndrome that is encountered in 5% of cancer patients (17). There have been a few case reports on neoplastic fever among patients with bone and soft tissue sarcomas (18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

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Neoplastic fever in patients with bone and soft tissue sarcoma

Nakamura

Matsumine

Matsubara

et al. 2016

Molecular and Clinical Oncology

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Abstract. The development of fever is a common complication in the clinical course of cancer. If all other potential causes of fever are excluded, the possibility of neoplastic fever should be considered. The aim of the present study was to determine the incidence of neoplastic fever in patients with bone and soft tissue sarcomas. Between January 2009 and December 2014, 195 patients with bone and soft tissue sarcoma (111 men and 84 women; mean age, 55 years) were admitted to

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Neoplastic fever in patients with bone and soft tissue sarcoma

Nakamura

Matsumine

Matsubara

et al. 2016

Molecular and Clinical Oncology

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“…9,10 In NNCPs, fever of unknown origin is a challenging diagnosis; malignant tumors can be a source of fever in the absence of infection, particularly in patients with lymphoma and solid tumors with liver metastasis. 11 These patients are commonly exposed to unnecessary antibiotics, with the accompanying risks of toxicity, bacterial resistance, increased medical costs, and delays in the administration of systemic chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Can procalcitonin distinguish infectious fever from tumor‐related fever in non‐neutropenic cancer patients?

Shomali

Hachem

Chaftari

et al. 2012

Cancer

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BACKGROUND: Procalcitonin (PCT) has been proposed as a marker of infection and was studied in neutropenic patients. This study investigated its role in non‐neutropenic febrile cancer patients (NNCPs). METHODS: Between July 2009 and July 2010, a total of 248 NNCPs with fever were studied. PCT was measured in plasma within 24 hours of fever onset and 4 to 7 days thereafter, using a Kryptor system with a lower limit of quantitation of 0.075 ng/mL. Patients' clinical, microbiological, and radiological data were reviewed to make the diagnosis and were correlated with PCT levels. RESULTS: This study included 30 patients with bloodstream infection (BSI), 60 with localized bacterial infection, 141 with no documented infection, and 8 with tumor‐related fever. Most patients (98%) were inpatients or admitted to the hospital during the study. Patients with BSI had significantly higher PCT levels than did those with documented localized infections (P = .048) and no documented infection (P = .011). PCT levels were significantly higher in septic patients than in those without sepsis (P = .012). Patients with stage IV disease or metastasis had significantly higher baseline PCT levels than did those with early stages of cancer (P < .05). PCT levels dropped significantly in patients with bacterial infections in response to antibiotics (P < .0001). CONCLUSIONS: Baseline PCT levels are predictive of BSI and sepsis in NNCPs. They may be predictors of metastasis and advanced cancer. Subsequent decrease in PCT levels in response to antibiotics is suggestive of bacterial infection. Larger trials are needed to confirm the results of this pilot study. Cancer 2012. © 2012 American Cancer Society.

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“…4 Follow-up data of larger groups of cancer patients has supported that the naproxen test has a high degree of sensitivity and specifi city, with a high positive predictive value. 5,6 Particularly when clinical suspicion is high, this may provide an effective aid in differentiating neoplastic from infectious fever in cancer patients in whom naproxen is not contraindicated (see Box 1).…”

Section: Naproxen Testmentioning

confidence: 99%

Malignant causes of fever of unknown origin

Foggo

Cavenagh

2015

Clinical Medicine

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The presence of fever in malignancy usually indicates infection, though transfusion, thrombosis and drugs are also culprits. However, particularly in some tumour types, fever can also be a paraneoplastic syndrome, caused by the malignancy itself. This can be a diffi cult diagnosis to establish and presents a therapeutic challenge to the physician when the underlying malignancy is not easily treated.

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The Significance of Fever in Neoplastic Disease

Cited by 66 publications

References 19 publications

Neoplastic fever in patients with bone and soft tissue sarcoma

Neoplastic fever in patients with bone and soft tissue sarcoma

Can procalcitonin distinguish infectious fever from tumor‐related fever in non‐neutropenic cancer patients?

Malignant causes of fever of unknown origin

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