The significance of serum total immunoglobulin E for in vitro diagnosis of allergic rhinitis

Chung, Daniel C.; Park, K.T.; Yarlagadda, Bharat B.; Davis, Elizabeth Mahoney; Platt, Michael P.

doi:10.1002/alr.21240

Cited by 23 publications

(13 citation statements)

References 21 publications

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“…In vitro testing for specific IgE may be unnecessary in patients with low serum total IgE, whereas high total IgE level suggests that in vitro testing would confirm specific sensitizations in patients with allergic rhinitis. 13 In the present study serum IgE level was increased in all patients. In the study conducted by Naspitz et al, total IgE serum levels in the control group exhibited a tendency towards more elevated values in older children.…”

Section: Discussionsupporting

confidence: 61%

A clinical study of inhalant allergens in patients with allergic rhinitis

Choudhari

Sangavi

2017

Int J Otorhinolaryngol Head Neck Surg

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INTRODUCTIONImmunoglobulin E (IgE) predominantly mediates immunity and immune responses against parasitic infections, but it is also an essential component of type I hypersensitivity reaction, which can cause anaphylaxis, asthma, atopic dermatitis, and allergic rhinitis.1 Allergic rhinitis was defined in 1929, it is a symptomatic disorder of the nose induced after allergen exposure by an immunoglobulin E (IgE)-mediated inflammation of the membranes lining the nose. It is a global health problem that causes major illness and disability worldwide. The three cardinal symptoms in nasal reactions occurring in allergy are sneezing, nasal obstruction and mucous discharge.2 It is the cause, coexisting disorder or predisposing factor in many cases of chronic sinusitis, serous otitis, increased susceptibility to upper and lower respiratory infections and orthodontic disorders such as overbite and maldeveloped dental archs. 3The basis of any diagnosis of allergy requires a good history and examination, which should then provide a certain degree of confidence as to whether or not allergy is present. However, the diagnosis cannot be confirmed on the basis of symptoms alone, because both allergic and non-allergic conditions can present with similar symptoms. Hence, allergy testing in the form of specific IgE (sIgE) measurement is an important aid in demonstrating both the presence and severity of such an allergy. 4 ABSTRACT Background:The basis of diagnosis of allergy requires a good history and examination, however, the diagnosis cannot be confirmed on the basis of symptoms alone, because both allergic and non-allergic conditions can present with similar symptoms. Hence, allergy testing in the form of specific IgE (sIgE) measurement is an important aid in demonstrating both the presence and severity of such an allergy. The present study was undertaken to find out the common environmental allergens prevailing in Raichur causing allergic rhinitis, using carbohydrate cross reactive determinants (CCD), an in vitro test with high degree of sensitivity.Methods: The present prospective study was conducted among 30 patients with allergic rhinitis. A detailed general and ENT examination were done, X-ray of PNS, CT scan of PNS, diagnostic nasal endoscopy and nasal smear examination for eosinophils, absolute eosinophil count and serum IgE levels using Euroimmun system of in vitro assay of specific IgE antibodies. Results: Allergy to dust mite, D. faranie, corn, carnation flower, sunflower, sheep wool and straw dust were the most frequent allergens causing allergic symptoms among patients in Raichur area. Total serum IgE was elevated in all the patients, 60% were allergic to dust mite as found by anti CCD specific IgE. Conclusions: Antibodies to dust mite D. faranie, rye, T. mothy grass was the commonest finding. Identification of inhalant allergens is an important factor in prevention and treatment of allergic rhinitis.

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Section: Discussionsupporting

confidence: 61%

A clinical study of inhalant allergens in patients with allergic rhinitis

Choudhari

Sangavi

2017

Int J Otorhinolaryngol Head Neck Surg

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“…The variant near the HLA-DQB1 was regarded as a predictor of total serum IgE levels in multiple race-ethnic groups, which was identified by an independently meta-analysis [31]. The serum total IgE level was used to diagnosis of AR in the in vitro, and high total IgE level suggests that in vitro testing would confirm specific sensitizations in AR patients [32]. The serum total IgE might play a role as a mediator in the development of allergic diseases.…”

Section: Discussionmentioning

confidence: 99%

Replication study of susceptibility variants associated with allergic rhinitis and allergy in Han Chinese

Gao

Zhang

et al. 2020

Allergy Asthma Clin Immunol

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Background: Allergic rhinitis (AR) is believed to be a complex genetic disease. The last decade has been marked by the publication of more than 20 genome-wide association studies (GWASs) of AR and associated allergic phenotypes and allergic diseases, which have shown allergic diseases and traits to share a large number of genetic susceptibility loci. The aim of present study was therefore to investigate the highly replicated allergy related genes and variants as candidates for AR in Han Chinese subjects. Methods: A total of 762 AR patients and 760 control subjects were recruited, and a total of 58 susceptible variants previously reported to be associated with allergic traits were choose for replication. Results: Logistic regression analyses revealed that in the co-dominant-effect model as assessed by the AIC, compared with wild-type carriers, significant AR risk were associated with rs9865818 in LPP (P = 0.029, OR = 1.469 for GG vs. AA); rs6554809 in DNAH5 (P = 0.000, OR = 1.597 for TC vs. CC); rs1438673 in WDR36-CAMK4 loci (P = 0.037, OR = 1.396 for CC vs.TT), rs7775228 in HLA region (P = 0.000, OR = 1.589 for TC vs.TT), rs7203459 in CLEC16A (P = 0.025, OR = 0.731 for TC vs. TT). Conclusion: We replicated Han Chinese AR-specific susceptibility loci in LPP, DNAH5, HLA, CLEC16A and WDR36-CAMK4. Further understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease.

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“…Meanwhile, using only 1 method may misdiagnose every fourth allergically sensitized patient as nonsensitized. Chung et al 27 report that serum total IgE level is useful in the in vitro diagnosis of AR and its high levels may confirm specific sensitizations, but in vitro testing for specific IgE may be unnecessary in patients with low serum total IgE.…”

Section: Discussionmentioning

confidence: 99%

Identification and Prevalence of Allergic, Nonallergic, and Local Allergic Rhinitis Patients in Western Area, Saudi Arabia

Badran

Hussein

Salah

et al. 2016

Ann Otol Rhinol Laryngol

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Objectives: To evaluate the diagnostic yield of skin prick test (SPT) and serum total immunoglobulin E (IgE) antibodies level in patients with allergic rhinitis (AR) and the role of nasal provocation test (NPT) for the determination of local allergic rhinitis (LAR) in patients with nonallergic rhinitis (NAR). Methodology: This multi-center study included 1230 patients with clinical manifestations for ≥2 years. Patients were classified according to the Allergic Rhinitis and Its Impact on Asthma (ARIA) and scored according to the quantitative Score for Allergic Rhinitis (SFAR). The SPT and total IgE antibody levels were done for all patients. Patients gave negative SPT underwent NPT, and its result was interpreted using Lebel Symptom Score Scale. Results: The SPT was positive in 77.8% of patients, mostly for grass pollen and dust mites. All patients were sensitive to multiple allergens. Median serum IgE antibody level for total study population was 162 IU/ml. Forty-two patients (3.4%) with negative SPT showed a weak response to NPT, while 231 patients (18.7%) with negative SPT had a high response to NPT and were considered to have LAR. Conclusion: The SPT could discriminate between AR and NAR patients. The NPT could identify LAR in 84.6% of patients with rhinitis among those considered as NAR.

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The significance of serum total immunoglobulin E for in vitro diagnosis of allergic rhinitis

Cited by 23 publications

References 21 publications

A clinical study of inhalant allergens in patients with allergic rhinitis

A clinical study of inhalant allergens in patients with allergic rhinitis

Replication study of susceptibility variants associated with allergic rhinitis and allergy in Han Chinese

Identification and Prevalence of Allergic, Nonallergic, and Local Allergic Rhinitis Patients in Western Area, Saudi Arabia

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