The significance of PSA modified parameters (F/T)/PSAD for diagnosing prostatic cancer in the grey zone of 4∼10 ng/ml

Significant Diagnostic Value of Free-Serum PSA (FPSA)/Prostate-Specific Antigen Density (PSAD) and (F/T)/PSAD for Prostate Cancer of the Chinese Population in a Single Institution

“…Results from this study share similarity with an earlier study by Yan et al (2007) [15], which showed significantly higher specificity of (F/T)/PSAD than F/T. Although the specificity of (F/T)/PSAD appeared higher than that of PSAD, it was not statistically significant.…”

“…Secondly, age is a prominent factor leading to an increase in prostate cancer risk [21–23], and multiple regression analysis performed in this study showed PV, PSAD, and (F/T)/PSAD as independent predictors of prostate cancer regardless of age. Thirdly, the sample size in this study was higher than in the study of Yan et al [15]. In addition, a newly calculated parameter FPSA/PSAD analyzed in this study showed similar diagnostic accuracy with (F/T)/PSAD.…”

“…Veneziano et al [14] combined these 2 parameters and proposed a new parameter (F/T)/PSAD, which was superior to F/T or PSAD alone for the diagnosis of prostate cancer in the Italian population. A previous study in the Chinese population with PSA of 4~10 ng/mL also showed significantly higher specificity with (F/T)/PSAD than F/T and PSAD alone [15]. However, sensitivity and specificity are still not satisfactory.…”