The Significance of Soy Protein and Soy Bioactive Compounds in the Prophylaxis and Treatment of Osteoporosis

Bawa, S.

doi:10.4061/2010/891058

Cited by 30 publications

(22 citation statements)

References 53 publications

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“…It is well known that nutrition status, including serum albumin, dietary protein, and Vitamin D, is a predictor of bone mineral density (Bawa 2010;Gutiérrez et al 2010;Jeong et al 2010;Jesudason and Clifton 2010). Our data are in agreement with these previous reports (Jeong et al 2010;Jesudason and Clifton 2010).…”

Section: ± 23mentioning

confidence: 99%

“…It is well known that nutritional status, including serum albumin, dietary protein, and Vitamin D, is a related predictor of bone mineral density (Bawa 2010;Gutiérrez et al 2010;Jeong et al 2010;Jesudason and Clifton 2010). Therefore, we hypothesized that arterial stiffness as well as nutritional status may reflect bone mineral density in hypertensive patients.…”

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confidence: 99%

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Association between Bone Mineral Density and Arterial Stiffness in Hypertensive Patients

Masugata

Senda

Inukai

et al. 2011

Tohoku J. Exp. Med.

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Hypertension and osteoporosis are two common diseases in the elderly population. Recently, reduced bone mineral density has been found in hypertensive patients compared with healthy controls. Reduced bone mineral density is associated with increased arterial stiffness in chronic dialysis patients and healthy postmenopausal women. However, relationships between bone mineral density and arterial stiffness in hypertensive patients have not been fully assessed. We examined the relationships between bone mineral density and both arterial stiffness and nutritional status in 52 hypertensive patients (27 male and 25 female subjects; mean age 71 ± 8 years) who had been treated with antihypertensive drugs for at least one year. The bone mineral density of the calcaneus was measured with a quantitative ultrasound measurement device, and the stiffness index was determined as a parameter of the bone mineral density. We measured the cardio-ankle vascular index (CAVI) to assess arterial stiffness and used the serum albumin to assess nutritional status. Increased arterial stiffness as assessed with CAVI is associated with reduced bone mineral density (r = −0.289, p = 0.038). However, the correlation between CAVI and bone mineral density is not as strong as the correlation between serum albumin and bone mineral density (r = 0.501, p < 0.001).In conclusion, nutritional status is an important indicator of bone mineral density in hypertensive patients. Moreover, increased arterial stiffness is associated with reduced bone mineral density in hypertensive patients. Therefore, hypertensive patients with increased arterial stiffness may have a high risk of bone fracture due to osteoporosis.

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Section: ± 23mentioning

confidence: 99%

mentioning

confidence: 99%

Association between Bone Mineral Density and Arterial Stiffness in Hypertensive Patients

Masugata

Senda

Inukai

et al. 2011

Tohoku J. Exp. Med.

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“…There is sufficient evidence suggesting soy isoflavones may have potential benefits for bone, but a relationship has not been established between the consumption of ipriflavone and maintenance of bone mineral density [25].…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Bone Mineral Density and Dietary Intake in Moroccan Children with Juvenile Idiopathic Arthritis

Hassani¹,

Rostom²,

Badri³

et al. 2012

IJCM

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Background and Objective: The aim of this study was to evaluate the association between dietary intake and bone mineral density in children with juvenile idiopathic arthritis (JIA). Methods: A cross-sectional study carried out in Morocco between May 2010 and June 2011, covering out patients with JIA. The characteristics of patients were collected. The nutritional status was assessed by a food questionnaire including data of food intake during 7 consecutive days using 24-hour dietary recall. Food intake was quantified using the software Bilnut (Bilnut version 2.01, 1991). Bone mineral density (BMD in g/cm 2 ) was measured by DXA method (X-ray absorptiometry) on a Lunar Prodigy. Results: The study consisted of 33 patients with JIA (4 -16 years old). The median age of patients was 10.4 ± 4.3 years. Median disease duration was 2 (1 -4.5) years. The group of patients with low dietary intake of proteins was associated with low BMD (p = 0.03). Low BMD was related with low intake of magnesium (p = 0.007) and vitamin C (p = 0.04) in children aged between 4 and 9 years. Low intake of vitamin E and folate was associated with high BMD in the other range of children (p < 0.001). Conclusion: This study suggests that low intake of protein and of some micronutrients (magnesium, vitamin C, vitamin E and folate) influence bone mass in children with JIA. Prospective studies with a larger number of patients seem to be necessary in order to confirm our findings.

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“…These phytoestrogens (e.g., genistein, daidzein, and ipriflavone) may harbor a potential bone-protective effect. Observational studies show higher soy intake in Asian compared with Western diets [89], and lower rates of hip fracture in Asian women compared with Caucasians [90].…”

Section: Isoflavonoidsmentioning

confidence: 99%

Nutrition, Bone, and Aging: An Integrative Physiology Approach

Schulman

Weiss

Mechanick

2011

Curr Osteoporos Rep

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Osteoporosis, a condition associated with significant morbidity and mortality, is prevalent in the growing elderly population. Aging is associated with characteristic changes in the complex pathways of bone remodeling and in patterns of food intake. Whereas the traditional focus of nutritional supplementation for protection of bone health has centered around calcium and vitamin D, a multitude of nutrients have been identified with effects on bone, both individually and in combination. An integrative physiology approach can assist in formulating a deeper understanding of the complex interactions of nutrition and aging with bone, with the goal of identifying modifiable risk factors for the prevention of bone loss.

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The Significance of Soy Protein and Soy Bioactive Compounds in the Prophylaxis and Treatment of Osteoporosis

Cited by 30 publications

References 53 publications

Association between Bone Mineral Density and Arterial Stiffness in Hypertensive Patients

Association between Bone Mineral Density and Arterial Stiffness in Hypertensive Patients

The Relationship between Bone Mineral Density and Dietary Intake in Moroccan Children with Juvenile Idiopathic Arthritis

Nutrition, Bone, and Aging: An Integrative Physiology Approach

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