The significance of the rabbit's septum as a relay station between the midbrain and the hippocampus I. The control of hippocampus arousal activity by the septum cells

Petsche, H.; Stumpf, Ch.; Gogolák, G.

doi:10.1016/0013-4694(62)90030-5

Cited by 683 publications

(268 citation statements)

References 28 publications

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“…Bispectral and bicoherence analyses of these simultaneously expressed oscillations showed strong coupling in the theta-gamma wave bands. The field recordings still lacked the overt, large amplitude theta waves seen in vivo (see above), but this conclusion was not surprising given the absence of medial septum-diagonal band of Broca input (35). However, the phase locking of spatially distributed regions of hippocampus can occur in the absence of this input.…”

Section: Discussionmentioning

confidence: 90%

Orthogonal arrangement of rhythm-generating microcircuits in the hippocampus

Gloveli

Dugladze

Rotstein

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

224

212

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As a structure involved in learning and memory, the hippocampus functions as a network. The functional differentiation along the longitudinal axis of the hippocampus is poorly demarcated in comparison with the transverse axis. Using patch clamp recordings in conjunction with post hoc anatomy, we have examined the pattern of connectivity and the functional differentiation along the long axis of the hippocampus. Here, we provide anatomical and physiological evidence that the prominent rhythmic network activities of the hippocampus, the behavior-specific gamma and theta oscillations, are seen predominantly along the transverse and longitudinal axes respectively. This orthogonal relationship is the result of the axonal field trajectories and the consequential interaction of the principal cells and major interneuron subtypes involved in generating each rhythm. Thus, the axonal arborization patterns of hippocampal inhibitory cells may represent a structural framework for the spatiotemporal distribution of activity observed within the hippocampus.interneurons ͉ oscillations ͉ patch clamp T he hippocampus is required for the encoding of new information and for retrieving information shortly after acquisition (1). Spatial information is coded at theta frequencies (2) by clusters of neurons segmentally distributed along the longitudinal axis of the hippocampus (3). Gamma oscillations are also generated by the hippocampus nested within these theta rhythms and are thought to be involved in transient neuronal assembly formation (4), information transmission, and storage (5).As previous observation has shown, the hippocampus is made up of multiple lamellae organized in parallel across the long axis, in which each lamella contains a functionally independent transverse circuit (6). The well defined connections between subregions along the transverse axis facilitates the investigation of crucial neurobiological processes such as network oscillatory activity in the in vitro preparation. Although the functionally segregated subregions of the long axis of the hippocampal formation may cooperate with each other during memory formation (for review, see ref. 7), morphological evidence about their interconnectivity is sparse. Although CA3 neurons connect to other CA3 neurons (8, 9), and excitation of interneurons occurs along the longitudinal axis (10), the involvement of hippocampal interneurons in the functional circuit along the longitudinal axis of hippocampus is still unclear.Interneurons serve a wide variety of functions in the brain, amongst them generating and maintaining local or large scale coherent activity (for review, see ref. 11). They also have a particularly pivotal role in driving inhibition-based rhythms, such as gamma and theta frequency network oscillations (12-16). Theta rhythms are seen as a major operational mode of the hippocampus (for review, see ref. 17), and clusters of neurons that encode information required to perform spatial and nonspatial short-term memory tasks during theta rhythms are distributed in di...

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Section: Discussionmentioning

confidence: 90%

Orthogonal arrangement of rhythm-generating microcircuits in the hippocampus

Gloveli

Dugladze

Rotstein

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

224

212

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“…Hippocampal activity could entrain other pacemakers such as cholinergic populations in the basal forebrain (Petsche et al, 1962;Tó th et al, 1993; M. G. or the supramammillary nucleus (Kocsis and Vertes, 1994). Alternatively, the hippocampus (subfield CA1) could synchronize with monosynaptic targets in the entorhinal cortex (Colgin and Moser, 2006) and indirectly use their widespread connectivity.…”

Section: Discussionmentioning

confidence: 99%

Hippocampal Theta-Phase Modulation of Replay Correlates with Configural-Relational Short-Term Memory Performance: Figure 1.

Poch¹,

Fuentemilla²,

Barnes³

et al. 2011

J. Neurosci.

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There is now growing evidence that the hippocampus generates theta rhythms that can phase bias fast neural oscillations in the neocortex, allowing coordination of widespread fast oscillatory populations outside limbic areas. A recent magnetoencephalographic study showed that maintenance of configural-relational scene information in a delayed match-to-sample (DMS) task was associated with replay of that information during the delay period. The periodicity of the replay was coordinated by the phase of the ongoing theta rhythm, and the degree of theta coordination during the delay period was positively correlated with DMS performance. Here, we reanalyzed these data to investigate which brain regions were involved in generating the theta oscillations that coordinated the periodic replay of configuralrelational information. We used a beamformer algorithm to produce estimates of regional theta rhythms and constructed volumetric images of the phase-locking between the local theta cycle and the instances of replay (in the 13-80 Hz band). We found that individual differences in DMS performance for configural-relational associations were related to the degree of phase coupling of instances of cortical reactivations to theta oscillations generated in the right posterior hippocampus and the right inferior frontal gyrus. This demonstrates that the timing of memory reactivations in humans is biased toward hippocampal theta phase.

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“…A crucial structure involved in theta oscillations is the medial septum-diagonal band of Broca (MSDB), because its lesion or disconnection from the hippocampus abolishes theta (Green and Arduni, 1954;Petsche et al, 1962). GABAergic and cholinergic neurons of the MSDB contribute to the theta rhythm by feed-forward disinhibition of CA1 pyramidal cells via the interneurons, and cholinergic activation of an intrahippocampal CA3 theta oscillator (Buzsáki, 2002).…”

Section: Slow (<1 Hz) Rhythms-mirceamentioning

confidence: 99%

Interaction between neocortical and hippocampal networks via slow oscillations

Sirota

Buzsáki

2005

THL

234

219

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Both the thalamocortical and limbic systems generate a variety of brain state-dependent rhythms but the relationship between the oscillatory families is not well understood. Transfer of information across structures can be controlled by the offset oscillations. We suggest that slow oscillation of the neocortex, which was discovered by Mircea Steriade, temporally coordinates the self-organized oscillations in the neocortex, entorhinal cortex, subiculum and hippocampus. Transient coupling between rhythms can guide bidirectional information transfer among these structures and might serve to consolidate memory traces.

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The significance of the rabbit's septum as a relay station between the midbrain and the hippocampus I. The control of hippocampus arousal activity by the septum cells

Cited by 683 publications

References 28 publications

Orthogonal arrangement of rhythm-generating microcircuits in the hippocampus

Orthogonal arrangement of rhythm-generating microcircuits in the hippocampus

Hippocampal Theta-Phase Modulation of Replay Correlates with Configural-Relational Short-Term Memory Performance: Figure 1.

Interaction between neocortical and hippocampal networks via slow oscillations

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