The significance of myositis autoantibodies in idiopathic inflammatory myopathy concomitant with interstitial lung disease

Huang, Hsien‐Cheng; Lin, Wen‐Shan; Lin, Po-Yu; Weng, Meng Yu; Sun, Yuan

doi:10.1007/s10072-020-04911-7

Cited by 12 publications

(22 citation statements)

References 42 publications

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“…Even without modification of the main category of myopathy, the changes in the subtype of IIM are of clinical significance. Subtypes of IIM are highly relevant to the effectiveness of treatments, the frequency of concomitant ILD, and the ratio of concurrent malignancy [ 51 , 52 ]. The accurate diagnosis of IIM subtypes guides clinicians on the frequency and extensiveness of cancer surveillance [ 53 , 54 ] and suggests the prognosis of pulmonary complications [ 37 , 51 , 52 , 55 , 56 , 57 , 58 ].…”

Section: Discussionmentioning

confidence: 99%

“…Subtypes of IIM are highly relevant to the effectiveness of treatments, the frequency of concomitant ILD, and the ratio of concurrent malignancy [ 51 , 52 ]. The accurate diagnosis of IIM subtypes guides clinicians on the frequency and extensiveness of cancer surveillance [ 53 , 54 ] and suggests the prognosis of pulmonary complications [ 37 , 51 , 52 , 55 , 56 , 57 , 58 ]. In addition, unlike most primary muscle diseases, IIMs are treatable and should not be misdiagnosed as other hereditary or degenerative myopathies.…”

Section: Discussionmentioning

confidence: 99%

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Muscle Biopsy: A Requirement for Precision Medicine in Adult-Onset Myopathy

Liao

Lin

et al. 2022

JCM

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Muscle biopsy is a fundamental procedure to assist the final diagnosis of myopathy. With the recent advances in molecular diagnosis, serology tests, and mechanism-based classification in myopathy, the précised diagnosis for myopathy required the applications of multiple tools. This study intends to reappraise the benefit of muscle biopsy in adult-onset myopathy under the setting of an optimized muscle biopsy protocol and comprehensive serology tests. A one-group pretest-posttest study design was used. The pre- and post-biopsy diagnoses and treatments in 69 adult patients were compared. Muscle biopsy yielded 85.5% of definitive diagnoses, including changes in pre-biopsy diagnoses (40.6%) and narrowing down the suspicious myopathies (49.3%). The demographic data and clinical parameters between the group “with change” and “without change” after biopsy were not different. Among those with changes in diagnosis, 39.3% also had a corresponding shift in treatment, which benefits the patients significantly. Regarding the most common adult-onset myopathy, idiopathic inflammatory myopathy (IIM), 41% of patients with pre-biopsy diagnosis as IIM had changes in their IIM subtype diagnosis, and 53% was finally not IIM after muscle biopsy. Although there have been advances in molecular diagnosis recently, muscle biopsy still undoubtedly critically guided the diagnosis and treatment of adult-onset myopathy in the era of precision medicine.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Muscle Biopsy: A Requirement for Precision Medicine in Adult-Onset Myopathy

Liao

Lin

et al. 2022

JCM

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“…Serum IL-17 levels were higher in ASS patients than in matched HCs, although apparently unrelated with the disease activity (83). The presence of anti-Ro52, anti-Jo1, anti-PL7 and anti-EJ seemed to predict the development of ILD in IIM patients (84,85), whereas aldolase predicted the positivity of one MSA/MAA in an ILD cohort tested for anti-Ro/SSA, ANA, aldolase and CK (86). Regarding ASS, an observational study reported that anti-ARS patients may satisfy criteria for many rheumatic diseases, although attention should always be paid to the possible development of ILD or myositis (87).…”

Section: Laboratory Investigations and Autoantibodiesmentioning

confidence: 98%

Idiopathic inflammatory myopathies: one year in review 2021

Cardelli

Zanframundo

Cometi

et al. 2022

Clinical and Experimental Rheumatology

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Idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of rare and complex connective tissue diseases, mainly characterised by inflammatory involvement of skeletal muscles. Several other organs may be affected, particularly lungs, heart, skin, gastrointestinal tract and joints, often determining the morbidity and mortality associated with these autoimmune disorders. The course is generally chronic and the onset subacute. This latter aspect, together with the rarity of these conditions, can result in a clinical challenge for the physician with a considerable diagnostic delay. The scientific literature makes continuous advances in the understanding of these diseases, in particular with regards to the pathogenesis, serological findings, diagnostic strategies and therapeutic approaches. The aim of this review is to highlight the most relevant literature contributions published on this topic over the last year.

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“…such as arthritis, [11] with or without mild myopathy, [11] facial rash, [11] and mechanic's hand. [40] Testing for the presence of MSAs and myositis-associated autoantibodies (MAAs) completes the clinical evaluation of IIMs. Patients who test positive for anti-ARS antibodies frequently present with ILD, [11,39,41] particularly anti-Jo1, [11,40,41] anti-PL7, [42] anti-PL12, [42] and anti-OJ [11] antibodies.…”

Section: Journal Of Translational Internal Medicine / Aopmentioning

confidence: 99%

“…[40] Testing for the presence of MSAs and myositis-associated autoantibodies (MAAs) completes the clinical evaluation of IIMs. Patients who test positive for anti-ARS antibodies frequently present with ILD, [11,39,41] particularly anti-Jo1, [11,40,41] anti-PL7, [42] anti-PL12, [42] and anti-OJ [11] antibodies. The clinical spectrum of anti-ARS autoantibodies includes fever, mechanic's hand, arthritis, myositis, Raynaud's phenomenon, and ILD.…”

Section: Journal Of Translational Internal Medicine / Aopmentioning

confidence: 99%

Predictors of progression in idiopathic inflammatory myopathies with interstitial lung disease

Huang

Chang

Zhu³

et al. 2022

Journal of Translational Internal Medicine

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The idiopathic inflammatory myopathies (IIMs) are a group of connective tissue diseases that afect multiple organ systems, including the lungs. Interstitial lung disease (ILD) is the most common and heterogeneous complication of IIMs, with its degree ranging from mild to fatal. Thus, it is critical to identify clinical features and validated biomarkers for predicting disease progression and prognosis, which could be beneficial for therapy adjustment. In this review, we discuss predictors for rapid progression of IIM-ILD and propose guidance for disease monitoring and implications of therapy. Systematic screening of myositis-specific antibodies, measuring serum biomarker levels, pulmonary function tests, and chest high-resolution computer tomography will be beneficial for the evaluation of disease progression and prognosis.

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The significance of myositis autoantibodies in idiopathic inflammatory myopathy concomitant with interstitial lung disease

Cited by 12 publications

References 42 publications

Muscle Biopsy: A Requirement for Precision Medicine in Adult-Onset Myopathy

Muscle Biopsy: A Requirement for Precision Medicine in Adult-Onset Myopathy

Idiopathic inflammatory myopathies: one year in review 2021

Predictors of progression in idiopathic inflammatory myopathies with interstitial lung disease

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