The Significance of Mycobacterium abscessus Subspecies abscessus Isolation During Mycobacterium avium Complex Lung Disease Therapy

Griffith, David E.; Philley, Julie V.; Benwill, Jeana L.; Sulzbach, Sara; York, Deanna; Wallace, Richard J.

doi:10.1378/chest.14-1297

Cited by 39 publications

(27 citation statements)

References 19 publications

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“…In previous studies of NTM lung disease caused by MAC or MABC, the range of reported prevalences of mixed infection by both pathogens was wide at 8% to 61%, depending on the study population and the definition of mixed infection (17,19,22,25). However, most of these studies evaluated the development of another infection during the disease course of the primary infection (17,19) or encompassed the past infection as well as a coexistent infection (22,25), whereas our study investigated only concomitant mixed infections.…”

Section: Discussionmentioning

confidence: 92%

“…In a study of MAC lung disease, 29% (5/17) of the patients with nodular bronchiectatic MAC lung disease, but none with upper lobe cavitary disease, had M. abscessus infection (20). Another study of nodular bronchiectatic MAC lung disease also found that 29% of the subjects harbored M. abscessus during therapy for MAC lung disease (17). Similarly, in a study of M. abscessus lung disease in which nearly all (98%) of the study subjects had bronchiectasis and nodular opacities, the prevalence of coexistent or previous MAC infection was as high as 55% (22).…”

Section: Discussionmentioning

confidence: 99%

“…Since exposure to these organisms is inevitable, the majority of patients who develop NTM lung disease likely have underlying respiratory diseases, such as chronic obstructive pulmonary disease or bronchiectasis, which make them vulnerable to NTM infections (9,10). In addition, recurrence of NTM lung disease caused by the same species and redevelopment of NTM lung disease caused by other NTM organisms are not uncommon after treatment of the previous NTM lung disease is completed (11)(12)(13)(14)(15)(16)(17)(18).…”

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confidence: 99%

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Nontuberculous Mycobacterial Lung Diseases Caused by Mixed Infection with Mycobacterium avium Complex and Mycobacterium abscessus Complex

Shin

Jhun

Kim

et al. 2018

Antimicrob Agents Chemother

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complex (MAC) and complex (MABC) comprise the two most important human pathogen groups causing nontuberculous mycobacterial lung disease (NTM-LD). However, there are limited data regarding NTM-LD caused by mixed NTM infections. This study aimed to evaluate the clinical characteristics and treatment outcomes in patients with NTM-LD caused by mixed infection with these two major NTM pathogen groups. Seventy-one consecutive patients who had been diagnosed with NTM-LD caused by mixed infection with MAC ( or ) and MABC ( or ) between January 2010 and December 2015 were identified. Nearly all patients (96%) had the nodular bronchiectatic form of NTM-LD. Mixed infection with MAC and ( = 47, 66%) was more common than mixed infection with MAC and ( = 24, 34%), and among the 43 (61%) patients who were treated for NTM-LD for more than 12 months, sputum culture conversion rates were significantly lower in patients infected with MAC and (25% [3/12]) than in patients infected with MAC and (61% [19/31, = 0.033]). Additionally, and showed marked differences in clarithromycin susceptibility (90% versus 6%, < 0.001). Of the 23 patients who successfully completed treatment, 11 (48%) redeveloped NTM lung disease, with mycobacterial genotyping results indicating that the majority of cases were due to reinfection. Precise identification of etiologic NTM organisms could help predict treatment outcomes in patients with NTM-LD due to mixed infections.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Nontuberculous Mycobacterial Lung Diseases Caused by Mixed Infection with Mycobacterium avium Complex and Mycobacterium abscessus Complex

Shin

Jhun

Kim

et al. 2018

Antimicrob Agents Chemother

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“…Coinfection with MAC and M. abscessus subsp. abscessus occurs and may be associated with new or enlarged cavities in case of additional M. abscessus -PD [59]. This underlines the necessity of regular microbiological and clinical follow-ups to determine which patients truly have M. abscessus -associated lung disease during the course of MAC-PD.…”

Section: Clinical Presentationmentioning

confidence: 99%

Pulmonary Disease Caused by Non-Tuberculous Mycobacteria

Wassilew¹,

Hoffmann²,

Andréjak³

et al. 2016

Respiration

128

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Non-tuberculous mycobacteria (NTM) include more than 160 ubiquitous, environmental, acid-fast-staining bacterial species, some of which may cause disease in humans. Chronic pulmonary infection is the most common clinical manifestation. Although patients suffering from chronic lung diseases are particularly susceptible to NTM pulmonary disease, many affected patients have no apparent risk factors. Host and pathogen factors leading to NTM pulmonary disease are not well understood and preventive therapies are lacking. NTM isolation and pulmonary disease are reported to rise in frequency in Europe as well as in other parts of the world. Differentiation between contamination, infection, and disease remains challenging. Treatment of NTM pulmonary disease is arduous, lengthy, and costly. Correlations between results of in vitro antibiotic susceptibility testing and clinical treatment outcomes are only evident for the Mycobacterium avium complex, M. kansasii, and some rapidly growing mycobacteria. We describe the epidemiology of NTM pulmonary disease as well as emerging NTM pathogens and their geographical distribution in non-cystic fibrosis patients in Europe. We also review recent innovations for the diagnosis of NTM pulmonary disease, summarize treatment recommendations, and identify future research priorities to improve the management of patients affected by NTM pulmonary disease.

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“…A recent report considered 53 patients encountered over a 12-year period who received treatment for MAC PNTM and had M abscessus subspecies abscessus ( Maa ) isolated during therapy. 40 …”

Section: Recent Insightsmentioning

confidence: 99%

Pulmonary Disease Due to Nontuberculous Mycobacteria

McShane

Glassroth

2015

Chest

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The Significance of Mycobacterium abscessus Subspecies abscessus Isolation During Mycobacterium avium Complex Lung Disease Therapy

Abstract: BACKGROUND: Isolation of Mycobacterium abscessus subspecies abscessus (MAA) is common during Mycobacterium avium complex (MAC) lung disease therapy, but there is limited information about the clinical signifi cance of the MAA isolates.

Cited by 39 publications

References 19 publications

Nontuberculous Mycobacterial Lung Diseases Caused by Mixed Infection with Mycobacterium avium Complex and Mycobacterium abscessus Complex

Nontuberculous Mycobacterial Lung Diseases Caused by Mixed Infection with Mycobacterium avium Complex and Mycobacterium abscessus Complex

Pulmonary Disease Caused by Non-Tuberculous Mycobacteria

Pulmonary Disease Due to Nontuberculous Mycobacteria

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