The significance of the neutrophil to lymphocyte ratio in silicosis

Oțelea, Marina Ruxandra; Andrei, Nicoleta; Moise, Laura-Georgiana

doi:10.18683/jccp.2018.1036

Cited by 6 publications

(6 citation statements)

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“…Recently, some routine hematological and biochemical tests have shown significant alterations in new combined blood cell count indices of inflammation in idiopathic pulmonary fibrosis (IPF) 26 and connective tissue diseases with pulmonary involvement 27 . Specifically, several works with NLR and PLR have been reported in silicosis disease 28 – 30 , showing that these routine indices and parameters could detect a chronic inflammatory status and help identify patients who may evolve to more severe forms of these diseases; however, no reports have been published in ES silicosis patients, and even less is known about these parameters after prolonged exposure cessation.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory indices obtained from routine blood tests show an inflammatory state associated with disease progression in engineered stone silicosis patients

García-Núñez

Jiménez-Gómez

Hidalgo-Molina

et al. 2022

Sci Rep

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Patients with silicosis caused by occupational exposure to engineered stone (ES) present a rapid progression from simple silicosis (SS) to progressive massive fibrosis (PMF). Patient classification follows international rules based on radiology and high-resolution computed tomography (HRCT), but limited studies, if any, have explored biomarkers from routine clinical tests that can be used as predictors of disease status. Our objective was thus to investigate circulating biomarker levels and systemic inflammatory indices in ES silicosis patients whose exposure to ES dust ended several years ago. Ninety-one adult men, ex-workers in the manufacturing of ES, 53 diagnosed with SS and 38 with PMF, and 22 healthy male volunteers (HC) as controls not exposed to ES dust, were recruited. The following circulating levels of biomarkers like lactate dehydrogenase (LDH), angiotensin-converting-enzyme (ACE), protein C reactive (PCR), rheumatoid factor, alkaline phosphatase and fibrinogen were obtained from clinical reports after being measured from blood samples. As biochemical markers, only LDH (HC = 262 ± 48.1; SS = 315.4 ± 65.4; PMF = 337.6 ± 79.3 U/L), ACE (HC = 43.1 ± 18.4; SS = 78.2 ± 27.2; PMF = 86.1 ± 23.7 U/L) and fibrinogen (HC = 182.3 ± 49.1; SS = 212.2 ± 43.5; PMF = 256 ± 77.3 U/L) levels showed a significant sequential increase, not been observed for the rest of biomarkers, in the HC → SS → PMF direction. Moreover, several systemic inflammation indices neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), systemic inflammation response index (SIRI), systemic immune-inflammation index (SII), aggregate index of systemic inflammation (AISI) derived from whole blood cell counts showed significant differences between the HC, SS and PMF groups. All these biomarkers were analyzed using receiver operating characteristic (ROC) curves, and the results provided moderately high sensitivity and specificity for discriminating between ES silicosis patient groups and healthy controls. Our study reveals that some inflammatory biomarkers, easily available from routine blood analysis, are present in ES silicosis patients even several years after cessation of exposure to ES silica dust and they could help to know the progression of the disease.

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Section: Introductionmentioning

confidence: 99%

Inflammatory indices obtained from routine blood tests show an inflammatory state associated with disease progression in engineered stone silicosis patients

García-Núñez

Jiménez-Gómez

Hidalgo-Molina

et al. 2022

Sci Rep

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“…The evaluation of hematological markers in the present study showed lower lymphocyte counts in individuals with silicosis than in unexposed and exposed individuals without silicosis, with no differences in neutrophil or platelet counts, similar to a recently published study. 35 Furthermore, increased NLRs and PLRs have been observed in previous studies, [1][2][3]35 in which individuals with silicosis and elevated NLRs and PLRs had poorer prognoses. These markers are also important for differentiating between individuals not exposed to silica and those with silicosis and are altered even years after cessation of exposure to silica.…”

Section: Biomarkers Associated With Silicosismentioning

confidence: 83%

“…Previous studies have demonstrated the relationship between higher levels of inflammatory markers and increased risk of silicosis, greater radiological severity, and decreased pulmonary function in individuals exposed to silica, [1][2][3][4][5][29][30][31][32] however, the results are still controversial due to the heterogeneity of the studied populations and markers and the study designs. This theme is relevant in the context of a potentially severe disease, where the use of markers could help monitor workers exposed to silica, enabling early diagnosis.…”

Section: Biomarkers Associated With Silicosismentioning

confidence: 99%

“…Multiple biomarkers of exposure, effect, and susceptibility have been studied in recent years with the goal of identifying the pathological processes that precede the onset of silicosis or for tracking its progression, as well as for predicting greater risk of developing silicosis in exposed individuals, a sharp decline in lung function or exercise performance, and greater changes on imaging examinations 1–5 . However, the use of biomarkers in clinical practice is not yet well established.…”

Section: Introductionmentioning

confidence: 99%

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Biomarkers related to silicosis and pulmonary function in individuals exposed to silica

Lombardi,

Mizutani,

Terra‐Filho

et al. 2023

American J Industrial Med

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BackgroundThe identification of markers that can facilitate the early diagnosis of silicosis has remained challenging. We evaluated the association of inflammatory markers with the presence of silicosis and lung function impairment in individuals exposed to silica.MethodsIndividuals exposed and not exposed to silica were assessed by occupational history, clinical findings, lung function, chest imaging findings, and inflammatory markers.ResultsAmong 297 men evaluated, 51 were unexposed controls (G1), 149 were exposed to silica without silicosis (G2), and 97 were exposed to silica with silicosis (G3). Inflammatory marker levels were higher in G3 than in G2 and G1. Platelet/lymphocyte ratio (PLR), lactate dehydrogenase (LDH), soluble tumor necrosis factor II (sTNFRII), and macrophage inflammatory protein‐4 (MIP‐4) were associated with silicosis, and LDH, neutrophil/lymphocyte ratio (NLR), sTNFRII, monocyte chemoattractant protein‐1 (MCP‐1), soluble vascular cell adhesion molecule‐1 (sVCAM‐1), and fibrinogen were negatively associated with lung function.ConclusionBlood inflammatory markers are associated with silicosis and impaired lung function.

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“…In silicosis, we have reported that NLR is [28] a predictor for silicosis evolution, when the major possible confounders were excluded (smoking and any chronic or acute lung disease). In this study, we had excluded only the acute lung disease, due to the limited number of patients.…”

Section: Resultsmentioning

confidence: 99%

Inflammation Markers in the Evolution of Asbestosis

Oțelea¹,

Andrei²,

Dinu³

et al. 2019

Rev. Chim.

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Asbestos structure and composition contribute to the lung injury and to the inflammation induced by this natural fiber. The result of this study is that neutrophile to lymphocyte ratio correlates significantly to timing of progress of the radiological lesions in the evolution of patients with asbestosis, followed for 5 years. If confirmed in larger studies, this could become a cost-effective biomarker for the asbestosis evolution.

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The significance of the neutrophil to lymphocyte ratio in silicosis

Cited by 6 publications

References 0 publications

Inflammatory indices obtained from routine blood tests show an inflammatory state associated with disease progression in engineered stone silicosis patients

Inflammatory indices obtained from routine blood tests show an inflammatory state associated with disease progression in engineered stone silicosis patients

Biomarkers related to silicosis and pulmonary function in individuals exposed to silica

Inflammation Markers in the Evolution of Asbestosis

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