The significance of systematic lymph node dissection in surgery for early-stage non-small cell lung cancer patients aged ≤40 years

Z, Guo; Ren, Jianghao; Xu, Yuanyuan; Liu, Ruijun; Tao, Hui; Huang, Jia; Tan, Qiang

doi:10.21037/jtd-21-190

Cited by 1 publication

(1 citation statement)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Preoperative evaluation of mediastinal lymph nodes (LNs) in patients with lung cancer is essential for determining optimal treatment strategies in the management of primary lung cancer. On the one hand, the status of mediastinal LNs metastasis can not only affects the formulation of perioperative diagnosis and treatment strategies (1)(2)(3), but also affects the survival time of patients after surgery (4)(5)(6). Therefore, the current National Comprehensive Cancer Network guidelines for non-small cell lung cancer (NSCLC) suggests that N1 (ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary nodes) and N2 (ipsilateral mediastinal and/or subcarinal lymph node(s)) node resection and mapping should be a routine component of lung cancer resections with a minimum of three N2 stations sampled or complete lymph node dissection (7).…”

Section: Introductionmentioning

confidence: 99%

Resection of calcified lymph nodes confers clinical benefit in patients with non‑small cell lung cancer

Wang

Zhang

et al. 2021

Mol Clin Oncol

View full text Add to dashboard Cite

The aim of the present study was to compare the metastatic ratio between calcified lymph node stations (CLNS) and non-CLNS (NCLNS) and to explore the impact of CLNS on surgical outcomes. Consecutive patients with non-small cell lung cancer (NSCLC) scheduled to receive surgical treatment between June and December 2020 were included in the present study. Their clinical and radiological data were prospectively collected and analyzed. A total of 91 patients with NCLNS and 64 patients with CLNS were enrolled in the present study. Out of the 91 patients, 38 (24.516%) patients had 61/343 (17.784%) lymph node stations (LNS) that were metastasized. On a per-patient basis, the differences in the LNS metastatic ratio were not significant between the CLNS with NCLNS groups. However, on a per-nodal station basis, all differences in the LNS metastatic ratio between the groups were significant not only in the all-LNS group (P=0.004), but also in the LNS group which in patients with solely CLNS or NCLNS (P= 0.009) and in the patients with CLNS (P= 0.010). Pathology, T stage and calcification were independent predictive factors for LNS metastasis (P= 0.002, P= 0.021 and P= 0.044, respectively). More patients with CLNS than patients with NCLNS received thoracotomy or conversion from video-assisted thoracoscopic surgery to thoracotomy (P= 0.006). The operating time and blood loss were significantly higher in patients with CLNS than in those without (P<0.001 and P<0.001, respectively). Although CLNS are a risk reduction factor for metastasis and their dissection is time-and blood-consuming in patients with NSCLC, their thorough removal is advisable, since metastases were identified in ~15% of patients and 9% of CLNS.

show abstract