The Significance of Recognizing Myocardial Bridge in the Coronary Spasm Diagnosis in Myocardial Infarction with Nonobstructive Coronary Arteries

Teragawa, Hiroki; Oshita, Chikage; Ueda, Toshihisa

doi:10.2169/internalmedicine.3266-19

Cited by 3 publications

(3 citation statements)

References 22 publications

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“…MB can increase the risk of developing coronary artery spasm, [ 34 ] which has been shown to be an important cause of MI and non-obstructive coronary arteries. [ 35 , 36 ] Hiroki Teragawa et al [ 37 ] reported a case of non-obstructive coronary MI and detected the presence of coronary artery spasm in the patient MB segments by spasm provocation test, which may be related to the constrictive kinking of the vessels leading to their endothelial dysfunction and increased local vascular reactivity to systemic vasoconstrictor stimulation. [ 27 ] Purumeh Nam et al [ 38 ] performed acetylcholine stimulation test and found that the incidence of coronary artery spasm was 59.1%, and patients with MB combined coronary artery spasm had a highrate of angina recurrence, proving that MB are one of the important risk factors for coronary artery spasm.…”

Section: Discussionmentioning

confidence: 99%

A bibliometric analysis of myocardial bridge combined with myocardial infarction

Zhang,

Cao

2024

Medicine

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Background: The aim of this study is to analyze the process and frontiers of research in myocardial bridges (MB) to identify future research directions in the last 3 decades. Methods: Relevant literature on MB combined with myocardial infarction (MI) was searched from 1991 to 2023 in the Web of Science database, and was analyzed by bibliometric analysis using VOSviewer, CiteSpace, and the R package “bibliometrix.” Results: A total of 1233 English articles were included in this study. The number of published articles showed an increasing trend yearly. From 2017 to 2022, the annual publication volume rose rapidly, and in 2021 the publication volume even reached 95 articles, which was the highest in all years. These publications were from 68 countries and 1854 institutions, with the leading country being the U.S. and the leading institution being Columbia University. Myoho Clinical International has a close collaborative relationship with Columbia University, while in recent years, the Harvard Medical School has explored the study of MB combined with MI. Annals of Thoracic Surgery was the journal with the highest number of publications, and Takayama Hiroo and Naka Yoshifumi were the authors with the highest number of publications. The most common keywords were MI, cardiogenic shock, and MB. Conclusions: Our findings can help researchers explore the current status of MB combined with MI research and choose new survey routes for upcoming studies. Prevalence and prognosis, mechanism of MB combined with MI and molecular mechanism may become the focus of future research. In addition, more research and cooperation are needed worldwide.

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Section: Discussionmentioning

confidence: 99%

A bibliometric analysis of myocardial bridge combined with myocardial infarction

Zhang,

Cao

2024

Medicine

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“…Some patients with vasospastic angina (VSA) experience prolonged chest symptoms[ 1 ]. The guidelines for VSA[ 2 ] note that chest pain in patients with VSA usually occurs at rest, with pain persisting for several minutes up to approximately 15 min.…”

Section: Introductionmentioning

confidence: 99%

Clinical significance of prolonged chest pain in vasospastic angina

Teragawa¹,

Oshita²,

Orita³

2020

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BACKGROUND Patients with vasospastic angina (VSA) sometimes experience prolonged chest symptoms. The clinical characteristics of these patients have not been clarified. AIM To investigate the clinical characteristics of prolonged VSA patients. METHODS This study included 167 patients with VSA diagnosed by spasm provocation tests (SPTs) using acetylcholine, which recorded the frequencies of positive reactions to a low dose of acetylcholine (L-ACh), total occlusion due to spasm (TOC), focal spasm, and the unavoidable use of nitroglycerin (unavoidable-NTG) during SPTs. The patients underwent a medical interview that investigated the maximum duration and frequency of chest symptoms as well as the frequencies of variant angina and other serious symptoms. The patients were divided into two groups based on the maximal duration: The short-duration group (< 15 min; n = 114) and the long-duration group (≥ 15 min; n = 53). They were also divided into two groups based on the frequency of chest symptoms: The low-frequency group (< 4/mo; n = 88) and the high-frequency group (≥ 4/mo; n = 79). RESULTS The long-duration group showed higher frequencies of other serious symptoms ( P < 0.001) and variant angina ( P < 0.05) as well as higher frequencies of spasm induction by L-ACh ( P < 0.05), TOC ( P < 0.05), focal spasm ( P < 0.01), and unavoidable-NTG ( P < 0.01) than the short-duration group. These parameters did not differ significantly between the low-frequency and high-frequency groups. CONCLUSION These findings suggest that patients with VSA who experience prolonged chest symptoms may have more severe characteristics of VSA.

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“…It is well-known that coronary spastic angina, also known as vasospastic angina (VSA), is characterized by transient vasoconstriction of epicardial coronary arteries, leading to myocardial ischemia ( 1 - 3 ). Coronary artery spasm causes rest angina, exertional angina, acute myocardial infarction, sudden cardiac death, and heart failure ( 3 - 5 ). The mechanisms of coronary artery spasm are multi-factorial and include an abnormal autonomic nervous system response, endothelial dysfunction in the coronary artery or systemic peripheral vasculature, vascular smooth muscle cell hyperresponsiveness, magnesium deficiency, genetics, and a certain anatomy of the coronary arteries ( 3 , 6 - 8 ).…”

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confidence: 99%

The Significance of Recognizing Myocardial Bridge in the Coronary Spasm Diagnosis in Myocardial Infarction with Nonobstructive Coronary Arteries

Cited by 3 publications

References 22 publications

A bibliometric analysis of myocardial bridge combined with myocardial infarction

A bibliometric analysis of myocardial bridge combined with myocardial infarction

Clinical significance of prolonged chest pain in vasospastic angina

Spasm Provocation Test Using Acetylcholine in Patients with Bronchial Asthma: An Important Step Forward

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