The significance of gemistocytes in astrocytoma

Yang, Hui; Kim, J. E.; Paek, So Hyun; G., Je; Kim, D. G.

doi:10.1007/s00701-003-0149-4

Cited by 19 publications

(19 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Interestingly, the strongest correlation between the expression of ρ2 and θ subunits was found in gemistocytic astrocytomas. The presence of gemistocytes in a tumor has been correlated with worse prognosis [31], [32], although the proportion of gemistocytes in the tumor does not seem to have an effect [32]. The reasons for development of gemistocytes in tumors are still poorly understood, but it has been suggested that they may develop due to losing the competition for substrates with adjacent cells [31], [32].…”

Section: Discussionmentioning

confidence: 99%

GABA-A Channel Subunit Expression in Human Glioma Correlates with Tumor Histology and Clinical Outcome

et al. 2012

View full text Add to dashboard Cite

GABA (γ-aminobutyric acid) is the main inhibitory neurotransmitter in the CNS and is present in high concentrations in presynaptic terminals of neuronal cells. More recently, GABA has been ascribed a more widespread role in the control of cell proliferation during development where low concentrations of extrasynaptic GABA induce a tonic activation of GABA receptors. The GABA-A receptor consists of a ligand-gated chloride channel, formed by five subunits that are selected from 19 different subunit isoforms. The functional and pharmacological properties of the GABA-A channels are dictated by their subunit composition. Here we used qRT-PCR to compare mRNA levels of all 19 GABA-A channel subunits in samples of human glioma (n = 29) and peri-tumoral tissue (n = 5). All subunits except the ρ1 and ρ3 subunit were consistently detected. Lowest mRNA levels were found in glioblastoma compared to gliomas of lower malignancy, except for the θ subunit. The expression and cellular distribution of the α1, γ1, ρ2 and θ subunit proteins was investigated by immunohistochemistry on tissue microarrays containing 87 gliomas grade II. We found a strong co-expression of ρ2 and θ subunits in both astrocytomas (r = 0.86, p<0.0001) and oligodendroglial tumors (r = 0.66, p<0.0001). Kaplan-Meier analysis and Cox proportional hazards modeling to estimate the impact of GABA-A channel subunit expression on survival identified the ρ2 subunit (p = 0.043) but not the θ subunit (p = 0.64) as an independent predictor of improved survival in astrocytomas, together with established prognostic factors. Our data give support for the presence of distinct GABA-A channel subtypes in gliomas and provide the first link between specific composition of the A-channel and patient survival.

show abstract

Section: Discussionmentioning

confidence: 99%

GABA-A Channel Subunit Expression in Human Glioma Correlates with Tumor Histology and Clinical Outcome

et al. 2012

View full text Add to dashboard Cite

show abstract

“…This retrospective case series is, to the best of our knowledge, the largest and first dedicated attempt to document the MR imaging features of this tumour. While imaging features have been touched upon in other papers, the literature is limited to either case reports or clinico‐pathological papers where only some imaging features are discussed …”

Section: Discussionmentioning

confidence: 99%

“…While there have been several studies analysing histopathological features of these tumours, there is a paucity of literature on the radiological appearance . What literature is available is limited to single case reports and one clinico‐pathologically focused study that briefly describes only some imaging findings . These publications, as well as anecdotal experience, suggest that gemistocytic astrocytomas have significantly different imaging features to the more common diffuse fibrillary astrocytomas.…”

Section: Introductionmentioning

confidence: 99%

Magnetic resonance imaging features of gemistocytic astrocytoma

et al. 2016

View full text Add to dashboard Cite

Introduction: Gemistocytic astrocytoma is the second most common subtype of World Health Organization grade 2 astrocytoma, but has a worse prognosis than other grade 2 lesions. We aim to describe the MR imaging features of histopathologically proven gemistocytic tumours. Methods: Ethics approval was obtained from both institutions. Patient consent was not required for this retrospective study. We reviewed MR imaging findings of 16 consecutive cases of histopathologically proven gemistocytic astrocytoma and anaplastic astrocytoma with gemistocytic features. Results: Average patient age was 48 years, with a 3:1 male to female ratio. Based on our series, the typical appearance of a gemistocytic astrocytoma is a large, heterogeneous mass most commonly supratentorial and lobar. Regions of cyst formation, partial signal suppression on FLAIR images and contrast enhancement are all common features. Additionally, contrary to previous literature that describes gemistocytic astrocytoma as a purely supratentorial lesion, we present two cases of gemistocytic astrocytoma involving the brainstem. Conclusions:The possibility of gemistocytic astrocytoma should be considered in patients presenting with large heterogeneous tumours that have regions of cyst formation, partial FLAIR suppression and contrast enhancement. This may be especially useful in reconciling a lesion with high-grade MR imaging features with low-grade histopathology. An infratentorial location does not preclude the diagnosis of gemistocytic astrocytoma.

show abstract

“…Diversos autores consideram esses elementos celulares conseqüentes a alterações regressivas (indiferenciação) e sugerem sua correlação com pior prognóstico clínico (14,24) . Já os gemistócitos foram encontrados desde os astrocitomas de baixo grau (I e II), todavia com maior representação entre os tumores de alto grau, assim como relatado na literatura (28) . Esses componentes celulares, por sua vez, são descritos como possivelmente resultantes da degeneração de astrócitos neoplásicos, conquanto sua origem permaneça incerta (7,18) .…”

Section: Necroseunclassified

“…Tumores astrocíticos de baixo grau, em que são demonstrados gemistócitos, exibem tendência à rápida progressão para subtipos mais malignos. Apesar disso, não se constata correlação direta entre a proporção de gemistócitos e o prognóstico dos pacientes (28) .…”

Section: Necroseunclassified

Estratégias auxiliares para graduação dos tumores astrocíticos segundo os critérios histopatológicos estabelecidos pela OMS

Faria¹,

Patrocínio

Rabenhorst³

2006

J. Bras. Patol. Med. Lab.

View full text Add to dashboard Cite

Introdução: Apesar das recentes descobertas acerca das alterações moleculares envolvidas na tumorigênese dos astrocitomas, a análise histológica convencional permanece o melhor método diagnóstico e razoável indicador prognóstico dos tumores astrocíticos. Todavia, a rotina histopatológica preconizada pela Organização Mundial da Saúde (OMS) mostra-se laboriosa, sendo marcada pela baixa reprodutibilidade. Objetivo: O presente estudo objetivou desenvolver estratégias auxiliares para graduação dos tumores astrocíticos a partir dos critérios histológicos estabelecidos pela OMS. Material e método: Procedeu-se à análise clínico-epidemiológica e à reavaliação histopatológica de 55 astrocitomas de diferentes gradações (13 grau I, 14 grau II, sete grau III e 21 grau IV) e de cinco amostras de tecido cerebral não-tumoral (grupo controle). Resultados: A distribuição por idade, por sexo e pela localização tumoral dos portadores dessas neoplasias reproduziu, de um modo geral, as tendências mundiais. A presença de células gigantes multinucleadas e de gemistócitos foi associada à malignidade tumoral. Os achados histopatológicos avaliados segundo critérios semiquantitativos e pelo modelo de aprendizagem CART confirmaram a gradação original, reiterando a aplicabilidade e a reprodutibilidade dos mesmos. Conclusão: Tais resultados indicaram a árvore de decisão CART e o somatório de escores semiquantitativos como estratégias práticas e auxiliares para a graduação dos astrocitomas segundo os critérios da OMS. Astrocitomas

show abstract

The significance of gemistocytes in astrocytoma

Abstract: It is suggested that the proportion of gemistocytes does not itself affect prognosis.

Cited by 19 publications

References 25 publications

GABA-A Channel Subunit Expression in Human Glioma Correlates with Tumor Histology and Clinical Outcome

GABA-A Channel Subunit Expression in Human Glioma Correlates with Tumor Histology and Clinical Outcome

Magnetic resonance imaging features of gemistocytic astrocytoma

Estratégias auxiliares para graduação dos tumores astrocíticos segundo os critérios histopatológicos estabelecidos pela OMS

Contact Info

Product

Resources

About