The significant role of Carbapenems-resistant Acinetobacter Baumannii in mortality rate of patients with COVID-19

Alimohammadi, Ali; Chazani-Sharahi, Nahid; Hezaveh, Zahra Asgari; Abbasi, Elnaz; Shariati, Aref; Ghaznavi‐Rad, Ehsanollah

doi:10.1016/j.vacun.2022.10.004

Cited by 7 publications

(4 citation statements)

References 22 publications

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“…The results are similar to those of previous studies. 11,[22][23][24][25] Improper empirical antibiotic treatment and the severity of the disease may play a major role. Some scholars found that the exposure of carbapenems increased the risk of VAP resistance of A. baumannii.…”

Section: Discussionmentioning

confidence: 99%

Establishment and Validation of a Risk Prediction Model for Mortality in Patients with Acinetobacter baumannii Infection: A Retrospective Study

Song,

Zhang,

Zhang

et al. 2023

IDR

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Purpose This study aims to establish a valuable risk prediction model for mortality in patients with Acinetobacter baumannii ( A. baumannii ). Patients and Methods The 622 patients with A. baumannii infection from the First Affiliated Hospital of Anhui Medical University were enrolled as the study cohort. Univariate and multivariate logistic regression analysis was used to preliminarily screen the independent risk factors of death caused by A. baumannii infection, followed by LASSO regression analysis to determine the risk factors. According to the calculated regression coefficient, the Nomogram death prediction model is established. The area under the curve (AUC) and decision curve analysis (DCA) of the operating characteristic (ROC) curve of the subjects are used to evaluate the discrimination of the established prediction model. The calibration degree of the prediction model is represented by a calibration chart. A validation cohort that consisted of 477 patients admitted to the 901st Hospital was also included. Results Our results revealed that the source of infection, carbapenem-resistant A. baumannii , mechanical ventilation, serum albumin value, and Charlson comorbidity index were independent risk factors for death caused by A. baumannii infection. The AUC value of ROC curves of study cohort and validation cohort were 0.76 and 0.69, respectively. The probability range (30–80%) indicated a high net income of the modified model and strong capacity of discrimination. The calibration curve obtained by analysis swings up and down around the 45 diagonal line, which shows that the calibration degree of the prediction model is very high. Conclusion In this study, we have reconstructed a risk prediction model for mortality in patients with A. baumannii infections. This model provides useful information to predict the risk of death in patients with A. baumannii infection, but the specificity is not optimistic. If this prediction model is wanted to be applied to clinical practice, more analysis and research are necessary.

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Section: Discussionmentioning

confidence: 99%

Establishment and Validation of a Risk Prediction Model for Mortality in Patients with Acinetobacter baumannii Infection: A Retrospective Study

Song,

Zhang,

Zhang

et al. 2023

IDR

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“…Carbapenem-resistant Acinetobacter baumannii (CRAB) is a challenging nosocomial pathogen in patients admitted to intensive care units (ICUs) and is suggested as one of the most prevalent organisms causing opportunist infections in patients with COVID-19 [5]. An antimicrobial resistance surveillance system in South Korea reported that the carbapenem resistance rate of A. baumannii strains was as high as 89.9%, and mostly associated with bla OXA-23 -like genes.…”

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confidence: 99%

“…Our study focused on patients with CRAB BSI, in contrast to others which included various presentations of CRAB infection including BSI [5, 7]. In line with our results, the latter studies also observed a significant role of CRAB co-infection in the mortality rate of those with COVID-19, compared to other clinical presentations [5, 7]. Indeed, a recent study has also suggested that COVID-19 has a negative prognostic impact on patients with multidrug-resistant-Gram-negative BSI [3].…”

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confidence: 99%

“…Accordingly, several CRAB outbreaks have been reported in these patients worldwide and A. baumannii has been a leading agent of bacterial co-infection in COVID-19 patients [6]. Our study focused on patients with CRAB BSI, in contrast to others which included various presentations of CRAB infection including BSI [5,7]. In line with our results, the latter studies also observed a significant role of CRAB co-infection in the mortality rate of those with COVID-19, compared to other clinical presentations [5,7].…”

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confidence: 99%

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Clinical impact of COVID-19 in patients with carbapenem-resistant Acinetobacter baumannii bacteraemia

Kim,

Lee,

Suh

et al. 2023

Epidemiol. Infect.

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The aim of this study was to evaluate the impact of coronavirus disease 2019 (COVID-19) on treatment outcomes in critically ill patients with carbapenem-resistant Acinetobacter baumannii (CRAB) bloodstream infection (BSI). This single-centre, retrospective cohort study was conducted in a 1,048-bed university-affiliated tertiary hospital in the Republic of Korea from January 2021 to March 2022. The study participants included consecutive hospitalised adult patients (aged ≥18 years) in the intensive care unit with CRAB monomicrobial BSI. During the study period, a total of 70 patients were included in our study, and 24 (34.3%) were diagnosed with COVID-19. The 28-day mortality rate was 64.3%. In the multivariate Cox proportional hazard regression analysis, diagnosis of COVID-19 (hazard ratio (HR), 2.91; 95% confidence interval (CI): 1.45–5.87), neutropenia (HR, 2.76; 95% CI: 1.04–7.29), Pitt bacteraemia score (per point; HR, 1.30; 95% CI: 1.19–1.41), and appropriate definite antibiotic therapy (HR, 0.31; 95% CI: 0.15–0.62) were independent predictors of 28-day mortality in patients with CRAB BSI. In conclusion, our findings suggested that COVID-19 has a negative prognostic impact on patients with CRAB BSI. Further study is needed to investigate the specific mechanisms of how COVID-19 worsens the prognosis of CRAB infection.

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Analysis of the potentially pathogenic bacteria of lower respiratory tract infections in children per-, during and post-COVID-19: a retrospective study

Xu,

Meng,

et al. 2024

Eur J Clin Microbiol Infect Dis

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The significant role of Carbapenems-resistant Acinetobacter Baumannii in mortality rate of patients with COVID-19

Cited by 7 publications

References 22 publications

Establishment and Validation of a Risk Prediction Model for Mortality in Patients with Acinetobacter baumannii Infection: A Retrospective Study

Establishment and Validation of a Risk Prediction Model for Mortality in Patients with Acinetobacter baumannii Infection: A Retrospective Study

Clinical impact of COVID-19 in patients with carbapenem-resistant Acinetobacter baumannii bacteraemia

Analysis of the potentially pathogenic bacteria of lower respiratory tract infections in children per-, during and post-COVID-19: a retrospective study

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