The significance of giant cells in human testicular seminomas

Hochstetter, A. R. von; Sigg, C; Saremaslani, Parvin; Hedinger, Chr.

doi:10.1007/bf00710656

Cited by 50 publications

(21 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some investigators have observed the same good results as for HCG-negative seminomas [10, 14, 16, 18, 19, 26, 27, 28], while others stated a poorer outcome [6, 7, 17, 29, 30, 31, 32]. Nearly all reports were based on small, retrospectively documented series.…”

Section: Discussionmentioning

confidence: 89%

See 1 more Smart Citation

Prognostic Factors in Seminomas with Special Respect to HCG: Results of a Prospective Multicenter Study

et al. 1999

View full text Add to dashboard Cite

Objective: In a prospective multicenter trial, it was our intention to elucidate clinical prognostic factors of seminomas with special reference to the importance of human chorionic gonadotropin (HCG) elevations in histologically pure seminomas. Methods: Together with 96 participating urological departments in Germany, Austria, and Switzerland, we recruited 803 seminoma patients between 1986 and 1991. Out of 726 evaluable cases, 378 had elevated, while 348 had normal HCG values in the cubital vein. Histology was reviewed by two reference pathologists. HCG levels were determined in local laboratories and in a study laboratory. Standard therapy was defined as radiotherapy in stages I (30 Gy) and IIA/B (36 Gy) to the paraaortal and the ispilateral (stage I) and bilateral (stage IIA/B) iliac lymph nodes; higher stages received polychemotherapy and surgery in case of residual tumor masses. Statistics included chi-square tests, linear Cox regression, and log-rank test. Results: The HCG elevation is associated with a larger tumor mass (primary tumor and/or metastases). HCG-positive and HCG-negative seminomas had no different prognostic outcome after standard therapy. The overall relapse rate of 6% and the survival rate of 98% after 36 months (median) indicate an excellent prognosis. The calculation of the relative risk of developing a relapse discovered only stage of the disease and elevation of the lactate dehydrogenase concentration and its prolonged marker decay as independent prognostic factors for seminomas. A more detailed analysis of the prognostic significance of the stage revealed that the high relapse rate in stage IIB seminomas after radiotherapy (24%) is responsible for this result. Conclusions: We conclude that HCG-positive seminomas do not represent a special entity. Provided standard therapy is applied, HCG has no influence on the prognosis. Patients with stage IIB disease should be treated with chemotherapy because of the demonstrated higher relapse rate outside the retroperitoneum.

show abstract

Section: Discussionmentioning

confidence: 89%

“…The supposed poor prognosis of HCG-positive seminomas was supported [6, 7, 8, 9]or refuted [10, 11, 12, 13, 14, 15, 16, 17, 18, 19]by reports on small series. It was discussed, whether it represented an intermediate form between seminomas and nonseminomas [20].…”

Section: Introductionmentioning

confidence: 99%

Prognostic Factors in Seminomas with Special Respect to HCG: Results of a Prospective Multicenter Study

et al. 1999

View full text Add to dashboard Cite

show abstract

“…About 5% of germinomas have distinct admixed syncytiotrophoblast cells, 73,83 although additional cases with inconspicuous syncytiotrophoblast cells can be identified using immunohistochemical stains for human chorionic gonadotropin (hCG). 84 When these cells are widely dispersed, as is typically the case, this phenomenon does not usually create diagnostic confusion. However, when they occur in sizable clusters, there may be concern for choriocarcinoma ( Figure 15).…”

Section: Germinomamentioning

confidence: 99%

Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues

2005

View full text Add to dashboard Cite

“…The appearance of STGCs in human trophoblastic or choriocarcinomatous germ cell tumor is known to be associated with metastasis and poor prognosis (40). Therefore, Parp deficiency could confer more malignant phenotype in germ cell tumor as a consequence.…”

Section: Presence Of Stgcs and Extensive Hemorrhage In Tumors Derivedmentioning

confidence: 99%

Syncytiotrophoblastic giant cells in teratocarcinoma-like tumors derived from Parp -disrupted mouse embryonic stem cells

Nozaki

Masutani

Watanabe

et al. 1999

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

P oly(ADP-ribose) polymerase (Parp) catalyzes the poly(ADPribosyl)ation reaction of Parp itself and other nuclear proteins by using NAD as a substrate after activation by single-or double-strand breaks of DNA. Recent studies using Parp knockout mice and cells showed that Parp is involved in recovery from DNA damages and maintenance of genomic integrity (1-7). On the other hand, because poly(ADP-ribosyl)ation of nuclear proteins causes the accumulation of negative charges and conformational changes on acceptor proteins, it is suggested that poly(ADP-ribosyl)ation of proteins could affect the local chromosome organization and consequently alter various gene expressions. In fact, studies have indicated that Parp is involved in transcriptional regulation of genes (8-10) and cellular differentiation processes (11)(12)(13)(14). Poly(ADP-ribose) synthesis dramatically decreases in teratocarcinoma EC-A1 cells during in vitro differentiation induced by retinoic acid (11). Furthermore, the teratocarcinoma cells undergo differentiation in vitro in the presence of the Parp inhibitor, 3-aminobenzamide (11). A potent Parp inhibitor, 5-iodo-6-amino-1,2-benzopyron, also induces the phenotypic reversions of tumorigenic endothelial cells transformed with H-ras and of prostate carcinoma cells (14). This evidence thus suggests that Parp could be involved in tumorigenesis through affecting cellular differentiation. However, be- Materials and MethodsCells and Culture Condition. The wild-type J1 as well as Parpdeficient ES cells were cultured as described (21). Briefly, cells were maintained in a humidified incubator at 37°C under 5%Abbreviations: Parp, poly(ADP-ribose) polymerase; ES, embryonic stem; STGCs, syncytiotrophoblastic giant cells. † To whom reprint requests should be addressed.

show abstract

The significance of giant cells in human testicular seminomas

Cited by 50 publications

References 15 publications

Prognostic Factors in Seminomas with Special Respect to HCG: Results of a Prospective Multicenter Study

Prognostic Factors in Seminomas with Special Respect to HCG: Results of a Prospective Multicenter Study

Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues

Syncytiotrophoblastic giant cells in teratocarcinoma-like tumors derived from Parp -disrupted mouse embryonic stem cells

Contact Info

Product

Resources

About