The significance of hair mineral analysis as a means for assessing internal body burdens of environmental pollutants: Results from an IAEA Co-ordinated Research Programme

Toro, E. Cortes; Goeij, J.J.M. de; Bacsó, J.; Cheng, Y.; Kinova, L.; Matsubara, Jun; Niese, S.; Satō, Takashi; Wesenberg, Gro Ramsten; Muramatsu, Y.; Parr, R. M.

doi:10.1007/bf02037199

Cited by 44 publications

(4 citation statements)

References 3 publications

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“…The half-life of most metals in blood is usually measured in weeks [ 15 ]. By contrast, analysis of the metal content of hair is useful in assessing variations in long-term exposure to metals [ 16 ], especially vanadium [ 17 ], arsenic [ 18 ] and mercury [ 19 ]. However, several factors influence metal levels found in hair [ 20 ], and there is strong evidence of disparities between laboratories in hair metal measurements that cannot be attributed to the quality of laboratory methods [ 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

Serum Ferritin and Metal Levels as Risk Factors for Amyotrophic Lateral Sclerosis

Qureshi¹,

Brown²,

Rogers³

et al. 2008

TONEUJ

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Metal toxicity has been identified as a possible risk factor for amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. We conducted a retrospective chart review of urinary, hair and blood metal levels and serum ferritin in 321 people with ALS seen over a ten-year period at the Massachusetts General Hospital (MGH). We found that hair lead levels and serum ferritin levels were elevated in ALS patients compared to published normal values. Metal levels of arsenic, lead, mercury, cadmium, thallium, cobalt and aluminum in 24-hour urine specimens and lead, mercury and arsenic in serum were within the normal range. We conclude that twenty-four hour urine or blood testing for metals is not warranted as part of the evaluation of ALS. Elevated levels of serum ferritin in ALS population could reflect an underlying perturbation in iron metabolism.

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Section: Discussionmentioning

confidence: 99%

Serum Ferritin and Metal Levels as Risk Factors for Amyotrophic Lateral Sclerosis

Qureshi¹,

Brown²,

Rogers³

et al. 2008

TONEUJ

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“…The analysis of hair samples was a slight modification of a previously published methodology. 5 Hair was initially separated from any associated skin and debris. The hair sample was then rinsed with type 1 reagent–grade water (18.3 Mohm-cm water) and placed into a 50-mL polypropylene centrifuge tube.…”

Section: Methodsmentioning

confidence: 99%

Comparison of trace mineral concentrations in tail hair, body hair, blood, and liver of mule deer (Odocoileus hemionus) in California

et al. 2015

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Measuring trace mineral concentrations can be an important component of assessing the health of free-ranging deer. Trace mineral concentrations in liver most accurately reflect the trace mineral status of an individual, but, in live animals, whole blood or serum are the most commonly used sample types. Trace minerals measured in serum, such as copper, zinc, and iron, do not always accurately correlate to liver concentrations, and supplementary samples for evaluating the trace mineral status in live deer would be useful. We evaluated the utility of body and tail hair for measuring selenium, copper, zinc, iron, and manganese in free-ranging mule deer (Odocoileus hemionus) by using Spearman rank correlations and linear regression. Correlations were strongest at the time of or shortly after growth of the winter coat and in resident deer. In live deer, strong correlations and moderate linear associations (R (2) = 0.57) were detected between body and tail hair and whole blood selenium in December. In postmortem-sampled deer, a strong correlation and linear association (R (2) = 0.80) were found between liver and body hair selenium in August-November. Results indicate that body hair, if collected during or shortly after growth of the winter coat, can be used as a supplementary sample for measuring selenium concentrations in deer. None of the other correlations and linear associations were found to be sufficiently strong to conclude that hair can reliably be utilized as a complementary sample for measuring these trace mineral concentrations.

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“…Experimental tests proved that, in some cases, sample washing failed at separating the exogenous from the endogenous components of the trace element [12]. This is the main reason for the controversy on the use of hair to monitor the internal body status [13,14].…”

Section: Cobalt Determination In the Hair Of Patients After Metal-on-...mentioning

confidence: 99%

Cobalt determination in the hair of patients after metal-on-metal hip implants by instrumental neutron activation analysis

D'Agostino¹,

Luzio²,

Oddone³

et al. 2018

Metrologia

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In these years, following the alert of possible problems of toxicity issued by national medicine authorities, thousands of patients with hip implants are recalled for a set of analysis, including cobalt determinations in blood and urine. In this framework, additional measurements of cobalt in hair are recommended to monitor the release of metals in the body after surgery. Aiming at a clinical application, the standardization of the hair washing protocol used to remove possible external contamination is essential. To this aim, a method suggested by the International Atomic Energy Agency and based on repeated washings with acetone and deionized water was tested. Specifically, hair samples of two healthy subjects and three patients were measured at different steps of the washing sequence to observe the decrease in the level of cobalt to the plateau corresponding to the bound component. The data confirmed the suitability of the washing method and proved high levels of bound cobalt in hair of two patients requiring revision hip surgery. Moreover, the cobalt bound component was not affected by the neutron exposure of hair. As a result, use of Instrumental Neutron Activation Analysis might be advantageous compared to other analytical techniques.

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The significance of hair mineral analysis as a means for assessing internal body burdens of environmental pollutants: Results from an IAEA Co-ordinated Research Programme

Cited by 44 publications

References 3 publications

Serum Ferritin and Metal Levels as Risk Factors for Amyotrophic Lateral Sclerosis

Serum Ferritin and Metal Levels as Risk Factors for Amyotrophic Lateral Sclerosis

Comparison of trace mineral concentrations in tail hair, body hair, blood, and liver of mule deer (Odocoileus hemionus) in California

Cobalt determination in the hair of patients after metal-on-metal hip implants by instrumental neutron activation analysis

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