The significance of the accessory spleen

Molecular Basis of Familial and Acquired Phagocytosis Deficiency Involving the Tetrapeptide, Thr-Lys-Pro-Arg, Tuftsin

“…By contrast, 6 cases with elective sple nectomy yielded much lower values, 94.7 ± 22.5 ng/ml. However, those whose spleen was removed following traumatic rupture and who would most likely develop accessory splenic tissue [2] showed values close to normal 239.0 ±47.7 ng/ml. 1 patient, a girl who had chronic idiopathic thrombocytopenic purpura with recurrent bacterial infections, showed low serum tuftsin levels on three different occasions [15].…”

“…This occurs frequently in splenectomized dogs [27], It was also particularly brought out in cases where splenectomy was performed after accidental rupture of the spleen. Spillage of splenic tissue and implantation in the omentum under these circumstances is well documented [2]. Consequently, normal levels of tuftsin activity in such cases are to be expected and indeed occur [8,15,27], Defective PMN Cell Response On theoretical grounds, one could expect to find defective phagocytic activity in the face of a normal spleen and normal levels of leukokinin and its active tetrapeptide tuftsin.…”

“…The majority of patients that were subjected to elective splenectomy, as a mode of therapy or for staging purposes, showed total absence of tuftsin activity in their sera. It is quite possible that the very few who did not, may well have had accessory spleens or had grown some after the operation [2]. This occurs frequently in splenectomized dogs [27], It was also particularly brought out in cases where splenectomy was performed after accidental rupture of the spleen.…”

Morphological structure of accessory spleen in Chinese hamsters

“…There have been many reports on the incidence and histology of the accessory spleen (AS) in humans [1][2][3][4], rabbits [5,6], chickens [7], mice [8], apes [9] and pigs [10], but these are rarely found in the Chinese hamster. Although Isegawa et al [11] have observed AS in the golden hamster(APA), the morphological structures were not described.…”

A Male Fetus with Aqueductal Stenosis and Four Accessory Spleens

“…In our case, the fetus presented four accessory spleens. Only a few studies have been performed to assess the exact inci dence of accessory spleens in humans [10][11][12], A unique accessory spleen is a quite frequent finding (6.5-15.6%) in these series [10][11][12], In contrast, the incidence of more than three accessory spleens is very low (0.4-1.3%) and is more frequent in cases of associated malformations [10], of hemopathy [11] or after splenectomy [12], These results suggest that the presence of more than three acces sory spleens could be a marker for developmental defect. It is thus necessary to study the relationship between polyspleny and hydrocephalus in a large series of patients with FH after specifying strict criteria to confirm that such an association is not coincidental.…”