The significant prognostic value of circulating tumor cells in triple-negative breast cancer: a meta-analysis

Lu, Yanjun; Wang, Peng; Wang, Xiong; Peng, Jing; Zhu, Yaowu; Shen, Na

doi:10.18632/oncotarget.8156

Cited by 31 publications

(27 citation statements)

References 41 publications

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“…Circulating tumor cells (CTCs), defined as tumor cells that have originated from a primary tumor and circulate into the blood in cancer patients, are one of the promising biomarkers in liquid biopsy, a non‐invasive method for assessing tumor progression in real time . The clinical usefulness of CTCs in cancer patients has been studied extensively in various malignancies such as breast, lung, colorectal, and gastric cancer . However, the clinical significance of CTCs in patients with ESCC remains unclear.…”

Section: Introductionmentioning

confidence: 99%

“…5 The clinical usefulness of CTCs in cancer patients has been studied extensively in various malignancies such as breast, lung, colorectal, and gastric cancer. [6][7][8][9] However, the clinical significance of CTCs in patients with ESCC remains unclear. Most prior studies were based on small cohorts of subjects, and the results were inconsistent.…”

Section: Introductionmentioning

confidence: 99%

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Circulating tumor cells detected using fluid‐assisted separation technique in esophageal squamous cell carcinoma

Choi

Kim

Hoseok

et al. 2018

J of Gastro and Hepatol

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Background and Aim Esophageal squamous cell carcinoma (ESCC) is one of the aggressive gastrointestinal tract cancers. Detection of circulating tumor cells (CTCs) in peripheral blood from patients with various malignancies has been reported to have diagnostic, prognostic, and therapeutic implications. We aimed to evaluate CTCs in patients with ESCC and assess the clinical significance of CTCs in the early diagnosis of ESCC. Methods Peripheral blood samples for CTCs analyses were prospectively obtained from 73 patients with ESCC prior to treatment between March 2015 and June 2018. CTCs were detected using a centrifugal microfluidic system with a new fluid‐assisted separation technique. Blood samples from 31 healthy volunteers were used as controls. Results After creating a receiver operating characteristic curve to determine the optimal CTC threshold to differentiate patients with ESCC from healthy controls, sensitivity and specificity were most optimized at a CTC threshold of two per 7.5 mL of blood. Among 66 subjects with ≥ 2 CTCs per 7.5 mL of blood, 63 (95.5%) had ESCC. Among 38 subjects with < 2 CTCs per 7.5 mL of blood, 28 (73.7%) were healthy controls. When using this threshold, the sensitivity and specificity for differentiating patients with ESCC from healthy controls were 86.3% and 90.3%, respectively. CTC count was associated with tumor–node–metastasis stage, especially lymph node metastasis, but there was no correlation with any other relevant clinicopathologic variable. Conclusions Our results suggest that CTCs detected using fluid‐assisted separation technique could be helpful for early diagnosis of ESCC. Further large‐scale prospective studies are warranted to validate our findings.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Circulating tumor cells detected using fluid‐assisted separation technique in esophageal squamous cell carcinoma

Choi

Kim

Hoseok

et al. 2018

J of Gastro and Hepatol

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“…In recent years, accumulating evidence has demonstrated the prognostic role of CTCs in the peripheral blood in several human cancers, such as gastric cancer 4 , head and neck squamous cell carcinoma 5 , prostate cancer 6 , and breast cancer 7 , as well as its subtypes 8 . However, these studies primarily focused on metastatic cancers.…”

Section: Introductionmentioning

confidence: 99%

Meta-analysis Reveals the Prognostic Value of Circulating Tumour Cells Detected in the Peripheral Blood in Patients with Non-Metastatic Colorectal Cancer

Wang

Peng

et al. 2017

Sci Rep

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Detecting circulating tumour cells (CTCs) is considered as effective and minimally invasive technique to predict the prognosis of patients with metastatic colorectal cancer (CRC), but its clinical validity is still conflicting in patients without metastasis. We performed this meta-analysis to evaluate whether detection of CTCs in the peripheral blood can be used as a prognostic marker for patients with non-metastatic CRC. We performed a comprehensive search of the EMBASE, PubMed, and Web of Science databases (up to September 2016). Meta-analyses were conducted using a random-effects model with the hazard ratio (HR) and 95% confidence interval (95% CI) as the effect measures. Twenty studies including 3,687 patients were eligible for inclusion. Overall analyses demonstrated that the presence of CTCs was significantly associated with aggressive disease progression (HR = 2.57, 95% CI = 1.64–4.02, P heterogeneity < 0.001, I 2 = 81.0%) and reduced disease survival (HR = 2.41, 95% CI = 1.66–3.51, P heterogeneity = 0.002, I 2 = 59.7%). Subgroup analyses further supported the prognostic effect of CTCs based on different subsets, including sampling time, detection method and cancer type. Our findings suggest that detection of CTCs in the peripheral blood has the clinical utility to indicate poor prognosis in patients with non-metastatic CRC.

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“…As described in the "seed and soil" theory (29), CTCs are regarded as critical factors for tumours metastasis (30). As demonstrated in many studies, high CTCs in peripheral blood was associated with the poor survival in many solid tumours, such as breast cancer (31), bladder cancer(32), ovarian cancer and gastric cancer (33,34). In addition, due to its benefits of time and cost saving, easy operation and higher specificity and reproducibility, CTC detection from PB can be regarded as an effective evaluation tool for monitoring and assessing treatment effects in EC patients.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Circulating Tumour Cells detected with the CellSearch System in Esophageal Cancer Patients: A Systematic Review and Meta-Analysis

Yang

et al. 2020

Preprint

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Background: Esophageal carcinoma (EC) is the seventh-most prevalent tumour in the world, which is still the primary cause of tumour-related death. Identifying noteworthy biomarkers for EC is particularly significant in guiding active and effective treatment. Recently, circulating tumour cells (CTCs) in peripheral blood (PB) were intensively discussed as prognostic markers in patients with EC. However, an ongoing controversy still exists regarding the prognostic significance of CTCs determined using the CellSearch System in EC sufferers. This meta-analysis was designed to approach this topic. Methods: We systematically conducted searches using PubMed, Medline, Web of Science and the Cochrane Library for relevant studies, which were published through February 20, 2020. Using the random-effects model, our study was performed in Review Manager software, with odds ratios (ORs), risk ratios (RRs), hazard ratios (HRs) and 95% confidence intervals (CIs) as effect values. Results: In total, 7 articles were finally included in this study. For clinicopathological characteristics, the pooled results on TNM stage indicated that the III/IV group had higher incidence of CTCs compared with the I/II group (OR=1.36, 95% CI (0.68,2.71), I2=0%). Incidence of CTCs was higher among patients on T3/T4 stage (OR=2.92, 95% CI (1.31,6.51), I2=0%) and distant metastasis group (OR=5.18, 95% CI (2.38,11.25), I2=0%) compared to patients on T1/T2 stage or non-metastatic group. The pooled analysis revealed that CTC positivity detected in EC patients was correlated with poor overall survival (OS) (HR =2.83, 95% CI (1.99,4.03), I2=0%) and relapse-free survival (RFS) (HR =4.71, 95% CI (2.73,8.13), I2=0%). When pooling the estimated RR, a poor therapeutic response to chemoradiotherapy was discovered in patients with CTC positivity (RR =1.99, 95% CI (1.73,2.29), I2=60%). Conclusions: In summary, our meta-analysis demonstrated that CTCs from PB of EC patients determined using the CellSearch System are correlated with the prognosis of EC patients and might indicate a poor therapeutic response to chemotherapy in EC patients.

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The significant prognostic value of circulating tumor cells in triple-negative breast cancer: a meta-analysis

Cited by 31 publications

References 41 publications

Circulating tumor cells detected using fluid‐assisted separation technique in esophageal squamous cell carcinoma

Circulating tumor cells detected using fluid‐assisted separation technique in esophageal squamous cell carcinoma

Meta-analysis Reveals the Prognostic Value of Circulating Tumour Cells Detected in the Peripheral Blood in Patients with Non-Metastatic Colorectal Cancer

Prognostic Value of Circulating Tumour Cells detected with the CellSearch System in Esophageal Cancer Patients: A Systematic Review and Meta-Analysis

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