The silent reservoir? SARS-CoV-2 detection in the middle ear effusion of patients with Otitis media with effusion after omicron infection

Han, Chengzhou; Wang, Huifang; Wang, Ying; Hang, Chao; Wang, Yangyang; Meng, Xiangming

doi:10.1016/j.amjoto.2024.104229

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…Second, the Omicron variation of SARS-CoV-2 generates a higher and more sustained viral load in the nasopharynx than the previously predominant Delta version [ 33 ]. Third, SARS-CoV-2 might invade the ME mucosae and the mastoids [ 21 ]. Fourth, the patient experienced nasal congestion and a runny nose during the SARS-CoV-2 infection.…”

Section: Discussionmentioning

confidence: 99%

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Clinical manifestations and outcomes of otitis media with effusion in adult patients following Omicron infection in China

Meng,

Wang,

Han

et al. 2024

Biomol Biomed

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This study investigates the clinical features and therapeutic outcomes of otitis media with effusion (OME) in adults following infection with the Omicron variant of coronavirus disease 2019 (COVID-19), in the context of China ending its "Zero-COVID-19" policy. Conducted as a multicenter, retrospective analysis at two medical institutions in Eastern China from December 2022 to February 2023, the study included patients with confirmed Omicron infection who were diagnosed with OME within two months, adhering to guidelines from the American Academy of Otolaryngology-Head and Neck Surgery Foundation (AAO-HNSF). Data on demographics, time from infection to OME manifestation, associated symptoms, and treatment outcomes were collected. Among 68 patients (73 affected ears) with OME post-Omicron infection, common symptoms included cough and nasal obstruction (69.1%). All reported ear fullness, with 86.8% experiencing hearing loss. Tympanic bullae were observed in 72.6% during otoscopy, and most tympanometry results showed a B-type tympanogram (80.0%). An integrated treatment strategy led to an 83.6% cure rate, although 8.2% experienced relapse within 2-3 months. Our findings highlight OME as a prevalent ear complication associated with COVID-19 during the Omicron pandemic, underscoring the necessity for further investigation into its complexities. While the integrated treatment approach proved effective, the 8.2% post-treatment recurrence rate underscores the importance of ongoing monitoring and signals an urgent need for more comprehensive research.

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Section: Discussionmentioning

confidence: 99%

“…Recent studies have confirmed the presence of SARS-CoV-2 in the ME effusion (MEE) of patients with OME post-COVID-19 infection, highlighting the virus’s critical role in the pathogenesis of OME [ 20 , 21 ]. Additionally, SARS-CoV-2 is known to exhibit a high viral load in the nasopharynx [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical manifestations and outcomes of otitis media with effusion in adult patients following Omicron infection in China

Meng,

Wang,

Han

et al. 2024

Biomol Biomed

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“…Additionally, the COVID-19 pandemic, during the study's final years, added complexity by impacting various otolaryngology conditions, including AE, and disrupting healthcare services, which could have influenced our results. 6,28,[31][32][33][34][35][36][37] Furthermore, aside from recognizing environmental factors like temperature and humidity, there is still insufficient knowledge about the underlying mechanisms driving the diverse incidence patterns of AE throughout the 24 STs.…”

mentioning

confidence: 99%

Rising Incidence of Acute Epiglottitis in Eastern China: An Eight-Year Retrospective Study and Its Association with the 24 Solar Terms

Lu,

Wang,

Miao

et al. 2024

IJGM

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This study aimed to investigate the clinical characteristics of acute epiglottitis (AE) patients in East China and examine the correlation between the incidence of AE and the 24 solar terms (24 STs). Methods: A retrospective, observational study was conducted on patients diagnosed with AE between January 2014 and December 2021 at a single-center medical institution in East China. The clinical characteristics of patients with AE and their correlation with the 24 STs were investigated. Results: A total of 287 patients with AE were included in this study, among which there were 179 males (62.37%) and 108 females (37.63%), with a mean age of 47.79 ± 13.83 years (range 16-87 years). Of these patients, 100 (34.84%) had at least one comorbidity and the most common comorbidities were hypertension, smoking and type 2 diabetes. The duration of hospitalization was 3 days (IQR, 1-16 days). All patients, except for one who required tracheal intubation, were cured with intravenous antibiotic administration and the combined use of corticosteroids. The incidence of AE showed significant fluctuations between the 24 STs and the highest number of cases occurred during the Summer solstice (24 cases, 8.36%). Conclusion:The incidence of AE was seen to increase annually in this study. The main features of AE are sore throat, dysphagia, odynophagia and fever, which may be accompanied by inflammation in surrounding areas. A clear correlation exists between the incidence of AE and the fluctuations within the 24 STs, notably with the peak incidence observed during the Summer solstice, which approximately corresponds to June 21 to July 7 in the Gregorian calendar.

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Incidence of hearing loss following COVID-19 among young adults in South Korea: a nationwide cohort study

Kim,

Jeong,

Kim

et al. 2024

eClinicalMedicine

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The silent reservoir? SARS-CoV-2 detection in the middle ear effusion of patients with Otitis media with effusion after omicron infection

Cited by 4 publications

References 24 publications

Clinical manifestations and outcomes of otitis media with effusion in adult patients following Omicron infection in China

Clinical manifestations and outcomes of otitis media with effusion in adult patients following Omicron infection in China

Rising Incidence of Acute Epiglottitis in Eastern China: An Eight-Year Retrospective Study and Its Association with the 24 Solar Terms

Incidence of hearing loss following COVID-19 among young adults in South Korea: a nationwide cohort study

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