The significance of glypican‐3 expression profiling in the tumor cellular origin theoretical system for hepatocellular carcinoma progression

Xue, Ran; Ji-liang, Feng; Meng, Qingying; Lv, Fang; Zhu, Yueyong; Yu, Hongwei; Zhang, Shijie; Chen-zhao, Song; Sun, Lin; Yue, Zhujun; Feng, Shuai; Che, Ruiwen; Xiang, Qian; Jing, Xuefang

doi:10.1111/jgh.13736

Cited by 24 publications

(27 citation statements)

References 34 publications

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“…1 ). [ 18 – 22 , 26 – 31 , 33 – 35 ] Among the 14 articles, 7 literature were based on China, [ 18 , 21 , 28 – 30 , 33 , 35 ] 4 performed in Japan, [ 19 , 20 , 22 , 26 ] 1 in Taiwan, [ 31 ] 1 in Korea, [ 27 ] and 1 in USA. [ 34 ] All articles used the method of IHC to detect GPC3 expression in tissues.…”

Section: Resultsmentioning

confidence: 99%

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Overexpression of glypican-3 is a predictor of poor prognosis in hepatocellular carcinoma

Zhang

et al. 2018

Medicine

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Background:Glypican-3 (GPC3) has been widely recognized in the progression of liver tumors for several years. The relationship between overexpression of GPC3 and the poorer prognosis of patients with hepatocellular carcinoma (HCC) was performed by 2 meta-analyses. However, there were also some latest literatures that indicated different conclusions distinctly. It is necessary for us to carry out a meta-analysis by adding the latest data from current studies to explore the correlation between GPC3 and prognostic value in HCC.Methods:We conducted a meta-analysis including a total of 14 studies to assess the potential prognostic significance of GPC3 expression for overall survival (OS) and disease-free survival (DFS). The expression of GPC3 was assessed by immunohistochemistry.Results:Fourteen studies with 2364 patients were incorporated in the meta-analysis. The combined hazard ratios (HRs) revealed that the overexpression of GPC3 could forecast a poor OS [n = 2233 in 12 studies, HR = 1.40, 95% confidence interval (95% CI): 1.07–1.85, Z = 2.42, P = .02] and DFS (n = 1308 in 10 studies, HR = 1.61, 95% CI: 1.13–2.30, Z = 2.63, P = .008) in HCC patients. Subgroup treated by hepatectomy indicated that the pooled HR of OS was 1.43 (95% CI: 1.01–2.01, P = .04) and the combined HR of DFS was 1.59 (95% CI: 1.09–2.31, P = .02). The pooled odds ratios (ORs) showed that high GPC3 expression was also extensively associated with worse tumor differentiation, later tumor stage, presence of vascular invasion, and hepatitis B virus (HBV) infection. Subgroup analyses for GPC3 on HCC OS based on the studies categorized by regions, follow-up period, and sample size were also conducted.Conclusion:The meta-analysis indicated that overexpression of GPC3 was significantly associated with poor prognosis in patients with HCC.

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Section: Resultsmentioning

confidence: 99%

“…Twelve studies [ 18 – 22 , 26 – 29 , 33 – 35 ] demonstrated the relevance between GPC3 expression and OS in patients with HCC treated initially by surgical operation resection. Combined analysis from all 9 studies revealed that high GPC3 levels were significantly associated with poorer OS.…”

Section: Resultsmentioning

confidence: 99%

Overexpression of glypican-3 is a predictor of poor prognosis in hepatocellular carcinoma

Zhang

et al. 2018

Medicine

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“…Recently, research into cancer biology has focused on the concept of CSCs. CSCs have the ability to initiate and sustain tumor formation ( O’Brien-Ball and Biddle, 2017 ; Xue et al, 2017a ). CSCs were isolated on the basis of their expression of cell surface markers such as CD44, CD24, and CD133.…”

Section: The Functional Heterogeneity Of Pscsmentioning

confidence: 99%

A Rising Star in Pancreatic Diseases: Pancreatic Stellate Cells

et al. 2018

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Pancreatic stellate cell (PSC) is a type of pluripotent cell located between pancreatic lobules and the surrounding area of acinars. When activated, PSC can be transformed into myofibroblast-like cell. A number of evidences suggest that activated PSC is the main source of the accumulation of extracellular matrix (ECM) protein under the pathological conditions, which lead to pancreatic fibrosis in chronic pancreatitis and pancreatic cancer. Recent studies have found that PSC also plays an important role in the endocrine cell function, islet fibrosis and diabetes. In order to provide new strategies for the treatment of pancreatic diseases, this paper systematically summarizes the recent researches about the biological behaviors of PSC, including its stem/progenitor cell characteristics, secreted exosomes, cellular senescence, epithelial mesenchymal transformation (EMT), energy metabolism and direct mechanical reprogramming.

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“…Routine H&E staining was performed as described previously. 16 The staining results were assessed independently and blindly via two experienced pathologists under light microscope.…”

Section: Haematoxylin-eosin (Hande) Stainingmentioning

confidence: 99%

Mitofusin2, a rising star in acute‐on‐chronic liver failure, triggers macroautophagy via the mTOR signalling pathway

Xue

Zhu

Lin

et al. 2019

J Cellular Molecular Medi

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Acute‐on‐chronic liver failure (ACLF) is a life‐threatening syndrome with poor prognosis. Several studies have begun to prove that mitochondria play a crucial role in liver failure. Mitofusin2 (Mfn2) plays a key role in maintaining the integrity of mitochondrial morphology and function. However, the role and underlying mechanisms of Mfn2 on cell autophagy of ACLF remain unclear. Our aim was to explore the effect of Mfn2 on several biological functions involving cell autophagy in ACLF. In this study, we constructed an ACLF animal model and a hepatocyte autophagy model, using adenovirus and lentivirus to deliver Mfn2 to liver cells, in order to assess the effect of Mfn2 on autophagy and apoptosis in ACLF. Furthermore, we explored the biological mechanism of Mfn2‐induced autophagy of ACLF using Western blotting, RT‐PCR and electron microscopy. We found that Mfn2 significantly attenuated ACLF, characterized by ameliorated gross appearance and microscopic histopathology of liver, and reduced serum AST, ALT, and TBIL levels. Mfn2 improved the expressions of LC3‐II, Atg5 and Bcl‐2 and down‐regulated the expression of P62 and Bax in ACLF. Like rapamycin, Mfn2 also significantly inhibited the expressions of p‐PI3K, p‐Akt and p‐mTOR in ACLF. In conclusion, our findings suggest that Mfn2 influences multiple biological functions of ACLF via the PI3K/Akt/mTOR signalling pathway. This study will provide a reliable theoretical basis for the application of Mfn2 as an effective target for ACLF treatment, reversing or delaying the process of ACLF.

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The significance of glypican‐3 expression profiling in the tumor cellular origin theoretical system for hepatocellular carcinoma progression

Cited by 24 publications

References 34 publications

Overexpression of glypican-3 is a predictor of poor prognosis in hepatocellular carcinoma

Overexpression of glypican-3 is a predictor of poor prognosis in hepatocellular carcinoma

A Rising Star in Pancreatic Diseases: Pancreatic Stellate Cells

Mitofusin2, a rising star in acute‐on‐chronic liver failure, triggers macroautophagy via the mTOR signalling pathway

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