The Significance of Jaundice In Acute Pancreatitis

Frieden, Julian

doi:10.1001/archsurg.1965.01320090100023

Cited by 28 publications

(3 citation statements)

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“…However, icterus is unlikely to be present solely due to pancreatitis in the absence of duct obstruction. 51 Goswami et al 52 reported that 61.4% of patients with leptospirosis had icterus. Another study showed that among patients with leptospirosis, those with icterus had a higher mortality rate (5%-10%) than those without icterus (1%).…”

Section: Discussionmentioning

confidence: 99%

“… 50 Icterus was identified as one of the most common signs in the present review (43%). Frieden 51 reported that the incidence of icterus in patients with AP was 41.3% (n = 75) and that icterus originated from common bile duct enlargement secondary to the inflamed head of the pancreas as evidenced by autopsy. However, icterus is unlikely to be present solely due to pancreatitis in the absence of duct obstruction.…”

Section: Discussionmentioning

confidence: 99%

“…However, icterus is unlikely to be present solely due to pancreatitis in the absence of duct obstruction. 51 …”

Section: Discussionmentioning

confidence: 99%

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Clinical characteristics and outcomes of patients with leptospirosis complicated with acute pancreatitis: a systematic review

Charles,

Jayarajah,

Subasinghe

2023

J Int Med Res

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Objectives Acute pancreatitis (AP) is a severe complication of leptospirosis. This review focuses on the current evidence of AP in patients with leptospirosis. Methods Data on clinical characteristics, biochemical parameters, diagnosis, complications, critical care, fluid management, operative management, and outcomes were analyzed. This study was registered in PROSPERO (CRD42022360802). Results We included 35 individual case reports and 4 case series involving 79 patients. Sex was reported for 48 (60.7%) patients; 38 (48.1%) were male and 10 (12.6%) were female. The patients’ mean age was 45.13 (15–83 years). Acute kidney injury, thrombocytopenia, hypotension, and liver injury were the most common complications reported. Complete recovery was reported for 36 (45.5%) patients. Biochemical and radiological recovery was reported for 10 (12.6%) and 9 (11.3%) patients, respectively. Death was reported in 18 (22.7%) patients. Conclusion A high degree of clinical suspicion and different modalities of investigations are essential in the diagnosis of AP in leptospirosis. AP can be easily missed in leptospirosis because both conditions share similar clinical presentations and complications. Because of the high prevalence of acute kidney injury, judicious fluid management and close monitoring are mandatory.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%