The significance of short-term preoperative calcium and activated vitamin D3 supplementation in thyroidectomy: a randomized trial and prospective study

Abstract

Objective The aim was to explore the effects of preoperative calcium and activated vitamin D3 supplementation on post-thyroidectomy hypocalcemia and hypo-parathyroid hormone-emia (hypo-PTHemia). Methods A total of 209 patients were randomly divided into control group (CG) and experimental group (EG). Oral calcium and activated vitamin D3 supplementation were preoperatively administered to EG, whereas a placebo was administered to CG. Data on serum calcium, phosphorus, and PTH concentrations before operation, on postoperative day 1 (POPD1), at postoperative week 3 (POPW3), and on the length of postoperative hospitalization were collected. Results The serum calcium, phosphorus, and PTH concentrations, as well as the incidence of postoperative hypocalcemia and hypo-PTHemia, did not significantly differ between EG and CG. Subgroup analysis revealed that the serum calcium concentrations of the experimental bilateral thyroidectomy subgroup (eBTS) on POPD1 and POPW3 were higher than that of the control bilateral thyroidectomy subgroup (cBTS) (P < 0.05); the reduction of serum calcium in eBTS on POPD1 and POPW3 was less than those in cBTS (P < 0.05). However, significant differences were not observed between the unilateral thyroidectomy subgroups (UTS) (P > 0.05). Moreover, the incidence of postoperative hypocalcemia in cBTS on POPD1 was significantly higher than that in eBTS (65.9% vs 41.7%) (P < 0.05). The length of hospitalization in cBTS (3.55 ± 1.89 days) was significantly longer than that (2.79 ± 1.15 days) in eBTS (P < 0.05). Conclusion Short-term preoperative prophylactic oral calcium and activated vitamin D3 supplementation could effectively reduce the incidence of postoperative hypocalcemia and decrease the length of postoperative hospitalization in patients who have undergone bilateral thyroidectomy.

Hyperspectral and Microtomographic Analyses to Evaluate the Stability of Quercetin and Calcium Effervescent Tablets Exposed to Heat and Ultraviolet Radiation

“…Additionally, calcium plays an important role in smooth muscle contraction, neuronal signaling, activity of intracellular enzyme regulation, blood coagulation, exocytosis, and metabolic regulation [17]. Calcium preparations are indicated as dietary supplements in states of increased calcium requirement, e.g., children who are at risk of rickets during rapid growth, older adults who are at risk of bone fractures, thyroidectomy, postmenopausal women, pre-eclampsia prevention, prediabetes, and sarcopenic, non-malnourished older adults [18][19][20][21][22][23][24]. Increasing the calcium intake of people younger than 35 years of age has been shown to improve bone mineral density throughout the body [25].…”