The significant antidyslipidemic, hypoglycemic, antihyperglycemic, and antiobesity activities of the aqueous extracts of Agave Sisalana juice are partly mediated via modulation of calcium signaling pathways

Chege, Boniface Mwangi; Nyaga, Nelly Murugi; Kaur, Prabjot Sehmi; Misigo, Wycliffe Odhiambo; Khan, Nelson; Wanyonyi, Wycliffe Chisutia; Mwangi, Peter Waweru

doi:10.1016/j.heliyon.2022.e12400

Cited by 7 publications

(1 citation statement)

References 26 publications

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“…It also resulted in a decreased activity in glucose-6-phosphatase and fructose 1,6-bisphosphatase, both precursors for forming free glucose in the gluconeogenesis process catalyzed by FBPase [ 65 ]. In another study, the proponents confirmed the hypoglycemic effects of Agave sisalana , but could not identify the specific key ingredient from the observed antidiabetic activity [ 66 ]. No studies have investigated the antihyperglycemic potential of Piper anducum, but the antidiabetic potential of Piper claussenianum , a closely related plant from the same family, was studied.…”

Section: Resultsmentioning

confidence: 99%

In Silico Screening and Identification of Antidiabetic Inhibitors Sourced from Phytochemicals of Philippine Plants against Four Protein Targets of Diabetes (PTP1B, DPP-4, SGLT-2, and FBPase)

Macalalad

Gonzales

2023

Molecules

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Current oral medications for type 2 diabetes target a single main physiological mechanism. They either activate or inhibit receptors to enhance insulin sensitivity, increase insulin secretion, inhibit glucose absorption, or inhibit glucose production. In advanced stages, combination therapy may be required because of the limited efficacy of single-target drugs; however, medications are becoming more costly, and there is also the risk of developing the combined side effects of each drug. Thus, identifying a multi-target drug may be the best strategy to improve treatment efficacy. This study sees the potential of 2657 Filipino phytochemicals as a source of natural inhibitors against four targets of diabetes: PTP1B, DPP-4, SGLT-2, and FBPase. Different computer-aided drug discovery techniques, including ADMET profiling, DFT optimization, molecular docking, MD simulations, and MM/PBSA energy calculations, were employed to elucidate the stability and determine the binding affinity of the candidate ligands. Through in silico methods, we have identified seven potential natural inhibitors against PTP1B, DPP-4, and FBPase, and ten against SGLT-2. Eight plants containing at least one natural inhibitor of each protein target were also identified. It is recommended to further investigate the plants’ potential to be transformed into a safe and scientifically validated multi-target drug for diabetes therapies.

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Section: Resultsmentioning

confidence: 99%