The significance of fibrinolysis occurring in patients with metastatic cancer of the prostate

Tagnon, Henri; Whitmore, Willet F.; Schulman, Phyllis; Kravitz, Sheldon C.

doi:10.1002/1097-0142(195301)6:1<63::aid-cncr2820060105>3.0.co;2-l

Cited by 113 publications

(16 citation statements)

References 5 publications

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“…5 Clinical signs of DIC are noted in only 0.4%-1.65% of patients with prostate cancer, including a bleeding tendency. 6 In these patients, DIC can be triggered by surgical procedures like prostate biopsy causing hemorrhage in multiple sites, such as the skin, genitourinary organs, gastrointestinal tracts and submit your manuscript | www.dovepress.com…”

Section: Discussionmentioning

confidence: 99%

Acute renal failure as the presenting sign of disseminated intravascular coagulation in a patient with metastatic prostate cancer

Ohashi¹,

Hosokawa²,

Kimura³

et al. 2013

IJNRD

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Disseminated intravascular coagulation (DIC) is the most frequent coagulation disorder in patients with prostate cancer. However, renal involvement in DIC associated with prostate cancer has rarely been documented. Herein, we present a case of metastatic prostate cancer presenting with acute renal failure (RF) triggered by DIC. An 80 year old man with metastatic prostate cancer was treated with antihormone therapy at an outpatient clinic. He was admitted to our hospital because of severe dyspnea and progressive RF. A hemorrhagic tendency was not clinically evident. Laboratory tests exhibited a significant coagulation disorder, suggestive of DIC. Despite treatment, his RF and dyspnea worsened, and he eventually passed away. An autopsy study revealed hypertensive nephrosclerosis superimposed by fibrin rich thrombi formation involving glomerular capillaries and arterioles characteristic of DIC. Additionally, focal segmental glomerulosclerosis was identified, which was presumably secondary to the glomerular endothelial and/or podocyte injury augmented by DIC. Those findings showed that glomerular injury, which was induced and subsequently exacerbated by DIC associated with prostate cancer, highly contributed to the progression of RF in our case. A differential diagnosis of DIC should be considered when a patient with prostate cancer presents with renal dysfunction.

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Section: Discussionmentioning

confidence: 99%

Acute renal failure as the presenting sign of disseminated intravascular coagulation in a patient with metastatic prostate cancer

Ohashi¹,

Hosokawa²,

Kimura³

et al. 2013

IJNRD

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show abstract

“…Prostate cancer patients are known to possess an increased risk for both thromboembolic and bleeding events, probably due to activation of the fibrinolytic system [13]. Surgical trauma as such activates coagulation, and antithrombotic therapy to prevent VTE after surgery is thus generally recommended [14].…”

Section: Discussionmentioning

confidence: 99%

Dabigatran for thromboprophylaxis after robotic assisted laparoscopic prostatectomy: Retrospective analysis of safety profile and effect on blood coagulation

Säily

Pétas

Joutsi‐Korhonen

et al. 2013

Scandinavian Journal of Urology

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“…1 There are reports of bacterial growth from explanted orbital implants. [2][3][4][5] Organisms include Gram-positive and -negative bacteria and atypical mycobacteria. 2,4 Growth of Eikenella corrodens from orbital hardware has not been reported.…”

Section: Discussionmentioning

confidence: 99%

“…[2][3][4][5] Organisms include Gram-positive and -negative bacteria and atypical mycobacteria. 2,4 Growth of Eikenella corrodens from orbital hardware has not been reported. This comensual facultative anaerobic gram-negative bacillus is typically found in oral, respiratory, gastrointestinal, and genitourinary flora.…”

Section: Discussionmentioning

confidence: 99%

Conjunctival Bleeding After Ectropion Repair Due to Paraneoplastic Primary Fibrinolysis

Pasquali

Mehta²,

Perry³

2012

Ophthalmic Plastic &Amp; Reconstructive Surgery

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In addition to predisposing a patient to hypercoaguability and thrombosis, cancers may also cause an antithetical bleeding diathesis through primary fibrinolysis. This paraneoplastic pathology has been documented and studied in prostate cancer patients for nearly a century but is under-recognized as a possible complication of surgery. We report a case of primary fibrinolysis after elective ectropion repair in a patient with prostate cancer. Here paraneoplastic fibrinolysis produced a delayed postoperative hemorrhage requiring specialized therapies, including hospitalization for transfusions of fresh frozen plasma and inhibitors of fibrinolysis. Even in the case of an ambulatory and stable cancer patient, awareness of this complication and its management can help guide surgical decision-making and improve outcomes and follow-up care.

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The significance of fibrinolysis occurring in patients with metastatic cancer of the prostate

Cited by 113 publications

References 5 publications

Acute renal failure as the presenting sign of disseminated intravascular coagulation in a patient with metastatic prostate cancer

Acute renal failure as the presenting sign of disseminated intravascular coagulation in a patient with metastatic prostate cancer

Dabigatran for thromboprophylaxis after robotic assisted laparoscopic prostatectomy: Retrospective analysis of safety profile and effect on blood coagulation

Conjunctival Bleeding After Ectropion Repair Due to Paraneoplastic Primary Fibrinolysis

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