The Significance of Routine Laboratory Parameters in Patients with Sudden Sensorineural Hearing Loss

Abstract

There are several factors (viral infections, metabolic and ototoxic disorders etc.) accused for the development of sudden sensorineural hearing loss. Some prognostic factors (late onset of treatment etc.) had been evaluated in the literature. There is no sufficient data on the effect of routine laboratory parameters on the development and/or prognosis of sudden sensorineural hearing loss. The aim of this study is to investigate the effects of routine blood chemistry and hematological parameters on the development and prognosis of disease in patients with idiopathic sudden sensorineural hearing loss. One hundred and forty-seven patients with the diagnosis of idiopathic sudden sensorineural hearing loss followed up during the periods of 2000-2010 years were included in this study.One hundred and three septoplasty patients with no otologic complaints were enrolled as control group. Following the clinical and demographic evaluations, patients with idiopathic sudden sensorineural hearing loss and control groups, and patients treated successfully and patients with poor outcome were compared with each other. Data were analyzed by T test. All hematological and biochemical parameters were compared. Hemoglobin, hematocrit, white blood cell count, total and direct bilirubin, fasting blood glucose level and aspartate aminotransferase were significantly different between idiopathic sudden sensorineural hearing loss and control groups. There was no significantly different parameter between patients treated successfully and patients with poor outcome. Hemoglobin, hematocrit, white blood cell count, total and direct bilirubin, fasting blood glucose level and AST all can be risk factors for SHL, or they can be the result of undetermined pathology, because these parameters have no effect on the prognosis. Other routine parameters seem to have no effect on the development and/or prognosis of idiopathic sudden sensorineural hearing loss.

Sudden sensorineural hearing loss: is there a relationship between routine haematological parameters and audiogram shapes?

“…On the contrary, Sagit et al (2013) and Seo et al (2014) analysing, respectively, haematological data of 31 and 348 SSNHL patients evidenced a significant difference in PC values between subjects with and without SSNHL. Furthermore, Yasan et al (2013), Wittig et al (2014), Quaranta et al (2015), Kum et al (2015) did not recognise PC as prognostic factor for hearing recovery (p40.05).…”

Association between routine hematological parameters and sudden sensorineural hearing loss: A meta-analysis

“…From the remaining 44 articles, we excluded one study because it was not published in English, seven articles as they lacked outcomes of interest, five articles that did not give the mean and standard deviation of NLR, PLR, and MPV values, two articles that reported the same population, six letters, and five articles that focused on other topics. Finally, 18 studies ( Ulu et al., 2013 ; K et al., 2016 ; Qiao et al., 2019 ; Karli et al., 2013 ; Ikinciogullari et al., 2014 ; Lee et al., 2017 ; Zheng et al., 2014 ; Yasan et al., 2013 ; Seo et al., 2014 ; Sagit et al., 2013 ; Quaranta et al., 2015 ; Ozler, 2014 ; Nonoyama et al., 2016 ; Mirvakili et al., 2016 ; Kum et al., 2015 ; Kocak et al., 2017 ; Ha et al., 2019 ; Bulğurcu et al., 2017 ) were eligible for meta-analysis. ( Fig.…”

Role of Obesity on the Prognosis of Sudden Sensorineural Hearing Loss in Adults

“…These data were very similar to those of other studies. [12][13][14][15][16][17][18][19][20][21][22] The role of HTN on the prognosis of SSHL in our study was different from that of Hirano et al, 13 Nagaoka et al, 14 and Shikowitz 15 but was similar to that of Mosnier et al 20 and Lionello et al 21 As for the role of age, our current result was slightly different from that of Wang et al 16 and Lionello et al 21 Statistically, hearing level was in fact a continuous variable but was arbitrarily defined into a category variable for outcome calculation. Second, treatment protocols might contribute variably to the treatment outcomes.…”

“…Thus, the contradictory results between these articles mentioned above and ours might be due to the differences in the outcome definition and/or treatment protocols. [12][13][14][15][16][17][18][19][20][21][22][23][24] In addition, the merit of this study over other published similar studies is that we have proposed a novel possible factor (obesity/overweight) on the prognosis of SSHL, although a negative result was shown. Adipose tissue is now considered to be an endocrine tissue.…”

“…For example, there were no differences in remission rates for SSHL patients with preexisting sensorineural hearing loss, previous episode of SSHL, or chronic otitis media. 19 Vertigo, 20 audiogram type, cardiovascular and thromboembolic risk factors, time elapsed from onset of SSHL to hospitalization, 20,21 or routine laboratory parameters 22 were not associated with recovery of SSHL. Lionello et al 21 concluded that only age was significantly and independently related to hearing outcome among all known factors.…”