The Significance of the Absence of ¹³¹I-Hippuran Uptake by a Kidney Graft

Abstract

Anuria is a frequent complication during the immediate post-transplantation period in kidney transplant recipients. Radioisotopic studies with ^13lI-Hippuran and ^99mTc-pertechnetate allow correct differentiation between viable and non-viable grafts.

Short Term Prognostic Utility of Tc-99m DMSA Renal Imaging in Sepsis Induced Acute Renal Failure; Provisional Data

“…Bernheim et al in 1976 proposed renal scintigraphic scanning as a tool to assess the prognosis of ARF using hippuran and concluded that its uptake was a parameter which authorized the prognosis of a favorable course whereas its absence permitted one to envisage an unfavorable course [7]. However, in a case report published in 1986; a 35-year-old patient developed ARF on top of acute tubular necrosis requiring hemodialysis and they stated that failure to visualize acutely injured kidneys with Tc-99m DMSA did not preclude recoverable function [4], while the reverse was elicited in another two studies using hippuran [8,9]. Besides, much research is still needed because our understanding of what happens to the kidney in ARF is still poor [10].…”