The significance of lymphocytic infiltration of the thyroid gland in thyrotoxicosis

Hargreaves, A W; Garner, A.

doi:10.1002/bjs.1800550712

Cited by 24 publications

(9 citation statements)

References 7 publications

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“…The association of lymphoid follicles with germinal centres with postoperative hypothyroidism has been described,7 8 and we showed a correlation also between the presence of plasma cells and a final hypofunction of the thyroid. We therefore suggest that plasma-cell and other bursa-dependent (B) celular infiltration is important in the pathogenesis of thyroid destruction in Graves's disease.…”

Section: Discussionsupporting

confidence: 80%

Hypothyroidism after Thyroidectomy for Graves's Disease: A Search for an Explanation

Welsum¹,

Feltkamp²,

Vries³

et al. 1974

BMJ

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Section: Discussionsupporting

confidence: 80%

Hypothyroidism after Thyroidectomy for Graves's Disease: A Search for an Explanation

Welsum¹,

Feltkamp²,

Vries³

et al. 1974

BMJ

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“…While LATS is one of the few immunoglobulins to stimulate cells it might well later destroy or exhaust the gland. It appears to cause the type of thyrotoxicosis associated with focal thyroiditis (Mason, 1967) and with a tendency towards under-function without antibody formation-Category I of Hargreaves and Garner (1968). Anderson (1964) thought that this picture was in part due to a delayed hypersensitivity process.…”

Section: Discussionmentioning

confidence: 96%

“…gave a 55 per cent uptake at 6 months. Szilagyi, Barrett, and Preuse (1955) found the incidence of hypothyroidism was only significant below 150mg., but the safety of operation was difficult to ensure below 800-1000 mg. Marchetta, Krause, and Sako (1963) noted that after 'total'thyroidectomy for carcinoma the postoperative scintigram after a few months showed a radioactive iodine uptake of 20-25 per cent.…”

Section: Discussionmentioning

confidence: 98%

The fate and function of the thyroid remnant. A surgical and radioactive iodine study

Young

Macleod

1972

Journal of British Surgery

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SUMMARYClinical, radioactive iodine uptake, and scan studies on a series of measured thyroid remnants indicate that after thyroidectomy one lobe only actively functions in a significant number of cases and that the subthyroid state only appears in toxic cases, usually those with certain pathological, familial, or therapeutically induced changes.Remnant size did not appear to be critical, but under-function did not occur over 8 C.C. Above this size of residuum hypothyroidism does not appear to be directly due to the operation per se and should not therefore be called postoperative.A fall in the assessment parameters after 6 months in a toxic case with a remnant measuring less than 8 C.C. and one or more of the associated features mentioned above would be an indication for commencing thyroxine.Minor degrees of lymphocytic infiltration did not correlate directly with under-function.There was a suggestion of right-sided dominance in the remnant as in normal and diseased glands.

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“…It has been claimed that the incidence of postoperative hypothyroidism after subtotal thyroidectomy is higher in those patients whose thyroids show more extensive lymphoid infiltrate (Whitesell and Black, 1949;Greene, 1950 and1953;Levitt, 1951;Hargreaves and Garner, 1968). Since these reports were based on semiquantitative measurement methods, we have re-investigated this problem using the more accurate histometric technique.…”

mentioning

confidence: 99%

Histometry of lymphoid infiltrate in the thyroid of primary thyrotoxicosis patients. Relation of extent of thyroiditis to preoperative drug treatment and postoperative hypothyroidism.

Young¹,

Sherwood²,

Simpson³

et al. 1976

J Clin Pathol

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It has been claimed that the incidence of postoperative hypothyroidism after subtotal thyroidectomy is higher in those patients whose thyroids show more extensive lymphoid infiltrate (Whitesell and Black, 1949;Greene, 1950 and1953;Levitt, 1951;Hargreaves and Garner, 1968). Since these reports were based on semiquantitative measurement methods, we have re-investigated this problem using the more accurate histometric technique. This paper reports our findings on the relation of the extent of thyroiditis to the preoperative drug treatment regime and to the incidence of postoperative hypothyroidism. Material and Methods CLINICAL INVESTIGATIONSThis study was undertaken on 95 female primary

show abstract

The significance of lymphocytic infiltration of the thyroid gland in thyrotoxicosis

Cited by 24 publications

References 7 publications

Hypothyroidism after Thyroidectomy for Graves's Disease: A Search for an Explanation

Hypothyroidism after Thyroidectomy for Graves's Disease: A Search for an Explanation

The fate and function of the thyroid remnant. A surgical and radioactive iodine study

Histometry of lymphoid infiltrate in the thyroid of primary thyrotoxicosis patients. Relation of extent of thyroiditis to preoperative drug treatment and postoperative hypothyroidism.

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