The significance of reduced glutathione and glutathione S-transferase during chemoradiotherapy of locally advanced cervical cancer

Daukantienė, Lina; Kazbarienė, Birutė; Valuckas, Konstantinas Povilas; Didžiapetrienė, Janina; Krikstaponiene, Aurelija; Aleknavičius, Eduardas

doi:10.1016/j.medici.2014.09.005

Cited by 7 publications

(5 citation statements)

References 19 publications

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“…Greater numbers of specimens would be necessary to confirm this finding. High mRNA expression levels of LRP and GSTP1 may mediate drug resistance of tumor cells to cisplatin, suggesting that primary MDR of CC to cisplatin may be associated with the expression levels of LRP and GSTP1 genes (18).…”

Section: Discussionmentioning

confidence: 99%

Expression levels of resistant genes affect cervical cancer prognosis

Yang

Gao

et al. 2017

Molecular Medicine Reports

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Tumor cells may develop multidrug resistance (MDR) to various chemotherapy regimens. Such resistance reduces the sensitivity of cells to chemotherapy drugs, leading to the failure of cervical cancer (CC) treatment and disease progression. The present study aimed to investigate the role of MDR1, lung resistance protein (LRP) and placental glutathione S‑transferase π 1 (GSTP1) in CC and MDR, and the prognostic value of these genes. The mRNA expression levels of these resistance‑associated genes were determined in 47 CC and 20 healthy cervical tissue samples. Subsequently, the data was analyzed alongside clinicopathological parameters. The mRNA expression levels of MDR1, LRP and GSTP1 in CC were 0.57±0.32, 0.58±0.29 and 0.44±0.24, respectively, whereas those in healthy cervical tissues were 0.19±0.10, 0.17±0.14 and 0.18±0.10, respectively. Therefore, the expression levels of these genes were significantly greater in CC compared with healthy cervical tissue (P<0.05). mRNA expression levels of MRD1 were increased in the well differentiated group (0.68±0.27) compared with the poorly differentiated group (0.38±0.33; P<0.05). No significant differences were observed between LRP and GSTP1 mRNA expression levels and tumor differentiation or clinical stage of the patients (P>0.05). Multivariate logistic regression indicated that the degree of differentiation and the MDR1 gene expression levels were predictors of CC prognosis (P<0.05). The survival rate of patients in the MDR1‑negative group was significantly greater compared with the MDR1‑positive group (P<0.05). The results of the present study therefore suggested that MDR1 gene expression is a predictor of poor survival in CC.

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Section: Discussionmentioning

confidence: 99%

Expression levels of resistant genes affect cervical cancer prognosis

Yang

Gao

et al. 2017

Molecular Medicine Reports

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“…Moreover, reduced GSH levels are associated with patient's response to treatment . Predictive role of GSH for patients with CC undergoing chemoradiotherapy is also shown by Daukantienė et al and Vidyasagar et al Srivastava et al demonstrated that increased lipid peroxidation and reduced levels of GSH, SOD, Vitamin A, and E in patients with CC are significantly associated with tumor stage, suggesting their clinical significance as prognostic markers . In contrast, Sharma et al reported higher levels of GSH in patients with CC following chemotherapy .…”

Section: Diagnostic and Predictive Value Of Oxidative Stress Status I...mentioning

confidence: 89%

Oxidative stress in cervical cancer pathogenesis and resistance to therapy

Ebrahimi

Soltani

Hashemy

2018

J of Cellular Biochemistry

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Cervical cancer (CC) is one of the most common cancers among females, and it is most notable in developing countries. The exact etiology of CC is poorly understood; but, smoking, oral contraceptives, immunosuppression, and infection with human papillomavirus (HPV) may increase the risk of CC. There is also an association between CC and oxidative stress. Oxidative stress is caused by a disturbed oxidant‐antioxidant balance in favor of the former, leading to an excessive generation of free radicals, particularly reactive oxygen species (ROS), and subsequently to biological damages. Thus, redox enzymatic and nonenzymatic regulators are required to maintain the redox homeostasis. Dysregulated antioxidants system and the pathogenic role of oxidative stress in CC have been investigated in several clinical and preclinical studies. In this study, we reviewed studies that have addressed the cross‐talk between oxidative stress and CC pathogenesis and resistance to therapy.

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“…Our own data also suggest that ionizing radiation leads to an enhanced consumption of glutamine 24 h after radiation, 110 most likely as a response to oxidative stress to generate more glutathione 212 (Figure 4). There is also evidence that glutathione levels are increased by radiation in the context of cancer 57,214 . In addition to glutamate, glutathione is made from cysteine and glycine, the latter of which can either be imported or synthesized from serine.…”

Section: Changes To Major Metabolic Pathways Induced By Ionizing Radiationmentioning

confidence: 99%

Metabolic response to radiation therapy in cancer

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Bailleul

Vlashi

et al. 2021

Molecular Carcinogenesis

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Tumor metabolism has emerged as a hallmark of cancer and is involved in carcinogenesis and tumor growth. Reprogramming of tumor metabolism is necessary for cancer cells to sustain high proliferation rates and enhanced demands for nutrients. Recent studies suggest that metabolic plasticity in cancer cells can decrease the efficacy of anticancer therapies by enhancing antioxidant defenses and DNA repair mechanisms. Studying radiation‐induced metabolic changes will lead to a better understanding of radiation response mechanisms as well as the identification of new therapeutic targets, but there are few robust studies characterizing the metabolic changes induced by radiation therapy in cancer. In this review, we will highlight studies that provide information on the metabolic changes induced by radiation and oxidative stress in cancer cells and the associated underlying mechanisms.

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The significance of reduced glutathione and glutathione S-transferase during chemoradiotherapy of locally advanced cervical cancer

Cited by 7 publications

References 19 publications

Expression levels of resistant genes affect cervical cancer prognosis

Expression levels of resistant genes affect cervical cancer prognosis

Oxidative stress in cervical cancer pathogenesis and resistance to therapy

Metabolic response to radiation therapy in cancer

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