The Significance of Measuring Vitamin D Serum Levels in Women with Uterine Fibroids

Ciebiera, Michał; Ali, Mohamed; Prince, Lillian; Zgliczyński, Stanisław; Jakiel, Grzegorz; Al-Hendy, Ayman

doi:10.1007/s43032-020-00363-8

Cited by 16 publications

(20 citation statements)

References 101 publications

(173 reference statements)

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“…Overall, the relationship between vitamin D and uterine fibroid metabolism has been characterized. Recently, our research team proposed a preliminary clinical instruction of 25(OH)D measurements and vitamin D supplementation that may be useful for clinicians involved in treating patients with uterine fibroids ( 374 ).…”

Section: Key Pathways Contributing To Uterine Fibroids Formationmentioning

confidence: 99%

Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment

et al. 2021

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Uterine fibroids are benign monoclonal neoplasms of the myometrium, representing the most common tumors in women worldwide. To date, no long-term or non-invasive treatment option exists for hormone-dependent uterine fibroids due to the limited knowledge about the molecular mechanisms underlying the initiation and development of uterine fibroids. This paper comprehensively summarizes the recent research advances on uterine fibroids, focusing on their risk factors, development origin, pathogenetic mechanisms, and treatment options. Additionally, we describe the current treatment interventions for uterine fibroids. Finally, future perspectives on uterine fibroids studies are summarized. Deeper mechanistic insights into tumor etiology and uterine fibroids’ complexity can contribute to the newer targeted therapies.

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Section: Key Pathways Contributing To Uterine Fibroids Formationmentioning

confidence: 99%

Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment

et al. 2021

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“…In a later study, Wise identified single-nucleotide polymorphisms in genes involved in vitamin D metabolism that were significantly associated with UFs [ 121 ]. It has also been shown African American women have lower serum vitamin D levels than white Americans, which could explain the increased risk of UFs [ 122 ]. Al Hendy et al observed that vitamin D could be a potent antiestrogenic agent that reduces the expression of sex steroid receptors and consequently the risk of UFs [ 123 ].…”

Section: Uterine Fibroidsmentioning

confidence: 99%

“…Al Hendy et al observed that vitamin D could be a potent antiestrogenic agent that reduces the expression of sex steroid receptors and consequently the risk of UFs [ 123 ]. Vitamin D has been shown to be a potent antitumor agent inhibiting UF cell proliferation and decreasing UF size in in vivo animal models as well as several clinical trials [ 122 , 124 , 125 ]. Mechanistically, vitamin D might exert its anti-UF effects via induction of DNA repair genes and amelioration of DNA damage both in UF cells and in myometrial cells at risk of developing UFs [ 126 , 127 , 128 ].…”

Section: Uterine Fibroidsmentioning

confidence: 99%

Nutrition in Gynecological Diseases: Current Perspectives

et al. 2021

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Diet and nutrition are fundamental in maintaining the general health of populations, including women’s health. Health status can be affected by nutrient deficiency and vice versa. Gene–nutrient interactions are important contributors to health management and disease prevention. Nutrition can alter gene expression, as well as the susceptibility to diseases, including cancer, through several mechanisms. Gynecological diseases in general are diseases involving the female reproductive system and include benign and malignant tumors, infections, and endocrine diseases. Benign diseases such as uterine fibroids and endometriosis are common, with a negative impact on women’s quality of life, while malignant tumors are among the most common cause of death in the recent years. In this comprehensive review article, a bibliographic search was performed for retrieving information about nutrients and how their deficiencies can be associated with gynecological diseases, namely polycystic ovary syndrome, infertility, uterine fibroids, endometriosis, dysmenorrhea, and infections, as well as cervical, endometrial, and ovarian cancers. Moreover, we discussed the potential beneficial impact of promising natural compounds and dietary supplements on alleviating these significant diseases.

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“…Vitamin D also has its specific type of receptorvitamin D receptor (VDR). Binding with VDR, vitamin D mediates its pleiotropic functions through steroid transcriptional mechanisms 123,124 .…”

Section: Endocrine-disrupting Chemicals and Inflammation In The Pathogenesis Of Ufsmentioning

confidence: 99%

Endocrine-Disrupting Chemicals and Vitamin D Deficiency in the Pathogenesis of Uterine Fibroids

Elkafas

Badary

Elmorsy

et al. 2021

Journal of Advanced Pharmacy Research

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Uterine fibroids (UFs) are the most prevalent gynecologic neoplasm, affecting 70-80% of women over their lifespan. Although UFs are benign they can become life-threatening and require invasive surgeries such as myomectomy and hysterectomy. Notwithstanding the significant negative influence UFs have on female reproductive health, very little is known about early events that initiate tumor development. Several risk factors for UFs have been identified including vitamin D deficiency, inflammation, DNA repair deficiency, and environmental exposures to endocrine-disrupting chemicals (EDCs). EDCs have come under scrutiny recently due to their role in UF development. Epidemiologic studies have found an association between increased risk for early UF diagnosis and in utero EDC exposure. Environmental exposure to EDCs during uterine development increases UF incidence in a UF animal model. Notably, several studies demonstrated that abnormal myometrial stem cells (MMSCs) are the cell origin for UFs development. Our recent studies demonstrated that early-life EDC exposure reprogrammed the MMSCs toward a pro-fibroid landscape and altered the DNA repair and inflammation pathways. Notably, Vitamin D3 (VITD3) as a natural compound shrank the UF growth concomitantly with the reversion of several abnormal biological pathways and ameliorated the developmental exposureinduced DNA damage and pro-inflammation pathway in primed MMSCs. This review highlights and emphasizes the importance of multiple pathway interactions in the context of hypovitaminosis D at the MMSCs level and provides proofof-concept information that can help develop a safe, long-term, durable, and non-surgical therapeutic option for UFs.

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The Significance of Measuring Vitamin D Serum Levels in Women with Uterine Fibroids

Cited by 16 publications

References 101 publications

Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment

Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment

Nutrition in Gynecological Diseases: Current Perspectives

Endocrine-Disrupting Chemicals and Vitamin D Deficiency in the Pathogenesis of Uterine Fibroids

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