The significance of serum uric acid level in humans with acute paraquatpoisoning

Abstract

Hyperuricemia is a strong and independent predictor of all-cause mortality in cardiovascular disease and has been found to play a role in diseases exacerbated by oxidative stress and inflammation. This study aimed to evaluate whether serum uric acid (UA) level is an indicator of outcome in patients with acute paraquat poisoning. A total of 205 subjects who had attempted suicide by oral ingestion of paraquat were admitted to the emergency room between January 2009 and June 2014. Initial serum UA level and other laboratory parameters were measured. A total of 66 patients died during the 30 days after admission, corresponding to a 32.2% cumulative incidence of mortality. UA levels were higher in non-survivors than survivors (P < 0.001) and 30-day mortality increased with increasing baseline serum UA level (P < 0.001). In a prediction analysis for 30-day mortality, the serum UA level had a cut-off concentration of 284 µmol/L in female patients and 352 µmol/L in male patients. Multivariate Cox proportional hazards regression analyses showed that white blood cell counts and UA were independent prognostic factors. In conclusion, we showed that serum UA may be an independent predictor of 30-day mortality in patients with paraquat poisoning.

Postoperative neutrophil-to-lymphocyte ratio plus platelet-to-lymphocyte ratio predicts the outcomes of hepatocellular carcinoma

“…Independent risk factors for RFS and OS were identified by stepwise forward Cox regression model [13]. Potential risk factors with a P value of <0.05 in the univariate analysis were included in the multivariate analysis [14]. RFS and OS were determined using the KaplaneMeier method, with comparisons using the logrank test.…”

Prognostic value of hematological parameters in patients with paraquat poisoning

“…We found NLR, leukocyte and neutrophil counts may also be excellent prognostic predictors for acute PQ poisoning. Thirdly, several potential prognostic predictors recently have been indicated have prognostic value in acute PQ poisoning, including serum uric acid28, serum amylase activity29, plasma PTX330, arterial lactate level and lactate metabolic clearance rate7, arterial blood gas analysis31, and so on. In contrast to those potential prognostic predictors, our present stduy have several advantages: 1) our results indicated NLR, leukocyte and neutrophil counts, may be have even better sensitivity and specificity by ROC analysis; 2) the complete blood count is a routine detection in hematological parameters, when patients presenting with acute poisoning to the emergency department; 3) it is important to note that the test results of complete blood count are usually quick, inexpensive and realized in almost all hospital, including local hospitals.…”

Abnormal pancreatic enzymes and their prognostic role after acute paraquat poisoning

“…Single lab analyses, such as serum paraquat concentration 1 7 8 9 , arterial lactate 10 , uric acid 11 , lymphocyte and neutrophil count, and creatinine 12 have been used in risk stratification, and serum paraquat concentration has been thought as the most reliable parameter for prognosis prediction 9 . But it is difficult to extend the serum paraquat concentration technology to district hospitals because the high cost of the assay.…”